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The map label for this gene is pqqL [C]

Identifier: 57237650

GI number: 57237650

Start: 835922

End: 837172

Strand: Direct

Name: pqqL [C]

Synonym: CJE0896

Alternate gene names: 57237650

Gene position: 835922-837172 (Clockwise)

Preceding gene: 57237649

Following gene: 57237651

Centisome position: 47.02

GC content: 27.5

Gene sequence:

>1251_bases
ATGATTGCTTATGAAAAAATTCAATTAAAAAACAAGCTTGAAGTTTATGCTTTGCCTGTAAATAAAAATAGCGATGTGAT
TAGCGTTGATATTTTTTATAAAGTGGGTTCAAGAAATGAGATCATGGGAAAAAGCGGCATAGCTCATATGCTAGAACATT
TAAATTTTAAAAGTACTAAAAATTTAAAAGCTGGCGAATTTGATGAGATTGTTAAGGGTTTTGGTGGTGTGGATAATGCA
AGCACAGGTTTTGACTATACTCATTATTATATTAAATGTGCGAAGAAAAATTTAGATAAAGCTTTGGAACTTTTTGCAGA
ACTTATGGAGAATTTAAATTTAAAAGATGAAGAATTTCAGCCTGAAAGAGCAGTGGTTTTAGAAGAGCGTAGATGGAGAA
CAGATAATAATCCTTTGGGATATCTTTATTTTAGGCTTTTTAATCACGCATTTATGTATCATCCTTATCATTGGACTCCT
ATAGGTTTTTTTAAAGATATAGAAAATTGGAGTATTGAAGATATTAAAGAATTTCATAGTATTTATTATCAACCTAAAAA
TGCGATTTTACTTGTAAGTGGCGATATAGAAAGTAAAGAAGTTTTTGAGCTTTCAAAAAAACATTTTGAAAAGATTAAAA
ATACTAAGACTATACCTAAAATTCACACAAAAGAGCCTAAGCAAGATGGAGCAAAAAGAATATATTTGCATAAAAACTCA
GATACTGAACTATTAGCCCTTGCTTATAAAATTCCAAATTTCAAGCACAAAGATATACCTGCTTTAAATGCTTTATCCGA
GCTTTTAGGAAGTGGGAAAAGTTCTTTAATGAGTGAAATTTTGATTGATAAATTAAATTTAATCAATGATTATTATGCTT
ATGTTAATGATTGTATAGATGACAATTTATTTATTTTTATTTGTAATTGTAATCCCAATGTTAATGCAGAAAAAGTAGAA
AAAGAACTTTTAAAAATCATTGATAAACTTAAAATGGGTAAAATTTCTCAAAAAGATTTGCAAAGAGTGAAAAATAATGT
CAAAAGCGATTTTATTTTCTCACTTAACAATGCTAGTGCAGTGGCAAATATTTATGGTTCATATCTAGCAAGAGGAGATA
TCAATCCTTTGTTAAATTATGAGAAAGATATACAAAATTTGGAATTAAAAGATTTGATTTCTTGTGCTAAAAAATATTTT
ATTCAAGAAAATTCAACTACGGTAATTCTAAGAAAGGATTCAAATGGATAA

Upstream 100 bases:

>100_bases
AAGGTCCTTCTTTGGTAAAAAATATCAATCAAAATCTTATAGAGCTTTTAAGAAAAGATGGTTTTTTACACATTAGCGAA
GCTGTTGGGGTAAATTTAAA

Downstream 100 bases:

>100_bases
AAATATTATTATTGGGGCAATGACGGCCCTTATTACACCGTTTAAAAATGGAAAAGTTGATGAGCAAAGTTATGCAAGAT
TGATTAAAAGGCAAATAGAA

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MIAYEKIQLKNKLEVYALPVNKNSDVISVDIFYKVGSRNEIMGKSGIAHMLEHLNFKSTKNLKAGEFDEIVKGFGGVDNA
STGFDYTHYYIKCAKKNLDKALELFAELMENLNLKDEEFQPERAVVLEERRWRTDNNPLGYLYFRLFNHAFMYHPYHWTP
IGFFKDIENWSIEDIKEFHSIYYQPKNAILLVSGDIESKEVFELSKKHFEKIKNTKTIPKIHTKEPKQDGAKRIYLHKNS
DTELLALAYKIPNFKHKDIPALNALSELLGSGKSSLMSEILIDKLNLINDYYAYVNDCIDDNLFIFICNCNPNVNAEKVE
KELLKIIDKLKMGKISQKDLQRVKNNVKSDFIFSLNNASAVANIYGSYLARGDINPLLNYEKDIQNLELKDLISCAKKYF
IQENSTTVILRKDSNG

Sequences:

