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The map label for this gene is 21226797

Identifier: 21226797

GI number: 21226797

Start: 833137

End: 835050

Strand: Direct

Name: 21226797

Synonym: MM_0695

Alternate gene names: NA

Gene position: 833137-835050 (Clockwise)

Preceding gene: 21226796

Following gene: 21226799

Centisome position: 20.34

GC content: 47.6

Gene sequence:

>1914_bases
ATGCCTATAGAAGACGTGCTATTAGACCTCAAACACAAAATTGAGAAAAACCTACCCGCAGGCGTTACTATTACCGACGT
CGAATTTGAGGGCCCTCAGCTTGTTCTGTATACCGAGGAGCCCAGAAAATTCGCTGATGACGGGAATATTATCCGCAACC
TGGCAAAAGAACTCAGGACGCGGATTGCTATGCGGCCTGATCCCAGGGTTCTCGCAACTCCTGAGGACTCTATTTCTATA
ATTGAAGAAGTTGTTCCAAAAGAATCCGTAATCTCGAGCTACTATTTTGACCCTGATTCAGGAGAAGTAATTATCGAAGC
CGAAAAGCCCGGGCTTGTAATAGGAAAACATGGCGCAACCCTCAGAGAGATTACAAAGCAGATTGGCTGGATTCCAAAAG
TTGTCAGGACACCTCCTATAAAGTCACGTACGGTAAAAAACATACGGGAGTTCATGCGGAACAACCTCAAAGAAAGGAAG
GAAATCCTGAAAACAGTGGGGAGGAAAATTCACAGGGAGTGTACTTCAAAAGACCAGTGGGTAAGGGTTACAGCCCTTGG
GGGATGTAAAGAAGTAGGAAGAAGCTGCTTTTTGCTTTCTACACCTGAATCCAGAATCCTGATTGACTGCGGAGTCAATG
TGGGATCTGATGAAAACATGACGCCTTACCTTTATGTTCCTGAAGTTTTTCCATTAAACCAGATAGATGCCGTGATAGTT
ACCCACGCTCACCTTGACCACCAGGGACTTGTCCCCCTGCTTTTCAAGTACGGGTACGAAGGACCTGTCTACTGTACTCC
TCCAACAAGAGACCTTATGGTGCTGCTCCAGCTCGACTACATAGATGTGGCAGCTAAAGAAGGGAAGAAGATTCCCTATG
AATCAGGGATGGTAGCAAAAACCCTCAAACACACCATACCTCTGGACTACGAGGAAGTAACAGACATAGCCCCCGACATA
AAACTGACTTTCCATAATGCAGGTCATATCCTGGGCTCAGCTATTTCCCATTTCCATATAGGAGACGGCCTCCATAATGT
GGTCTTTACAGGAGACTACAAATATGAGAAAACCAGGCTTTTTGACCCTGCTGTCAACAAGTTCCCGAGGGTCGAAACGG
TCATCAGTGAAGCTACTTATGGAAATGCAAACGCTTTCCAGCCTGCACTTAAAGATGCGGAAAAGCACCTGCAGATGGTC
GTAAAGAATACCATTGAGCGCGGAGGAATTGCAGTCATTCCTGCTTTTGCTGTGGGCAGAAGCCAGGAAGTTATGATTGT
GCTCGAAGAGTCCATAAGGAAAGGACTTATCCCCGAAGTTCCGGTCTACCTTGACGGAATGATCTGGGAAGCAACTGCAA
TCCATGCAACTCATCCGGAATACCTGAATAATGACCTGAGGAAACTGATCTTCCAGAAAGGCCAGAACCCCTTCCTGTCA
GAGTGCTTCAAGCCTGTGGACTCACATGAAGCACGCCAGAAGATCATCCAGAACCCTCAGCCCTGCGTAATCCTGGCAAC
TTCGGGCATGATGAACGGAGGCCCTGTTATGGAGTATTTCAAGGCTTTTGCAGAAGACCCGCGCAATACCCTTGTGTTTG
TGGGCTATCAGGCTGACGGGACAATAGGGCGCAGGATCCAGAAGGGATGGAAAGAAATTCCGATGACAGGGAAGAACGGA
AGCACCGAAATGCTGAAAATGAACATGGAGGTGCAGGTTGTAGACGGATTCTCAGGCCACTCGGACAGGAGGCAGCTTAT
GGAATATGTTAAAAGGATGCAGCCCCGCCCGGAAAGAGTATTCACGGAGCACGGAGATGAAAAAGCCTGTGTTGACCTCG
CAAGTTCCGTTTACAAGAAACTGAAGATAGAGACACGTGCGCTCACAAACCTCGAAACCGTAAGACTGCTGTGA

Upstream 100 bases:

>100_bases
GTTGGTTTTTTATTTCATCATACAAACTAACACCTTTTTCAAATATTATTTTTTCAACATCCAGATCTTTTTGATTTTTT
GATAAAAAGGAAGATTCTTA

Downstream 100 bases:

