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The map label for this gene is ygbD [C]

Identifier: 20094317

GI number: 20094317

Start: 831689

End: 833029

Strand: Direct

Name: ygbD [C]

Synonym: MK0881

Alternate gene names: 20094317

Gene position: 831689-833029 (Clockwise)

Preceding gene: 20094316

Following gene: 20094318

Centisome position: 49.07

GC content: 60.78

Gene sequence:

>1341_bases
TTGCGCGTTGTGGTGGTAGGAGGCGGAGCCGCCGGCGTCGTAGCCGCTCGGACTGCCCGGGAACACGGCGCCGACGTGGT
TCTAATCTCGGCGGATGAGCATATCGCGTACTCCCCCTGCGCCATCCCGTTCGTAATCTCAGGGGAGATAGAACGACCGG
AAGATATCCTGATGCGCGATCCCACCCACTACGAGCGCCTCGGGATCGACGTCAGGCTGGGCGTGAGGGTGGAGGAAGTC
GATCCCGAAGAGAAGGTCGTGACCACCGAAGACGGTGACACCGTCGAATACGACTCGATGGTTCTCGCTACCGGTGGAGA
GCCTCTAGTTCCCCCGATCGAGGGTTCCGAACTGGACGGCGTCTTCACCGTTCGGCGGTTTTCGGATATCGAGCCTCTAC
TACGAGCCGTTCAGGAGTCGGAGCGAGCTGTGATAGTGGGAGCAGGACCCATCGGTGTAGAGATGGCGTACGCCCTTCAC
GAACGCGGGTTAGAGGTCACGCTGGTCGAAATGCTCGATAGGGTTCTTCCGCAGTTCCTCGACGATGATGTCGCCGCGAT
AGTGCAAGAGCGGATGGAAAAGGAGGGCGTCAGAGTACTTCTCGGCTCGCCTGTGGAGGCTATAGAAGGCGATGATAGAG
TGGAGGCCGTGGTGGTAAACGGTGAAGAGATAGAGGCCGACCTCGTCGTGATGGCGGCCGGTGTGAGGCCGGTAACGGAC
CTCTTTGAGAGCATAGGGGCTTCGGTCCTACCCTTTGGGGTTGAAGTCGATCCCGCCCTTCGAGTCAAGCGCGAGGACGG
CGGTGTCTTCGACGATATATACGCGGCCGGGGATTGTGTGGCTGATTGGTGTCCCATCACGGGTGAGCGAGTTCCGAGCC
AGCTCGGCACGGTCGCCGTTCGACAGGGCAAGATCGCCGGGAAAAACGCCGCTGGAGGTCCCAGGGCGACTTGGATGGGT
ACCCTCAACACCGCAGTGATCCGCGTGTTCGATCTGGAGGCGGCGGGTGCGGGATTGACACAGACCAGGGCCGAAGAATT
AGGGTTGGAGGTGGTTTCGGCCACCGTCGAGACGACCACCAGGGCCAGGTATTATCCGGGTGGCGAGCCTATTGCGGTCA
AGTTAATAGCTGATGCGGACACGCACCGTATCGTCGGAGTTCAATCCGTTGGAGGGGAACGGGTGAGGGAGCGCGTCGAC
GGTGTCGCTTTGGCCATCCGGCTGGCGGCTAAAGTAGAGGACCTCCTGAGCTGGGATTACTCCTACTCGCCTCCGGTCGC
TCGGGTTATAGAACCCATATACGAGGCCGCCGAGCTCCTTAGGGAGGAGCTTCACTCATGA

Upstream 100 bases:

>100_bases
GTACCTCAGAGGAGTGTGGAGGATCAGGAAGGACTTGAAGCAGCGTGGGCTCCTGTAAACGTTTTCACATACCTGCTCCG
GATGGCTCGAGGGCAGAAGA

Downstream 100 bases:

>100_bases
AGCGCTTCCTCAGAGACCTTTCCGCCGCCACAGCATCACTGACGGCCTTGGTCCTCATGGAATCGTTCACGGGGATTACG
CTCGAATCCCTTAAGCATCG

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MRVVVVGGGAAGVVAARTAREHGADVVLISADEHIAYSPCAIPFVISGEIERPEDILMRDPTHYERLGIDVRLGVRVEEV
DPEEKVVTTEDGDTVEYDSMVLATGGEPLVPPIEGSELDGVFTVRRFSDIEPLLRAVQESERAVIVGAGPIGVEMAYALH
ERGLEVTLVEMLDRVLPQFLDDDVAAIVQERMEKEGVRVLLGSPVEAIEGDDRVEAVVVNGEEIEADLVVMAAGVRPVTD
LFESIGASVLPFGVEVDPALRVKREDGGVFDDIYAAGDCVADWCPITGERVPSQLGTVAVRQGKIAGKNAAGGPRATWMG
TLNTAVIRVFDLEAAGAGLTQTRAEELGLEVVSATVETTTRARYYPGGEPIAVKLIADADTHRIVGVQSVGGERVRERVD
GVALAIRLAAKVEDLLSWDYSYSPPVARVIEPIYEAAELLREELHS

