BacMap

Definition	Methanosarcina mazei Go1 chromosome, complete genome.
Accession	NC_003901
Length	4,096,345

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The map label for this gene is psmB [H]

Identifier: 21226796

GI number: 21226796

Start: 832393

End: 833025

Strand: Direct

Name: psmB [H]

Synonym: MM_0694

Alternate gene names: 21226796

Gene position: 832393-833025 (Clockwise)

Preceding gene: 21226795

Following gene: 21226797

Centisome position: 20.32

GC content: 45.81

Gene sequence:

>633_bases
ATGGATAATGACAAATATTTAAAGGGCACAACTACCGTAGGAGTAGTTTGTACCGACGGAATTGTGCTCGCAAGTGAACA
GCGAGCCACTATGGGGCATTTCATCGCAAGCAAAACTGCAAAGAAAGTTTACCAGATAGATGACCTGGTAGGGATGACCA
CTGCCGGTTCGGTAGGGGACGCTCAGCAGCTCGTGCGATTGGTAAGTGTGGAATCACAGCTCTACAAGATGCGCAGGAAC
GAATCCATGACGATCAAAGGGATTGCCACTTTGATGTCCAATTTCTTGAATGCTAACCGCTATTATCCTATGATGGTTCA
GCTCCTTATCGGAGGGGTTGACAAAAACGGTCCTGCAATCTACTCACTGGACCCTATGGGAGGAAGCATTGAAGAGACAA
GAATCTCAGCAACCGGCTCGGGTTCTCCCATGGCCTACGGAGTGCTGGAAGACCAGTACAGAGAGGATATAGCTGTAAAA
GAAGGTCTTGATCTTGCGATTCGAGCAATTCACAATGCAACGAAAAGAGACTCAGCTTCCGGAGAAAATATCGATGTAGT
CGTAATTACAAAGGAGGCATTCAAAAGGTTGGATCCTGAAGAAGTAAAATCCAGAAGAGCTTTATTAAACTAA

Upstream 100 bases:

>100_bases
ATTGCTAAATCCTGCGATTTAAGCTAAAAATGCTCACCTCAACTAAAACATTTTTTTTAGCGCCATTTTCTCATTTTCAG
CTTATTATGAGGGTATGTTT

Downstream 100 bases:

>100_bases
ATAATTTAATTGTTGGTTTTTTATTTCATCATACAAACTAACACCTTTTTCAAATATTATTTTTTCAACATCCAGATCTT
TTTGATTTTTTGATAAAAAG

Product: proteasome subunit beta

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PsmB [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGDAQQLVRLVSVESQLYKMRRN
ESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAIYSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVK
EGLDLAIRAIHNATKRDSASGENIDVVVITKEAFKRLDPEEVKSRRALLN

Sequences:

>Translated_210_residues
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGDAQQLVRLVSVESQLYKMRRN
ESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAIYSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVK
EGLDLAIRAIHNATKRDSASGENIDVVVITKEAFKRLDPEEVKSRRALLN
>Mature_210_residues
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGDAQQLVRLVSVESQLYKMRRN
ESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAIYSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVK
EGLDLAIRAIHNATKRDSASGENIDVVVITKEAFKRLDPEEVKSRRALLN

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family [H]

Homologues:

Organism=Homo sapiens, GI4506201, Length=196, Percent_Identity=33.6734693877551, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI73747875, Length=199, Percent_Identity=32.1608040201005, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4758970, Length=199, Percent_Identity=32.1608040201005, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4506203, Length=198, Percent_Identity=32.8282828282828, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4506193, Length=210, Percent_Identity=29.5238095238095, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI4506191, Length=190, Percent_Identity=30.5263157894737, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI153791216, Length=190, Percent_Identity=28.4210526315789, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI195539356, Length=148, Percent_Identity=31.0810810810811, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI23110925, Length=189, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI23110942, Length=164, Percent_Identity=29.2682926829268, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4506189, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI68303563, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI222144262, Length=121, Percent_Identity=31.404958677686, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI156713442, Length=188, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4506185, Length=188, Percent_Identity=25, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4506181, Length=203, Percent_Identity=26.1083743842365, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI68303561, Length=210, Percent_Identity=27.6190476190476, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508499, Length=205, Percent_Identity=33.6585365853659, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17508493, Length=189, Percent_Identity=28.042328042328, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541700, Length=196, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17508495, Length=199, Percent_Identity=30.1507537688442, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17508491, Length=191, Percent_Identity=30.8900523560209, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554384, Length=198, Percent_Identity=25.2525252525253, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17535357, Length=198, Percent_Identity=25.7575757575758, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325360, Length=191, Percent_Identity=31.413612565445, Blast_Score=104, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322459, Length=189, Percent_Identity=28.042328042328, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324731, Length=182, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320849, Length=192, Percent_Identity=26.0416666666667, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324938, Length=170, Percent_Identity=30, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319430, Length=207, Percent_Identity=24.6376811594203, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321574, Length=204, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355573, Length=186, Percent_Identity=34.4086021505376, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24652553, Length=186, Percent_Identity=34.4086021505376, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20130281, Length=197, Percent_Identity=31.9796954314721, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24584895, Length=174, Percent_Identity=33.9080459770115, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24664391, Length=195, Percent_Identity=30.2564102564103, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24639979, Length=199, Percent_Identity=29.1457286432161, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24654391, Length=209, Percent_Identity=28.7081339712919, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24654389, Length=209, Percent_Identity=28.7081339712919, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653999, Length=189, Percent_Identity=25.3968253968254, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737927, Length=199, Percent_Identity=26.1306532663317, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28573221, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24581176, Length=200, Percent_Identity=26, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17933602, Length=183, Percent_Identity=28.4153005464481, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737605, Length=199, Percent_Identity=24.6231155778894, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922898, Length=140, Percent_Identity=30, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921232, Length=195, Percent_Identity=29.7435897435897, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 22886; Mature: 22886

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00854 PROTEASOME_B

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGD
CCCCCEEECCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQQLVRLVSVESQLYKMRRNESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAI
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEE
YSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVKEGLDLAIRAIHNATKRDSAS
EEECCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GENIDVVVITKEAFKRLDPEEVKSRRALLN
CCCEEEEEEEHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDNDKYLKGTTTVGVVCTDGIVLASEQRATMGHFIASKTAKKVYQIDDLVGMTTAGSVGD
CCCCCEEECCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AQQLVRLVSVESQLYKMRRNESMTIKGIATLMSNFLNANRYYPMMVQLLIGGVDKNGPAI
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEE
YSLDPMGGSIEETRISATGSGSPMAYGVLEDQYREDIAVKEGLDLAIRAIHNATKRDSAS
EEECCCCCCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
GENIDVVVITKEAFKRLDPEEVKSRRALLN
CCCEEEEEEEHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA