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The map label for this gene is argC

Identifier: 21226578

GI number: 21226578

Start: 600893

End: 601915

Strand: Reverse

Name: argC

Synonym: MM_0476

Alternate gene names: 21226578

Gene position: 601915-600893 (Counterclockwise)

Preceding gene: 21226579

Following gene: 21226577

Centisome position: 14.69

GC content: 50.44

Gene sequence:

>1023_bases
GTGAATACCATGATCAAGGCAGGAATTATAGGAGCTTCCGGATATACAGGAGGAGAACTCCTGCGCTTACTTGTAAGCCA
CCCCGATGTCAGTCTTGAACTGGCGACCTCCCGGAGTCTTGCAGGAAAACCCGTAGCAAGCACTCACAGGCACCTCGAAG
GCTTTCTGGACCTGAAGTACGAAAACCCCGGGCTTGAAGAAATCAGGGAGCGTTGTGACTTGGTTTTTTTGGCGGTGCCT
CACGGGACCGGTATGAATTACGTCCCCGAACTGCTCGACGGTAGCACAAAGGTAATCGACCTCAGCGCGGACTACAGGCT
TGATATTCCGGTATTTGAAAAAATTTATGGAATAAAACACAGCGACCCGAGGAATGCAGTGTACGGGCTTGTAGAACTTC
ACCCTGAAGCAGCCAGAGAATATTTTGTGGCAAATCCGGGCTGTTTCCCTACAGGAGCGATTCTCTCAGCAGCCCCGCTT
GCAGCAGCCGGGCTGATAGATATCGCGGTATTCGACTCCAAAACAGGGATTTCAGGGGCAGGAATTTCTCCAACTGAAAC
CTCGCATTACCCGAATCTTGCAGAAAATATTGTCCCGTATAAACTTACAGCTCACAGGCACAGGGCTGAGATCGTACAGG
AACTAACGAGGCTTGACGGAAATCTCCGAAACATCAGCTTCACTCCGCATGTAATCCCAACCATCAGAGGGATCTCTACA
ACTGCACACCTCTTTACAAAAGAGCCTCTTTCGACCGAAGATGTCAGGGGAATTTATGAGGAGTTTTACAGGGATAAGCC
TTTTGTCCGGCTCCCGGGAGGAGTCCCGTCCCTTACTGCGGTCAGGGGTTCTAACTTCTGTGATATTGGCTTTGAAGCAG
ATAAAGAGAATAACAGGGTTGTTGTACTCTCGGCAATCGATAATCTTGTCAAAGGCGCATCCGGGCAGGCTATCCAGAAC
ATGAACCTTATGTTCGGGCTGGTTGAGACCCGCGGTCTCTGGACGCCTGCCACAGCTCCATAA

Upstream 100 bases:

>100_bases
TCTTATGAGCCATTATCTGCGTGCCAGCAACCCCCAGATCCTTCTCTCTTGTTTTTTTCGATAACAAGCTTAATTATCTT
GTATTGACATTACACTGGCA

Downstream 100 bases:

>100_bases
ACGCAGAGCAGGCGAGAATATATAACTGGTGACGGATAAAAATAAAGAATGGAATTTATTTTGGGGTAGTCCGATGAAAG
TAAAAGATGTCATGAATCCT

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MNTMIKAGIIGASGYTGGELLRLLVSHPDVSLELATSRSLAGKPVASTHRHLEGFLDLKYENPGLEEIRERCDLVFLAVP
HGTGMNYVPELLDGSTKVIDLSADYRLDIPVFEKIYGIKHSDPRNAVYGLVELHPEAAREYFVANPGCFPTGAILSAAPL
AAAGLIDIAVFDSKTGISGAGISPTETSHYPNLAENIVPYKLTAHRHRAEIVQELTRLDGNLRNISFTPHVIPTIRGIST
TAHLFTKEPLSTEDVRGIYEEFYRDKPFVRLPGGVPSLTAVRGSNFCDIGFEADKENNRVVVLSAIDNLVKGASGQAIQN
MNLMFGLVETRGLWTPATAP

Sequences:

