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The map label for this gene is CobQ

Identifier: 20806888

GI number: 20806888

Start: 400510

End: 402036

Strand: Direct

Name: CobQ

Synonym: TTE0376

Alternate gene names: 20806888

Gene position: 400510-402036 (Clockwise)

Preceding gene: 20806887

Following gene: 20806889

Centisome position: 14.89

GC content: 39.03

Gene sequence:

>1527_bases
ATGGCGTTGAAACTTATGATACAGGGTACGGCCTCTTCAGTGGGTAAAAGCCTTATTGTCACAGCTTTGTGCAGGATATT
CAAACAGGATGGACTTAAAGTTGCGCCTTTCAAATCTCAAAATATGGCTTTGAACTCCTATATTACAGAAGAAGGGCTGG
AAATAGGGAGAGCTCAGGCTGTTCAGGCAGAAGCGGCAGGAATAAAGCCTTCCTATCACATGAATCCAATACTTCTAAAG
CCTAGCTCTGACAAGAAAAGCCAGGTTGTCTTAAGAGGAAGAGTCTATGAAAACATGAGTGCAGAAGAATACTTTAAGTT
CAGACCCAAGCTTTTGGAACTCATAAAAGAGGACTTTGATTTTCTTGCCAAAAGAAATGACGTGGTGGTCATAGAAGGAG
CAGGAAGTCCTGCAGAGATAAACTTAAAAGAGAAGGATATTGTCAACATGGGCTTGGCAGAGCTGGTAAATGCGCCAGTG
CTACTTGTTGGCGACATAGATAGAGGAGGAGTGTTTGCTTCAATTGCCGGCACAATGCTTCTTCTCGATGAAAAAGAAAG
AAATCGCGTAGAAGGAGTTATAATAAACAAATTCAGGGGAGATATAGAAATATTAAAGCCGGGGCTTAAAATGCTTGAAA
ATATAATACAAAAAGAAGTGCTAGGAGTTATACCCTATATGGATGTGCACATTGATGAAGAAGACGGGGCTACTGACAGA
TTTTATACAAAATGTGCCCAGGGAGAAGTGGATGTAGCTATAATAAACCTTCCTCACATATCCAATTTTACTGATTTTGA
CCCTCTTACAAAAGTTCCAGGTGTAAAGATAAAGTATGTGAACAAAGGAGAAAGAATAGGAGATTGCGATGTTTTGATAA
TACCGGGAACCAAAAACACGATAGGGGATTTAAAAGTTTTAAAAGACTACGGCTTAGATAAAGAAATTTTAAACTTAAGA
GAAAAAGGGAAATTCATAGTCGGAATATGTGGTGGATTTCAGATGCTTGGAAAAGTAATAAAAGACCCCTATCACATAGA
GAGCGATACAGAGGAAATGGAAGGGTTGGGACTTCTTAGTATAGAGACAGTGATTGAGCGTGAAAAAACCACCTCAGAGA
CTAAAGCGTTCTTGGGAGAAGAACTGCCGGATACTCTTTCATCTTTGAAAGGACTTTTTGTGACAGGATACGAGATACAC
ATGGGAGAAAGCTACATTTTGGGAAAAGGGAAGCACTTTTCTATTGTCGTGGAAAGGAATAAAGAAAAAGTAAAAGTACT
GGATGGAGCGGTTAGTGAAGATGGTAGAGTATTCGGGACGTATATTCACGGCATTTTTGAAAACAGCCTTTTTACGAAGG
AATTTATAAACATTGTAAGGAAAGAAAAAGGGCTTACTCCTTTAGAGGAGGTCATCAATTACAGAGAATTTAGAGAAAAA
GAATATGACAGGCTTGCAAATATTGTGAGAAACTCCCTTGACATGGAAAGGATATACCAGATAATGGAGAGGTATAGAGA
CAAATGA

Upstream 100 bases:

>100_bases
AAAAACTGTCTCGCAAGTTTTGTTCACATAAACTTATACACATACAAAGAAGGAGTGAAGAGATTTTTAGACAGGTGTTC
ATCTTTTGGGAGGAAATAGT

Downstream 100 bases:

>100_bases
AAGTTTTTCTGGCATATATTCTCGATTTGATTTTAGGAGACCCTGAGGGTTATCCTCATCCTGTAAGGCTGATAGGATCT
CTTATATCAAAAGAAGAAAG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MALKLMIQGTASSVGKSLIVTALCRIFKQDGLKVAPFKSQNMALNSYITEEGLEIGRAQAVQAEAAGIKPSYHMNPILLK
PSSDKKSQVVLRGRVYENMSAEEYFKFRPKLLELIKEDFDFLAKRNDVVVIEGAGSPAEINLKEKDIVNMGLAELVNAPV
LLVGDIDRGGVFASIAGTMLLLDEKERNRVEGVIINKFRGDIEILKPGLKMLENIIQKEVLGVIPYMDVHIDEEDGATDR
FYTKCAQGEVDVAIINLPHISNFTDFDPLTKVPGVKIKYVNKGERIGDCDVLIIPGTKNTIGDLKVLKDYGLDKEILNLR
EKGKFIVGICGGFQMLGKVIKDPYHIESDTEEMEGLGLLSIETVIEREKTTSETKAFLGEELPDTLSSLKGLFVTGYEIH
MGESYILGKGKHFSIVVERNKEKVKVLDGAVSEDGRVFGTYIHGIFENSLFTKEFINIVRKEKGLTPLEEVINYREFREK
EYDRLANIVRNSLDMERIYQIMERYRDK

Sequences:

>Translated_508_residues
MALKLMIQGTASSVGKSLIVTALCRIFKQDGLKVAPFKSQNMALNSYITEEGLEIGRAQAVQAEAAGIKPSYHMNPILLK
PSSDKKSQVVLRGRVYENMSAEEYFKFRPKLLELIKEDFDFLAKRNDVVVIEGAGSPAEINLKEKDIVNMGLAELVNAPV
LLVGDIDRGGVFASIAGTMLLLDEKERNRVEGVIINKFRGDIEILKPGLKMLENIIQKEVLGVIPYMDVHIDEEDGATDR
FYTKCAQGEVDVAIINLPHISNFTDFDPLTKVPGVKIKYVNKGERIGDCDVLIIPGTKNTIGDLKVLKDYGLDKEILNLR
EKGKFIVGICGGFQMLGKVIKDPYHIESDTEEMEGLGLLSIETVIEREKTTSETKAFLGEELPDTLSSLKGLFVTGYEIH
MGESYILGKGKHFSIVVERNKEKVKVLDGAVSEDGRVFGTYIHGIFENSLFTKEFINIVRKEKGLTPLEEVINYREFREK
EYDRLANIVRNSLDMERIYQIMERYRDK
>Mature_507_residues
ALKLMIQGTASSVGKSLIVTALCRIFKQDGLKVAPFKSQNMALNSYITEEGLEIGRAQAVQAEAAGIKPSYHMNPILLKP
SSDKKSQVVLRGRVYENMSAEEYFKFRPKLLELIKEDFDFLAKRNDVVVIEGAGSPAEINLKEKDIVNMGLAELVNAPVL
LVGDIDRGGVFASIAGTMLLLDEKERNRVEGVIINKFRGDIEILKPGLKMLENIIQKEVLGVIPYMDVHIDEEDGATDRF
YTKCAQGEVDVAIINLPHISNFTDFDPLTKVPGVKIKYVNKGERIGDCDVLIIPGTKNTIGDLKVLKDYGLDKEILNLRE
KGKFIVGICGGFQMLGKVIKDPYHIESDTEEMEGLGLLSIETVIEREKTTSETKAFLGEELPDTLSSLKGLFVTGYEIHM
GESYILGKGKHFSIVVERNKEKVKVLDGAVSEDGRVFGTYIHGIFENSLFTKEFINIVRKEKGLTPLEEVINYREFREKE
YDRLANIVRNSLDMERIYQIMERYRDK

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_THETN (Q8RCP3)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_622059.1
- ProteinModelPortal:   Q8RCP3
- GeneID:   997314
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0376
- NMPDR:   fig|273068.3.peg.340
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   TTEN273068:TTE0376-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 57011; Mature: 56880

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 330-330 ACT_SITE 443-443

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKLMIQGTASSVGKSLIVTALCRIFKQDGLKVAPFKSQNMALNSYITEEGLEIGRAQA
CEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHCHHHH
VQAEAAGIKPSYHMNPILLKPSSDKKSQVVLRGRVYENMSAEEYFKFRPKLLELIKEDFD
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLAKRNDVVVIEGAGSPAEINLKEKDIVNMGLAELVNAPVLLVGDIDRGGVFASIAGTML
HHHCCCCEEEEECCCCCCEECCCHHHHHHCCHHHHCCCCEEEEECCCCCCEEHHHHCEEE
LLDEKERNRVEGVIINKFRGDIEILKPGLKMLENIIQKEVLGVIPYMDVHIDEEDGATDR
EEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
FYTKCAQGEVDVAIINLPHISNFTDFDPLTKVPGVKIKYVNKGERIGDCDVLIIPGTKNT
HHHHHCCCCEEEEEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCEEEECCCCCC
IGDLKVLKDYGLDKEILNLREKGKFIVGICGGFQMLGKVIKDPYHIESDTEEMEGLGLLS
HHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCEEH
IETVIEREKTTSETKAFLGEELPDTLSSLKGLFVTGYEIHMGESYILGKGKHFSIVVERN
HHHHHHHHHCHHHHHHHHCCCCHHHHHHCCCEEEEEEEEECCCEEEEECCCEEEEEEECC
KEKVKVLDGAVSEDGRVFGTYIHGIFENSLFTKEFINIVRKEKGLTPLEEVINYREFREK
CCEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EYDRLANIVRNSLDMERIYQIMERYRDK
HHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALKLMIQGTASSVGKSLIVTALCRIFKQDGLKVAPFKSQNMALNSYITEEGLEIGRAQA
EEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHCHHHH
VQAEAAGIKPSYHMNPILLKPSSDKKSQVVLRGRVYENMSAEEYFKFRPKLLELIKEDFD
HHHHHCCCCCCCCCCEEEECCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHH
FLAKRNDVVVIEGAGSPAEINLKEKDIVNMGLAELVNAPVLLVGDIDRGGVFASIAGTML
HHHCCCCEEEEECCCCCCEECCCHHHHHHCCHHHHCCCCEEEEECCCCCCEEHHHHCEEE
LLDEKERNRVEGVIINKFRGDIEILKPGLKMLENIIQKEVLGVIPYMDVHIDEEDGATDR
EEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
FYTKCAQGEVDVAIINLPHISNFTDFDPLTKVPGVKIKYVNKGERIGDCDVLIIPGTKNT
HHHHHCCCCEEEEEEECCCCCCCCCCCCHHCCCCCEEEEECCCCCCCCCCEEEECCCCCC
IGDLKVLKDYGLDKEILNLREKGKFIVGICGGFQMLGKVIKDPYHIESDTEEMEGLGLLS
HHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCEEH
IETVIEREKTTSETKAFLGEELPDTLSSLKGLFVTGYEIHMGESYILGKGKHFSIVVERN
HHHHHHHHHCHHHHHHHHCCCCHHHHHHCCCEEEEEEEEECCCEEEEECCCEEEEEEECC
KEKVKVLDGAVSEDGRVFGTYIHGIFENSLFTKEFINIVRKEKGLTPLEEVINYREFREK
CCEEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EYDRLANIVRNSLDMERIYQIMERYRDK
HHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336