>Translated_416_residues
MIAYEKIQLKNKLEVYALPVNKNSDVISVDIFYKVGSRNEIMGKSGIAHMLEHLNFKSTKNLKAGEFDEIVKGFGGVDNA
STGFDYTHYYIKCAKKNLDKALELFAELMENLNLKDEEFQPERAVVLEERRWRTDNNPLGYLYFRLFNHAFMYHPYHWTP
IGFFKDIENWSIEDIKEFHSIYYQPKNAILLVSGDIESKEVFELSKKHFEKIKNTKTIPKIHTKEPKQDGAKRIYLHKNS
DTELLALAYKIPNFKHKDIPALNALSELLGSGKSSLMSEILIDKLNLINDYYAYVNDCIDDNLFIFICNCNPNVNAEKVE
KELLKIIDKLKMGKISQKDLQRVKNNVKSDFIFSLNNASAVANIYGSYLARGDINPLLNYEKDIQNLELKDLISCAKKYF
IQENSTTVILRKDSNG
>Mature_416_residues
MIAYEKIQLKNKLEVYALPVNKNSDVISVDIFYKVGSRNEIMGKSGIAHMLEHLNFKSTKNLKAGEFDEIVKGFGGVDNA
STGFDYTHYYIKCAKKNLDKALELFAELMENLNLKDEEFQPERAVVLEERRWRTDNNPLGYLYFRLFNHAFMYHPYHWTP
IGFFKDIENWSIEDIKEFHSIYYQPKNAILLVSGDIESKEVFELSKKHFEKIKNTKTIPKIHTKEPKQDGAKRIYLHKNS
DTELLALAYKIPNFKHKDIPALNALSELLGSGKSSLMSEILIDKLNLINDYYAYVNDCIDDNLFIFICNCNPNVNAEKVE
KELLKIIDKLKMGKISQKDLQRVKNNVKSDFIFSLNNASAVANIYGSYLARGDINPLLNYEKDIQNLELKDLISCAKKYF
IQENSTTVILRKDSNG

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=409, Percent_Identity=23.4718826405868, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI94538354, Length=399, Percent_Identity=23.0576441102757, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1787770, Length=222, Percent_Identity=28.3783783783784, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71999683, Length=245, Percent_Identity=23.6734693877551, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17553678, Length=272, Percent_Identity=25, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323192, Length=357, Percent_Identity=23.5294117647059, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21357875, Length=414, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646943, Length=414, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48060; Mature: 48060

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAYEKIQLKNKLEVYALPVNKNSDVISVDIFYKVGSRNEIMGKSGIAHMLEHLNFKSTK
CCCCHHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCC
NLKAGEFDEIVKGFGGVDNASTGFDYTHYYIKCAKKNLDKALELFAELMENLNLKDEEFQ
CCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PERAVVLEERRWRTDNNPLGYLYFRLFNHAFMYHPYHWTPIGFFKDIENWSIEDIKEFHS
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCCCHHHHHHHHH
IYYQPKNAILLVSGDIESKEVFELSKKHFEKIKNTKTIPKIHTKEPKQDGAKRIYLHKNS
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCC
DTELLALAYKIPNFKHKDIPALNALSELLGSGKSSLMSEILIDKLNLINDYYAYVNDCID
CCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNLFIFICNCNPNVNAEKVEKELLKIIDKLKMGKISQKDLQRVKNNVKSDFIFSLNNASA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHH
VANIYGSYLARGDINPLLNYEKDIQNLELKDLISCAKKYFIQENSTTVILRKDSNG
HHHHHHHHHHCCCCCHHHCCHHHHHCCCHHHHHHHHHHHHEECCCEEEEEEECCCC
>Mature Secondary Structure
MIAYEKIQLKNKLEVYALPVNKNSDVISVDIFYKVGSRNEIMGKSGIAHMLEHLNFKSTK
CCCCHHHHCCCCEEEEEEECCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCC
NLKAGEFDEIVKGFGGVDNASTGFDYTHYYIKCAKKNLDKALELFAELMENLNLKDEEFQ
CCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PERAVVLEERRWRTDNNPLGYLYFRLFNHAFMYHPYHWTPIGFFKDIENWSIEDIKEFHS
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCCCCCHHHHHCCCCCHHHHHHHHH
IYYQPKNAILLVSGDIESKEVFELSKKHFEKIKNTKTIPKIHTKEPKQDGAKRIYLHKNS
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCC
DTELLALAYKIPNFKHKDIPALNALSELLGSGKSSLMSEILIDKLNLINDYYAYVNDCID
CCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DNLFIFICNCNPNVNAEKVEKELLKIIDKLKMGKISQKDLQRVKNNVKSDFIFSLNNASA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEECCCHH
VANIYGSYLARGDINPLLNYEKDIQNLELKDLISCAKKYFIQENSTTVILRKDSNG
HHHHHHHHHHCCCCCHHHCCHHHHHCCCHHHHHHHHHHHHEECCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]