BacMap

Definition	Campylobacter jejuni RM1221, complete genome.
Accession	NC_003912
Length	1,777,831

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The map label for this gene is fabL [H]

Identifier: 57237652

GI number: 57237652

Start: 838061

End: 838840

Strand: Direct

Name: fabL [H]

Synonym: CJE0898

Alternate gene names: 57237652

Gene position: 838061-838840 (Clockwise)

Preceding gene: 57237651

Following gene: 57237655

Centisome position: 47.14

GC content: 35.51

Gene sequence:

>780_bases
ATGAATACAGAATTTCAAGGAAAAACTTTAGTGATTAGCGGTGGAACTCGCGGGATAGGCAAAGCTATAGTTTATGAATT
TGCTAAAGTGGGTGCAAATATAGCTTTTACTTATAATTCTAATGCGCAAATTGCTGATGAAATGGTTCAAGATTTGGAGA
AAAATTATAAAATCAAAGCTAGAGCTTATGAGTTTAATATCTTAGAACCTGAAACCTATAAAGAACTTTTTGAAAAAATT
GATGTGGATTTTGATAGAGTGGATTATTTTATCTCAAATGCTATCATTTCAGGACGTGCGGTTGTAGGTGGCTATACTAA
ATTTATGAAGTTAAAACCAAAGGGAATTAATAACATTTTTACAGCCACAGTAAATGCTTTTGTTGTGGGCGCACAAGAAG
CAGCTAAAAGGATGGAAAAAGTAGGGGGTGGAAGCATTATTTCTATCTCATCTACAGGAAATTTAGTGTATATAGAAAAT
TATTCAGGTCATGGTACAGCAAAAGCCGCTGTAGAAGCTATGGCAAGATATGCGGCTACTGAACTTGGAGAAAAAAATAT
CCGTGTAAATGTCGTAAGTGGTGGGCCTGTTGAAACTGATGCTTTAAGAGCTTTTACAAATTATGAAGAAGTAAAACAGG
CTACTATAAATTTAAGCCCTTTAAATCGCATGGGGCAGCCTGAAGATTTGGCTGGAGCATGTCTTTTTCTTTGTTCAAGT
AAGGCAAGTTGGGTGACAGGACATACTTTCATCGTTGATGGTGGTACAACTTTTAAATAA

Upstream 100 bases:

>100_bases
TAGAAAGTTTGGAATTTAGACTTCCTCTTTGTTCTCCAAGTAAGGAAAATTTTGCTAAAATTGAAGAAGTGATGAAAAAA
TATAAGATCAAAGGATTTTA

Downstream 100 bases:

>100_bases
AAATTAAGAAAAATCAATGGATTTTTCTTAAAAATGTTTTTCAATCAAGTTTTAATTTCCACCCTAAAAAAACACTTAAT
AATGCAAGTAAAAAAATAAA

Product: 7-alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNTEFQGKTLVISGGTRGIGKAIVYEFAKVGANIAFTYNSNAQIADEMVQDLEKNYKIKARAYEFNILEPETYKELFEKI
DVDFDRVDYFISNAIISGRAVVGGYTKFMKLKPKGINNIFTATVNAFVVGAQEAAKRMEKVGGGSIISISSTGNLVYIEN
YSGHGTAKAAVEAMARYAATELGEKNIRVNVVSGGPVETDALRAFTNYEEVKQATINLSPLNRMGQPEDLAGACLFLCSS
KASWVTGHTFIVDGGTTFK

Sequences:

>Translated_259_residues
MNTEFQGKTLVISGGTRGIGKAIVYEFAKVGANIAFTYNSNAQIADEMVQDLEKNYKIKARAYEFNILEPETYKELFEKI
DVDFDRVDYFISNAIISGRAVVGGYTKFMKLKPKGINNIFTATVNAFVVGAQEAAKRMEKVGGGSIISISSTGNLVYIEN
YSGHGTAKAAVEAMARYAATELGEKNIRVNVVSGGPVETDALRAFTNYEEVKQATINLSPLNRMGQPEDLAGACLFLCSS
KASWVTGHTFIVDGGTTFK
>Mature_259_residues
MNTEFQGKTLVISGGTRGIGKAIVYEFAKVGANIAFTYNSNAQIADEMVQDLEKNYKIKARAYEFNILEPETYKELFEKI
DVDFDRVDYFISNAIISGRAVVGGYTKFMKLKPKGINNIFTATVNAFVVGAQEAAKRMEKVGGGSIISISSTGNLVYIEN
YSGHGTAKAAVEAMARYAATELGEKNIRVNVVSGGPVETDALRAFTNYEEVKQATINLSPLNRMGQPEDLAGACLFLCSS
KASWVTGHTFIVDGGTTFK

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=27.3809523809524, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=26.0536398467433, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=25.8964143426295, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI126723750, Length=119, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=23.4375, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4503301, Length=154, Percent_Identity=32.4675324675325, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI66933014, Length=263, Percent_Identity=24.7148288973384, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=23.7735849056604, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=33.4645669291339, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=31.0756972111554, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=27.5590551181102, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=27.6264591439689, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=27.4193548387097, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI87082160, Length=251, Percent_Identity=27.8884462151394, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=28.1124497991968, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787545, Length=266, Percent_Identity=24.812030075188, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789208, Length=260, Percent_Identity=24.6153846153846, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786812, Length=273, Percent_Identity=24.1758241758242, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082100, Length=272, Percent_Identity=23.8970588235294, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=30.078125, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=29.1828793774319, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=265, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=27.9569892473118, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=26.953125, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=24.5967741935484, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=263, Percent_Identity=24.3346007604563, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=274, Percent_Identity=27.3722627737226, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=284, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=271, Percent_Identity=26.1992619926199, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=272, Percent_Identity=26.1029411764706, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=272, Percent_Identity=26.8382352941176, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508651, Length=258, Percent_Identity=25.968992248062, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=283, Percent_Identity=28.6219081272085, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=281, Percent_Identity=25.6227758007117, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=269, Percent_Identity=25.2788104089219, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=25.7352941176471, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=286, Percent_Identity=26.2237762237762, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=283, Percent_Identity=27.208480565371, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=269, Percent_Identity=27.5092936802974, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=283, Percent_Identity=25.0883392226148, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=28.4615384615385, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=27.34375, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI23397609, Length=259, Percent_Identity=25.8687258687259, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24643142, Length=257, Percent_Identity=25.2918287937743, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=25.6916996047431, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644337, Length=116, Percent_Identity=37.0689655172414, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=24.609375, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 28123; Mature: 28123

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEFQGKTLVISGGTRGIGKAIVYEFAKVGANIAFTYNSNAQIADEMVQDLEKNYKIKA
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCEEEE
RAYEFNILEPETYKELFEKIDVDFDRVDYFISNAIISGRAVVGGYTKFMKLKPKGINNIF
EEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHH
TATVNAFVVGAQEAAKRMEKVGGGSIISISSTGNLVYIENYSGHGTAKAAVEAMARYAAT
HEEHHHEEEEHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ELGEKNIRVNVVSGGPVETDALRAFTNYEEVKQATINLSPLNRMGQPEDLAGACLFLCSS
HCCCCCEEEEEEECCCCCHHHHHHHCCHHHHHHHEECCCCHHHCCCCCHHHHHHHHHHCC
KASWVTGHTFIVDGGTTFK
CCCEEECEEEEEECCCCCC
>Mature Secondary Structure
MNTEFQGKTLVISGGTRGIGKAIVYEFAKVGANIAFTYNSNAQIADEMVQDLEKNYKIKA
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCEEEE
RAYEFNILEPETYKELFEKIDVDFDRVDYFISNAIISGRAVVGGYTKFMKLKPKGINNIF
EEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCHHH
TATVNAFVVGAQEAAKRMEKVGGGSIISISSTGNLVYIENYSGHGTAKAAVEAMARYAAT
HEEHHHEEEEHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ELGEKNIRVNVVSGGPVETDALRAFTNYEEVKQATINLSPLNRMGQPEDLAGACLFLCSS
HCCCCCEEEEEEECCCCCHHHHHHHCCHHHHHHHEECCCCHHHCCCCCHHHHHHHHHHCC
KASWVTGHTFIVDGGTTFK
CCCEEECEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]