Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 57237651

GI number: 57237651

Start: 837165

End: 838061

Strand: Direct

Name: dapA [H]

Synonym: CJE0897

Alternate gene names: 57237651

Gene position: 837165-838061 (Clockwise)

Preceding gene: 57237650

Following gene: 57237652

Centisome position: 47.09

GC content: 33.89

Gene sequence:

>897_bases
ATGGATAAAAATATTATTATTGGGGCAATGACGGCCCTTATTACACCGTTTAAAAATGGAAAAGTTGATGAGCAAAGTTA
TGCAAGATTGATTAAAAGGCAAATAGAAAATGGCATCGATGCAGTAGTTCCAGTAGGAACAACAGGAGAAAGTGCAACTT
TAACCCATGAAGAACATAGAACTTGCATAGAAATAGCCGTTGAGACTTGTAAAGGAACTAAAGTTAAGGTTTTAGCAGGT
GCGGGAAGTAATGCAACTCATGAGGCAGTGGGTTTGGCTAAATTTGCTAAAGAGCATGGTGCTGATGGGATTTTAAGTGT
GGTACCGTATTATAATAAACCTACGCAACAAGGACTTTACGAGCATTATAAGGCTATTGCGCAAAGTGTAGATATTCCTG
TGCTTTTATATAATGTTCCAGGAAGAACAGGTTGTGAAATTTCAACGGATACTATTATCAAGCTTTTTAGAGATTGTGAA
AATATTTATGGAGTAAAAGAAGCGAGTGGAAATATCGATAAGTGTGTGGATTTGCTTGCACACGAACCTAGAATGATGCT
TATTTCAGGGGAAGATGCGATCAATTATCCTATACTTTCAAATGGTGGAAAGGGAGTGATTTCAGTAACTTCAAATTTAT
TACCCGATATGATTAGCGCTTTAACTCATTTTGCTTTAGATGAAAATTATAAAGAAGCTAAAAAAATCAATGATGAGCTT
TATAATATCAATAAAATTTTATTTTGCGAAAGTAATCCTATTCCTATTAAAACGGCTATGTATTTAGCTGGATTGATAGA
AAGTTTGGAATTTAGACTTCCTCTTTGTTCTCCAAGTAAGGAAAATTTTGCTAAAATTGAAGAAGTGATGAAAAAATATA
AGATCAAAGGATTTTAA

Upstream 100 bases:

>100_bases
AAAGATATACAAAATTTGGAATTAAAAGATTTGATTTCTTGTGCTAAAAAATATTTTATTCAAGAAAATTCAACTACGGT
AATTCTAAGAAAGGATTCAA

Downstream 100 bases:

>100_bases
TGAATACAGAATTTCAAGGAAAAACTTTAGTGATTAGCGGTGGAACTCGCGGGATAGGCAAAGCTATAGTTTATGAATTT
GCTAAAGTGGGTGCAAATAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHRTCIEIAVETCKGTKVKVLAG
AGSNATHEAVGLAKFAKEHGADGILSVVPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCE
NIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDEL
YNINKILFCESNPIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF

Sequences:

>Translated_298_residues
MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHRTCIEIAVETCKGTKVKVLAG
AGSNATHEAVGLAKFAKEHGADGILSVVPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCE
NIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDEL
YNINKILFCESNPIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF
>Mature_298_residues
MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHRTCIEIAVETCKGTKVKVLAG
AGSNATHEAVGLAKFAKEHGADGILSVVPYYNKPTQQGLYEHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCE
NIYGVKEASGNIDKCVDLLAHEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDEL
YNINKILFCESNPIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=204, Percent_Identity=25, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI13540533, Length=310, Percent_Identity=26.7741935483871, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=38.1443298969072, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI87082415, Length=283, Percent_Identity=28.6219081272085, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789620, Length=283, Percent_Identity=27.9151943462898, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786463, Length=283, Percent_Identity=28.6219081272085, Blast_Score=107, Evalue=7e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32699; Mature: 32699

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHR
CCCCEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEHHHHH
TCIEIAVETCKGTKVKVLAGAGSNATHEAVGLAKFAKEHGADGILSVVPYYNKPTQQGLY
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
EHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCENIYGVKEASGNIDKCVDLLA
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHH
HEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDEL
CCCCEEEEECCCCCCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YNINKILFCESNPIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDKNIIIGAMTALITPFKNGKVDEQSYARLIKRQIENGIDAVVPVGTTGESATLTHEEHR
CCCCEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEHHHHH
TCIEIAVETCKGTKVKVLAGAGSNATHEAVGLAKFAKEHGADGILSVVPYYNKPTQQGLY
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHH
EHYKAIAQSVDIPVLLYNVPGRTGCEISTDTIIKLFRDCENIYGVKEASGNIDKCVDLLA
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHH
HEPRMMLISGEDAINYPILSNGGKGVISVTSNLLPDMISALTHFALDENYKEAKKINDEL
CCCCEEEEECCCCCCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YNINKILFCESNPIPIKTAMYLAGLIESLEFRLPLCSPSKENFAKIEEVMKKYKIKGF
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA