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The map label for this gene is rnz

Identifier: 21226408

GI number: 21226408

Start: 409242

End: 410159

Strand: Reverse

Name: rnz

Synonym: MM_0306

Alternate gene names: 21226408

Gene position: 410159-409242 (Counterclockwise)

Preceding gene: 21226412

Following gene: 21226405

Centisome position: 10.01

GC content: 49.35

Gene sequence:

>918_bases
ATGCTTCGCATTATTTTTCTCGGCACTGGAGGCTCTCTCCCGACCCGCAACAGAAACCCGTCTGCAGTGATTGTCAACCT
GAAAGGGGAGCTCCTCCTCTTTGACTGTGGTGAAGGAACCCAGCAGCAGATGATGAGGGCAAAGACAGGAATGATGAGCC
TGTCTTCTATTTTTGTCAGCCATTTTCATGCTGACCATTTCCTCGGGATTCCCGGCCTTATTCAAACAATGTCTTTCCTC
GGCAGGAAAGAGCCGCTGACGATTTACGGACCTGAAGGAACAAAGGAGTTCACCGAGGTTTTTAAGGTCCTTGGATATTG
CAACCTTAAATACGAAGTCAGAGGTGTCGAACTGAGTCCTGGGGACATTGTGGAAGGAAAAAATTATGTGGTCCGTGCTC
TGAAGACCGAACACAGCACTCCGAGCCTCGGGTATTCTCTTATTGAAAACCCCAGGCCCGGACGTTTCAACAGGGAAAAG
GCAGTAGAGCTTGGAGTTCTTCCTGGACCTCTTTTTGCGAAACTGCAGAAAGGCAACCCTGTAGAAGTAAATGGAAAGCT
TGTAAAGCCCGAAGAAGTTGTGGGAGCTCCAAGGCCCGGAAGGACGGTTGTATACTCAGGAGACACCCGGCCCTGTGAAG
CAGTGCTCGAAGCCAGCAGGGATGCTGATGTCCTGATTCATGATGGCAGTTTTGCAGACGAGATGGCAGGCTGGGCGGAA
GAATCCATGCATTCGACAGCAGGCGAGGTTGCATCTCTCGCTAAAGAAGCCGGAGTCAGGCAACTTGTCCTTACCCATAT
CAGTTCACGTTATACTGATGATGTGGGACCTATCCTGAATGATTCGAGAAAAGTATTTGAAAATGTTATTGTAGCCGAAG
ACCTGATGGAACTTGAAGTCCCTTACAGACCTGATTGA

Upstream 100 bases:

>100_bases
TTATGAGTCCTTTATTACCAGCCAGTTTATCACAAATGGCCGTTTTATCATAAATGAATGGTCATCACATCAGTATTCAG
CATAAATCAGTGAGTTCATC

Downstream 100 bases:

>100_bases
GTCCACTGCTGAGGATATTAATAATTTAATTTTTAGAAACAAAGATTGAGATTCAGGTTACAGGATTTAAAAAGTAGATT
CCAGGTTTAAAAAATGGGTT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLRIIFLGTGGSLPTRNRNPSAVIVNLKGELLLFDCGEGTQQQMMRAKTGMMSLSSIFVSHFHADHFLGIPGLIQTMSFL
GRKEPLTIYGPEGTKEFTEVFKVLGYCNLKYEVRGVELSPGDIVEGKNYVVRALKTEHSTPSLGYSLIENPRPGRFNREK
AVELGVLPGPLFAKLQKGNPVEVNGKLVKPEEVVGAPRPGRTVVYSGDTRPCEAVLEASRDADVLIHDGSFADEMAGWAE
ESMHSTAGEVASLAKEAGVRQLVLTHISSRYTDDVGPILNDSRKVFENVIVAEDLMELEVPYRPD

Sequences:

>Translated_305_residues
MLRIIFLGTGGSLPTRNRNPSAVIVNLKGELLLFDCGEGTQQQMMRAKTGMMSLSSIFVSHFHADHFLGIPGLIQTMSFL
GRKEPLTIYGPEGTKEFTEVFKVLGYCNLKYEVRGVELSPGDIVEGKNYVVRALKTEHSTPSLGYSLIENPRPGRFNREK
AVELGVLPGPLFAKLQKGNPVEVNGKLVKPEEVVGAPRPGRTVVYSGDTRPCEAVLEASRDADVLIHDGSFADEMAGWAE
ESMHSTAGEVASLAKEAGVRQLVLTHISSRYTDDVGPILNDSRKVFENVIVAEDLMELEVPYRPD
>Mature_305_residues
MLRIIFLGTGGSLPTRNRNPSAVIVNLKGELLLFDCGEGTQQQMMRAKTGMMSLSSIFVSHFHADHFLGIPGLIQTMSFL
GRKEPLTIYGPEGTKEFTEVFKVLGYCNLKYEVRGVELSPGDIVEGKNYVVRALKTEHSTPSLGYSLIENPRPGRFNREK
AVELGVLPGPLFAKLQKGNPVEVNGKLVKPEEVVGAPRPGRTVVYSGDTRPCEAVLEASRDADVLIHDGSFADEMAGWAE
ESMHSTAGEVASLAKEAGVRQLVLTHISSRYTDDVGPILNDSRKVFENVIVAEDLMELEVPYRPD

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=363, Percent_Identity=31.6804407713499, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI260166619, Length=296, Percent_Identity=25.6756756756757, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI260166622, Length=296, Percent_Identity=25.6756756756757, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI145553959, Length=296, Percent_Identity=25.6756756756757, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082078, Length=306, Percent_Identity=37.5816993464052, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71985814, Length=323, Percent_Identity=25.077399380805, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71985808, Length=323, Percent_Identity=25.077399380805, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24652403, Length=314, Percent_Identity=28.0254777070064, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_METMA (Q8Q032)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632330.1
- ProteinModelPortal:   Q8Q032
- SMR:   Q8Q032
- GeneID:   1478648
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0306
- NMPDR:   fig|192952.1.peg.306
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   PRK00055
- BioCyc:   MMAZ192952:MM0306-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 33415; Mature: 33415

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIIFLGTGGSLPTRNRNPSAVIVNLKGELLLFDCGEGTQQQMMRAKTGMMSLSSIFVS
CEEEEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
HFHADHFLGIPGLIQTMSFLGRKEPLTIYGPEGTKEFTEVFKVLGYCNLKYEVRGVELSP
HHCCCHHCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEECC
GDIVEGKNYVVRALKTEHSTPSLGYSLIENPRPGRFNREKAVELGVLPGPLFAKLQKGNP
CCEECCCHHEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHEEECCCCCHHHHHCCCCCC
VEVNGKLVKPEEVVGAPRPGRTVVYSGDTRPCEAVLEASRDADVLIHDGSFADEMAGWAE
EEECCEEECHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
ESMHSTAGEVASLAKEAGVRQLVLTHISSRYTDDVGPILNDSRKVFENVIVAEDLMELEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
PYRPD
CCCCC
>Mature Secondary Structure
MLRIIFLGTGGSLPTRNRNPSAVIVNLKGELLLFDCGEGTQQQMMRAKTGMMSLSSIFVS
CEEEEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
HFHADHFLGIPGLIQTMSFLGRKEPLTIYGPEGTKEFTEVFKVLGYCNLKYEVRGVELSP
HHCCCHHCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEECC
GDIVEGKNYVVRALKTEHSTPSLGYSLIENPRPGRFNREKAVELGVLPGPLFAKLQKGNP
CCEECCCHHEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHEEECCCCCHHHHHCCCCCC
VEVNGKLVKPEEVVGAPRPGRTVVYSGDTRPCEAVLEASRDADVLIHDGSFADEMAGWAE
EEECCEEECHHHHHCCCCCCCEEEECCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHH
ESMHSTAGEVASLAKEAGVRQLVLTHISSRYTDDVGPILNDSRKVFENVIVAEDLMELEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHCCC
PYRPD
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824