Click here to switch to the map view.

The map label for this gene is cysG [H]

Identifier: 21226409

GI number: 21226409

Start: 410613

End: 411380

Strand: Direct

Name: cysG [H]

Synonym: MM_0307

Alternate gene names: 21226409

Gene position: 410613-411380 (Clockwise)

Preceding gene: 21226407

Following gene: 21226410

Centisome position: 10.02

GC content: 49.48

Gene sequence:

>768_bases
ATGTCAGGAAATTACGGAAAAGTCTATCTTGTGGGTTCCGGTCCAGGTGACCCTGAGCTTCTTACCCTGAAAGCCCGCCG
GCTGATCGACAGTGCTGAAGTCATAATCTATGACCAGCTTCCGGGAAAAACAATTTTAAGCTCAATGCCGGAAACCGCAG
AAAAAATTGATGTAGGAAAATATGCGGGCAACCATACCATGACTCAGTCTGAGATCAACGATGTACTTGTGCGGAAAGCA
AAAGAGGGTAAAATGGTAGTCCGCCTGAAAGGGGGAGACCCTTACGTTTTCGGAAGAGGAGGAGAGGAAGCCGAGGTACT
TGTAGCAGAAGGTATAGAATTTGAAGTCGTGCCAGGGATCACTTCCGCAATCGCAGTGCCTGCCTACGCCGGAATTCCTG
TAACCCACAGGGAAAGCACTTCAATGGTTACTTTCATAACCGGCCACGAAGACCCAACAAAGGAAGAAAGCGGACTCGAC
TGGAAGACTCTGGCAAAGTTTAACGGAACCATTGTAATCTTCATGGGCGTAAAGATGCTCAGGCGAAATGCAGAAGAGCT
CATAAAGCACGGCAAAGACCCTGAAACCCCTGTGGCAGTCATTGAAAGGGGAACCCGGCCTGACCAGAGGGTAACCGTGG
GCACCCTTGAAAATATCGCCGACCTGGCGGAAGAGAGAAAAGTAAAAGCCCCTGCCATCACAGTCGTAGGAGAGGTAGTT
AACCTGCACGAAATTCTAGGGGAACAGCTTACAGGGGCTGAGTTTTAA

Upstream 100 bases:

>100_bases
TCGGGTACGAATAATCTCCCTGGGTGTATATGAAGAGAATTATTCATCAAAGAAGAATCCATCACCAATTATAAATAAAG
AAAAAAGGAACCGTTGTTAC

Downstream 100 bases:

>100_bases
CTTGCTGAAGTGACAGGAGAAAGAAATATGGCAGAAGAGAAAATTCCCGTGCTTGCGATCATGAGGCCGGAAAGTTACCG
CGAAAAATCCGAAGCTATTG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIIYDQLPGKTILSSMPETAEKIDVGKYAGNHTMTQSEINDVLVRKA
KEGKMVVRLKGGDPYVFGRGGEEAEVLVAEGIEFEVVPGITSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLD
WKTLAKFNGTIVIFMGVKMLRRNAEELIKHGKDPETPVAVIERGTRPDQRVTVGTLENIADLAEERKVKAPAITVVGEVV
NLHEILGEQLTGAEF

Sequences:

>Translated_255_residues
MSGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIIYDQLPGKTILSSMPETAEKIDVGKYAGNHTMTQSEINDVLVRKA
KEGKMVVRLKGGDPYVFGRGGEEAEVLVAEGIEFEVVPGITSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLD
WKTLAKFNGTIVIFMGVKMLRRNAEELIKHGKDPETPVAVIERGTRPDQRVTVGTLENIADLAEERKVKAPAITVVGEVV
NLHEILGEQLTGAEF
>Mature_254_residues
SGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIIYDQLPGKTILSSMPETAEKIDVGKYAGNHTMTQSEINDVLVRKAK
EGKMVVRLKGGDPYVFGRGGEEAEVLVAEGIEFEVVPGITSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLDW
KTLAKFNGTIVIFMGVKMLRRNAEELIKHGKDPETPVAVIERGTRPDQRVTVGTLENIADLAEERKVKAPAITVVGEVVN
LHEILGEQLTGAEF

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=241, Percent_Identity=46.8879668049792, Blast_Score=218, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322922, Length=238, Percent_Identity=37.8151260504202, Blast_Score=141, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27596; Mature: 27465

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIIYDQLPGKTILSSMPETAEKIDVGK
CCCCCEEEEEEECCCCCCCEEEEEHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHHCCCC
YAGNHTMTQSEINDVLVRKAKEGKMVVRLKGGDPYVFGRGGEEAEVLVAEGIEFEVVPGI
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEECCCEEEECCCC
TSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLDWKTLAKFNGTIVIFMGVKML
HHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEECHHHH
RRNAEELIKHGKDPETPVAVIERGTRPDQRVTVGTLENIADLAEERKVKAPAITVVGEVV
HCCHHHHHHCCCCCCCCCHHEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NLHEILGEQLTGAEF
HHHHHHHHHCCCCCC
>Mature Secondary Structure 
SGNYGKVYLVGSGPGDPELLTLKARRLIDSAEVIIYDQLPGKTILSSMPETAEKIDVGK
CCCCEEEEEEECCCCCCCEEEEEHHHHCCCCCEEEEECCCCHHHHHCCCHHHHHHCCCC
YAGNHTMTQSEINDVLVRKAKEGKMVVRLKGGDPYVFGRGGEEAEVLVAEGIEFEVVPGI
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCEEEEECCCEEEECCCC
TSAIAVPAYAGIPVTHRESTSMVTFITGHEDPTKEESGLDWKTLAKFNGTIVIFMGVKML
HHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEECHHHH
RRNAEELIKHGKDPETPVAVIERGTRPDQRVTVGTLENIADLAEERKVKAPAITVVGEVV
HCCHHHHHHCCCCCCCCCHHEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NLHEILGEQLTGAEF
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA