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The map label for this gene is hemD [H]

Identifier: 21226410

GI number: 21226410

Start: 411390

End: 412199

Strand: Direct

Name: hemD [H]

Synonym: MM_0308

Alternate gene names: 21226410

Gene position: 411390-412199 (Clockwise)

Preceding gene: 21226409

Following gene: 21226411

Centisome position: 10.04

GC content: 45.56

Gene sequence:

>810_bases
GTGACAGGAGAAAGAAATATGGCAGAAGAGAAAATTCCCGTGCTTGCGATCATGAGGCCGGAAAGTTACCGCGAAAAATC
CGAAGCTATTGCCAGGGACTATGGATTTGAGCCTTTATGTGTCCCGATGATAAAGCTTGAAGGCATAAAAGATGACGGTT
TCGAGCCTTTTATTCAGAGGGTCATTGACGGGACTTCGGACTACGTTGTTTTCACAAGTGCAAACGGGATAACTTTCACA
CTGGATAAACTAACGGAAGATGAAAAGAAAAACTTCATCACAGCCCTTAAAAAAAGAAAAGTAATAGCAATCGGTCCCAA
CACGGAAAAAGAGCTTGTGAGAATAGGAATTGAGAACTCCTTCATGCCTGCGGATTACAGTTCCGAGGGAATCGTAGAAG
CTCTCTGTCCTGAAGTGAAAGGAAAAACTGTTGACCTTGCAAGGAGCGCTTATGGGGCAAAACTCTTAATAGACGGCCTT
GAAAAATGTGGGGCAACGGTTTACGAGACCCATGTATATACTCTCAGCATCCCTGAAGGAGCAGCCCAGAAAGAGCTCAT
AGAGCGCACCCTTTCGGGAGAGGTTGACGCCTTTGCCTTTACAAGCTCTATGATGGTCAGGGGATTTATGAAGCACGCAG
AAAACCTGGGAGCTTCAGAAGCTGTAAAAGAAATTCTCAGCAGGGCTGTTGTGGGCGCAATTGGGACTCCGACAGGAAAT
ACCCTGAAAAAACACGGGGTCAATGCAAACGTGATCCCTGATGAGTTCACCTTTGAAGCCCTTATAAAGGCTATGAAGAA
AGAGTTCTGA

Upstream 100 bases:

>100_bases
AAAAGTAAAAGCCCCTGCCATCACAGTCGTAGGAGAGGTAGTTAACCTGCACGAAATTCTAGGGGAACAGCTTACAGGGG
CTGAGTTTTAACTTGCTGAA

Downstream 100 bases:

>100_bases
AAAGTCGGTTCCAGAGCCGGTTAAAAATATTTCCAGTTAAAAAACAATATTTATTATAGTTCTGTGGAACAATCTGGTTC
TGGAAAACAATCTCACTTTT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTGERNMAEEKIPVLAIMRPESYREKSEAIARDYGFEPLCVPMIKLEGIKDDGFEPFIQRVIDGTSDYVVFTSANGITFT
LDKLTEDEKKNFITALKKRKVIAIGPNTEKELVRIGIENSFMPADYSSEGIVEALCPEVKGKTVDLARSAYGAKLLIDGL
EKCGATVYETHVYTLSIPEGAAQKELIERTLSGEVDAFAFTSSMMVRGFMKHAENLGASEAVKEILSRAVVGAIGTPTGN
TLKKHGVNANVIPDEFTFEALIKAMKKEF

Sequences:

>Translated_269_residues
MTGERNMAEEKIPVLAIMRPESYREKSEAIARDYGFEPLCVPMIKLEGIKDDGFEPFIQRVIDGTSDYVVFTSANGITFT
LDKLTEDEKKNFITALKKRKVIAIGPNTEKELVRIGIENSFMPADYSSEGIVEALCPEVKGKTVDLARSAYGAKLLIDGL
EKCGATVYETHVYTLSIPEGAAQKELIERTLSGEVDAFAFTSSMMVRGFMKHAENLGASEAVKEILSRAVVGAIGTPTGN
TLKKHGVNANVIPDEFTFEALIKAMKKEF
>Mature_268_residues
TGERNMAEEKIPVLAIMRPESYREKSEAIARDYGFEPLCVPMIKLEGIKDDGFEPFIQRVIDGTSDYVVFTSANGITFTL
DKLTEDEKKNFITALKKRKVIAIGPNTEKELVRIGIENSFMPADYSSEGIVEALCPEVKGKTVDLARSAYGAKLLIDGLE
KCGATVYETHVYTLSIPEGAAQKELIERTLSGEVDAFAFTSSMMVRGFMKHAENLGASEAVKEILSRAVVGAIGTPTGNT
LKKHGVNANVIPDEFTFEALIKAMKKEF

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29542; Mature: 29411

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGERNMAEEKIPVLAIMRPESYREKSEAIARDYGFEPLCVPMIKLEGIKDDGFEPFIQR
CCCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEHHHEECCCCCCCHHHHHHH
VIDGTSDYVVFTSANGITFTLDKLTEDEKKNFITALKKRKVIAIGPNTEKELVRIGIENS
HHCCCCCEEEEEECCCCEEEHHHHCCHHHHHHHHHHHHCCEEEECCCCHHHHHEECCCCC
FMPADYSSEGIVEALCPEVKGKTVDLARSAYGAKLLIDGLEKCGATVYETHVYTLSIPEG
CCCCCCCCCCHHHHHCHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEEEECCCC
AAQKELIERTLSGEVDAFAFTSSMMVRGFMKHAENLGASEAVKEILSRAVVGAIGTPTGN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
TLKKHGVNANVIPDEFTFEALIKAMKKEF
HHHHCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGERNMAEEKIPVLAIMRPESYREKSEAIARDYGFEPLCVPMIKLEGIKDDGFEPFIQR
CCCCCCHHHCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEHHHEECCCCCCCHHHHHHH
VIDGTSDYVVFTSANGITFTLDKLTEDEKKNFITALKKRKVIAIGPNTEKELVRIGIENS
HHCCCCCEEEEEECCCCEEEHHHHCCHHHHHHHHHHHHCCEEEECCCCHHHHHEECCCCC
FMPADYSSEGIVEALCPEVKGKTVDLARSAYGAKLLIDGLEKCGATVYETHVYTLSIPEG
CCCCCCCCCCHHHHHCHHHCCCCHHHHHHHCCHHHHHHHHHHCCCEEEEEEEEEEECCCC
AAQKELIERTLSGEVDAFAFTSSMMVRGFMKHAENLGASEAVKEILSRAVVGAIGTPTGN
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
TLKKHGVNANVIPDEFTFEALIKAMKKEF
HHHHCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]