>Translated_340_residues
MNTMIKAGIIGASGYTGGELLRLLVSHPDVSLELATSRSLAGKPVASTHRHLEGFLDLKYENPGLEEIRERCDLVFLAVP
HGTGMNYVPELLDGSTKVIDLSADYRLDIPVFEKIYGIKHSDPRNAVYGLVELHPEAAREYFVANPGCFPTGAILSAAPL
AAAGLIDIAVFDSKTGISGAGISPTETSHYPNLAENIVPYKLTAHRHRAEIVQELTRLDGNLRNISFTPHVIPTIRGIST
TAHLFTKEPLSTEDVRGIYEEFYRDKPFVRLPGGVPSLTAVRGSNFCDIGFEADKENNRVVVLSAIDNLVKGASGQAIQN
MNLMFGLVETRGLWTPATAP
>Mature_340_residues
MNTMIKAGIIGASGYTGGELLRLLVSHPDVSLELATSRSLAGKPVASTHRHLEGFLDLKYENPGLEEIRERCDLVFLAVP
HGTGMNYVPELLDGSTKVIDLSADYRLDIPVFEKIYGIKHSDPRNAVYGLVELHPEAAREYFVANPGCFPTGAILSAAPL
AAAGLIDIAVFDSKTGISGAGISPTETSHYPNLAENIVPYKLTAHRHRAEIVQELTRLDGNLRNISFTPHVIPTIRGIST
TAHLFTKEPLSTEDVRGIYEEFYRDKPFVRLPGGVPSLTAVRGSNFCDIGFEADKENNRVVVLSAIDNLVKGASGQAIQN
MNLMFGLVETRGLWTPATAP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=343, Percent_Identity=34.6938775510204, Blast_Score=174, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6320913, Length=339, Percent_Identity=30.9734513274336, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_METMA (Q8PZL6)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632500.1
- ProteinModelPortal:   Q8PZL6
- SMR:   Q8PZL6
- GeneID:   1478818
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0476
- NMPDR:   fig|192952.1.peg.476
- HOGENOM:   HBG294213
- OMA:   DTKKFME
- ProtClustDB:   PRK00436
- BioCyc:   MMAZ192952:MM0476-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 36889; Mature: 36889

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMIKAGIIGASGYTGGELLRLLVSHPDVSLELATSRSLAGKPVASTHRHLEGFLDLKY
CCCEEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEEEEE
ENPGLEEIRERCDLVFLAVPHGTGMNYVPELLDGSTKVIDLSADYRLDIPVFEKIYGIKH
CCCCHHHHHHHCCEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCEECCHHHHHHHCCCC
SDPRNAVYGLVELHPEAAREYFVANPGCFPTGAILSAAPLAAAGLIDIAVFDSKTGISGA
CCCCHHEEEEEEECHHHHHHEEEECCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCC
GISPTETSHYPNLAENIVPYKLTAHRHRAEIVQELTRLDGNLRNISFTPHVIPTIRGIST
CCCCCCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCH
TAHLFTKEPLSTEDVRGIYEEFYRDKPFVRLPGGVPSLTAVRGSNFCDIGFEADKENNRV
HHHEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCEEECCCCCCCCCCEE
VVLSAIDNLVKGASGQAIQNMNLMFGLVETRGLWTPATAP
EEEHHHHHHHCCCCCCHHHCCHHEEEEEHHCCCCCCCCCC
>Mature Secondary Structure
MNTMIKAGIIGASGYTGGELLRLLVSHPDVSLELATSRSLAGKPVASTHRHLEGFLDLKY
CCCEEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEEEEE
ENPGLEEIRERCDLVFLAVPHGTGMNYVPELLDGSTKVIDLSADYRLDIPVFEKIYGIKH
CCCCHHHHHHHCCEEEEEECCCCCCCHHHHHHCCCCEEEEECCCCEECCHHHHHHHCCCC
SDPRNAVYGLVELHPEAAREYFVANPGCFPTGAILSAAPLAAAGLIDIAVFDSKTGISGA
CCCCHHEEEEEEECHHHHHHEEEECCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCC
GISPTETSHYPNLAENIVPYKLTAHRHRAEIVQELTRLDGNLRNISFTPHVIPTIRGIST
CCCCCCCCCCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCH
TAHLFTKEPLSTEDVRGIYEEFYRDKPFVRLPGGVPSLTAVRGSNFCDIGFEADKENNRV
HHHEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCCEEEECCCCEEECCCCCCCCCCEE
VVLSAIDNLVKGASGQAIQNMNLMFGLVETRGLWTPATAP
EEEHHHHHHHCCCCCCHHHCCHHEEEEEHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824