>100_bases
TCCCTGGTGAACCACACCTTTTTTTGAAAAATTTGAATAAAAAAGAATACTGAAGGATTCCCGGGTAAAGATTAAAAGCA
GGTAAAGAGATGTACAGAAA

Product: cleavage and polyadenylation specificity factor 100 kD subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MPIEDVLLDLKHKIEKNLPAGVTITDVEFEGPQLVLYTEEPRKFADDGNIIRNLAKELRTRIAMRPDPRVLATPEDSISI
IEEVVPKESVISSYYFDPDSGEVIIEAEKPGLVIGKHGATLREITKQIGWIPKVVRTPPIKSRTVKNIREFMRNNLKERK
EILKTVGRKIHRECTSKDQWVRVTALGGCKEVGRSCFLLSTPESRILIDCGVNVGSDENMTPYLYVPEVFPLNQIDAVIV
THAHLDHQGLVPLLFKYGYEGPVYCTPPTRDLMVLLQLDYIDVAAKEGKKIPYESGMVAKTLKHTIPLDYEEVTDIAPDI
KLTFHNAGHILGSAISHFHIGDGLHNVVFTGDYKYEKTRLFDPAVNKFPRVETVISEATYGNANAFQPALKDAEKHLQMV
VKNTIERGGIAVIPAFAVGRSQEVMIVLEESIRKGLIPEVPVYLDGMIWEATAIHATHPEYLNNDLRKLIFQKGQNPFLS
ECFKPVDSHEARQKIIQNPQPCVILATSGMMNGGPVMEYFKAFAEDPRNTLVFVGYQADGTIGRRIQKGWKEIPMTGKNG
STEMLKMNMEVQVVDGFSGHSDRRQLMEYVKRMQPRPERVFTEHGDEKACVDLASSVYKKLKIETRALTNLETVRLL

Sequences:

>Translated_637_residues
MPIEDVLLDLKHKIEKNLPAGVTITDVEFEGPQLVLYTEEPRKFADDGNIIRNLAKELRTRIAMRPDPRVLATPEDSISI
IEEVVPKESVISSYYFDPDSGEVIIEAEKPGLVIGKHGATLREITKQIGWIPKVVRTPPIKSRTVKNIREFMRNNLKERK
EILKTVGRKIHRECTSKDQWVRVTALGGCKEVGRSCFLLSTPESRILIDCGVNVGSDENMTPYLYVPEVFPLNQIDAVIV
THAHLDHQGLVPLLFKYGYEGPVYCTPPTRDLMVLLQLDYIDVAAKEGKKIPYESGMVAKTLKHTIPLDYEEVTDIAPDI
KLTFHNAGHILGSAISHFHIGDGLHNVVFTGDYKYEKTRLFDPAVNKFPRVETVISEATYGNANAFQPALKDAEKHLQMV
VKNTIERGGIAVIPAFAVGRSQEVMIVLEESIRKGLIPEVPVYLDGMIWEATAIHATHPEYLNNDLRKLIFQKGQNPFLS
ECFKPVDSHEARQKIIQNPQPCVILATSGMMNGGPVMEYFKAFAEDPRNTLVFVGYQADGTIGRRIQKGWKEIPMTGKNG
STEMLKMNMEVQVVDGFSGHSDRRQLMEYVKRMQPRPERVFTEHGDEKACVDLASSVYKKLKIETRALTNLETVRLL
>Mature_636_residues
PIEDVLLDLKHKIEKNLPAGVTITDVEFEGPQLVLYTEEPRKFADDGNIIRNLAKELRTRIAMRPDPRVLATPEDSISII
EEVVPKESVISSYYFDPDSGEVIIEAEKPGLVIGKHGATLREITKQIGWIPKVVRTPPIKSRTVKNIREFMRNNLKERKE
ILKTVGRKIHRECTSKDQWVRVTALGGCKEVGRSCFLLSTPESRILIDCGVNVGSDENMTPYLYVPEVFPLNQIDAVIVT
HAHLDHQGLVPLLFKYGYEGPVYCTPPTRDLMVLLQLDYIDVAAKEGKKIPYESGMVAKTLKHTIPLDYEEVTDIAPDIK
LTFHNAGHILGSAISHFHIGDGLHNVVFTGDYKYEKTRLFDPAVNKFPRVETVISEATYGNANAFQPALKDAEKHLQMVV
KNTIERGGIAVIPAFAVGRSQEVMIVLEESIRKGLIPEVPVYLDGMIWEATAIHATHPEYLNNDLRKLIFQKGQNPFLSE
CFKPVDSHEARQKIIQNPQPCVILATSGMMNGGPVMEYFKAFAEDPRNTLVFVGYQADGTIGRRIQKGWKEIPMTGKNGS
TEMLKMNMEVQVVDGFSGHSDRRQLMEYVKRMQPRPERVFTEHGDEKACVDLASSVYKKLKIETRALTNLETVRLL

Specific function: Unknown

COG id: COG1782

COG function: function code R; Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI33300633, Length=462, Percent_Identity=31.1688311688312, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI7706427, Length=461, Percent_Identity=27.9826464208243, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI34101288, Length=372, Percent_Identity=22.3118279569892, Blast_Score=92, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI32564696, Length=461, Percent_Identity=29.7180043383948, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566029, Length=466, Percent_Identity=30.2575107296137, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17559452, Length=443, Percent_Identity=23.7020316027088, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323307, Length=423, Percent_Identity=27.1867612293144, Blast_Score=156, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21358523, Length=460, Percent_Identity=30.8695652173913, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24648013, Length=431, Percent_Identity=27.3781902552204, Blast_Score=186, Evalue=6e-47,
Organism=Drosophila melanogaster, GI21358013, Length=372, Percent_Identity=22.0430107526882, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR004087
- InterPro:   IPR019975
- InterPro:   IPR004044
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF07650 KH_2; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 71751; Mature: 71620

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50084 KH_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIEDVLLDLKHKIEKNLPAGVTITDVEFEGPQLVLYTEEPRKFADDGNIIRNLAKELRT
CCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
RIAMRPDPRVLATPEDSISIIEEVVPKESVISSYYFDPDSGEVIIEAEKPGLVIGKHGAT
HHCCCCCCCEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCH
LREITKQIGWIPKVVRTPPIKSRTVKNIREFMRNNLKERKEILKTVGRKIHRECTSKDQW
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VRVTALGGCKEVGRSCFLLSTPESRILIDCGVNVGSDENMTPYLYVPEVFPLNQIDAVIV
EEEEECCCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEE
THAHLDHQGLVPLLFKYGYEGPVYCTPPTRDLMVLLQLDYIDVAAKEGKKIPYESGMVAK
EEECCCCCCHHHHHHHCCCCCCEEECCCCHHEEEEEEECHHHHHHHCCCCCCCCCCHHHH
TLKHTIPLDYEEVTDIAPDIKLTFHNAGHILGSAISHFHIGDGLHNVVFTGDYKYEKTRL
HHHHHCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHEE
FDPAVNKFPRVETVISEATYGNANAFQPALKDAEKHLQMVVKNTIERGGIAVIPAFAVGR
CCHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCC
SQEVMIVLEESIRKGLIPEVPVYLDGMIWEATAIHATHPEYLNNDLRKLIFQKGQNPFLS
CCCEEEEEEHHHHCCCCCCCCHHHCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
ECFKPVDSHEARQKIIQNPQPCVILATSGMMNGGPVMEYFKAFAEDPRNTLVFVGYQADG
HHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCC
TIGRRIQKGWKEIPMTGKNGSTEMLKMNMEVQVVDGFSGHSDRRQLMEYVKRMQPRPERV
HHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHH
FTEHGDEKACVDLASSVYKKLKIETRALTNLETVRLL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECC
>Mature Secondary Structure 
PIEDVLLDLKHKIEKNLPAGVTITDVEFEGPQLVLYTEEPRKFADDGNIIRNLAKELRT
CHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
RIAMRPDPRVLATPEDSISIIEEVVPKESVISSYYFDPDSGEVIIEAEKPGLVIGKHGAT
HHCCCCCCCEEECCCHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCH
LREITKQIGWIPKVVRTPPIKSRTVKNIREFMRNNLKERKEILKTVGRKIHRECTSKDQW
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VRVTALGGCKEVGRSCFLLSTPESRILIDCGVNVGSDENMTPYLYVPEVFPLNQIDAVIV
EEEEECCCHHHHCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCEEEE
THAHLDHQGLVPLLFKYGYEGPVYCTPPTRDLMVLLQLDYIDVAAKEGKKIPYESGMVAK
EEECCCCCCHHHHHHHCCCCCCEEECCCCHHEEEEEEECHHHHHHHCCCCCCCCCCHHHH
TLKHTIPLDYEEVTDIAPDIKLTFHNAGHILGSAISHFHIGDGLHNVVFTGDYKYEKTRL
HHHHHCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHEE
FDPAVNKFPRVETVISEATYGNANAFQPALKDAEKHLQMVVKNTIERGGIAVIPAFAVGR
CCHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCC
SQEVMIVLEESIRKGLIPEVPVYLDGMIWEATAIHATHPEYLNNDLRKLIFQKGQNPFLS
CCCEEEEEEHHHHCCCCCCCCHHHCCEEEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
ECFKPVDSHEARQKIIQNPQPCVILATSGMMNGGPVMEYFKAFAEDPRNTLVFVGYQADG
HHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCC
TIGRRIQKGWKEIPMTGKNGSTEMLKMNMEVQVVDGFSGHSDRRQLMEYVKRMQPRPERV
HHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCHHH
FTEHGDEKACVDLASSVYKKLKIETRALTNLETVRLL
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]