Sequences:

>Translated_446_residues
MRVVVVGGGAAGVVAARTAREHGADVVLISADEHIAYSPCAIPFVISGEIERPEDILMRDPTHYERLGIDVRLGVRVEEV
DPEEKVVTTEDGDTVEYDSMVLATGGEPLVPPIEGSELDGVFTVRRFSDIEPLLRAVQESERAVIVGAGPIGVEMAYALH
ERGLEVTLVEMLDRVLPQFLDDDVAAIVQERMEKEGVRVLLGSPVEAIEGDDRVEAVVVNGEEIEADLVVMAAGVRPVTD
LFESIGASVLPFGVEVDPALRVKREDGGVFDDIYAAGDCVADWCPITGERVPSQLGTVAVRQGKIAGKNAAGGPRATWMG
TLNTAVIRVFDLEAAGAGLTQTRAEELGLEVVSATVETTTRARYYPGGEPIAVKLIADADTHRIVGVQSVGGERVRERVD
GVALAIRLAAKVEDLLSWDYSYSPPVARVIEPIYEAAELLREELHS
>Mature_446_residues
MRVVVVGGGAAGVVAARTAREHGADVVLISADEHIAYSPCAIPFVISGEIERPEDILMRDPTHYERLGIDVRLGVRVEEV
DPEEKVVTTEDGDTVEYDSMVLATGGEPLVPPIEGSELDGVFTVRRFSDIEPLLRAVQESERAVIVGAGPIGVEMAYALH
ERGLEVTLVEMLDRVLPQFLDDDVAAIVQERMEKEGVRVLLGSPVEAIEGDDRVEAVVVNGEEIEADLVVMAAGVRPVTD
LFESIGASVLPFGVEVDPALRVKREDGGVFDDIYAAGDCVADWCPITGERVPSQLGTVAVRQGKIAGKNAAGGPRATWMG
TLNTAVIRVFDLEAAGAGLTQTRAEELGLEVVSATVETTTRARYYPGGEPIAVKLIADADTHRIVGVQSVGGERVRERVD
GVALAIRLAAKVEDLLSWDYSYSPPVARVIEPIYEAAELLREELHS

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=314, Percent_Identity=28.0254777070064, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226437568, Length=314, Percent_Identity=28.0254777070064, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI65787454, Length=314, Percent_Identity=28.0254777070064, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI22202629, Length=281, Percent_Identity=25.9786476868327, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4757732, Length=281, Percent_Identity=25.9786476868327, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789065, Length=294, Percent_Identity=29.5918367346939, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1789765, Length=263, Percent_Identity=29.6577946768061, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788892, Length=237, Percent_Identity=24.8945147679325, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786307, Length=341, Percent_Identity=27.5659824046921, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082354, Length=340, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787352, Length=323, Percent_Identity=28.7925696594427, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=379, Percent_Identity=26.9129287598945, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32565766, Length=485, Percent_Identity=22.680412371134, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24585130, Length=319, Percent_Identity=26.6457680250784, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24639257, Length=328, Percent_Identity=28.6585365853659, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281359715, Length=329, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281359713, Length=329, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24639250, Length=329, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18543267, Length=329, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24639252, Length=329, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573993, Length=267, Percent_Identity=29.2134831460674, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581020, Length=267, Percent_Identity=29.2134831460674, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358499, Length=376, Percent_Identity=27.3936170212766, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47817; Mature: 47817

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVVVGGGAAGVVAARTAREHGADVVLISADEHIAYSPCAIPFVISGEIERPEDILMRD
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEEECCCCCCHHHHCCC
PTHYERLGIDVRLGVRVEEVDPEEKVVTTEDGDTVEYDSMVLATGGEPLVPPIEGSELDG
CCHHHHCCCEEEECEEEECCCCCCCEEEECCCCEEEECCEEEECCCCCCCCCCCCCCCCC
VFTVRRFSDIEPLLRAVQESERAVIVGAGPIGVEMAYALHERGLEVTLVEMLDRVLPQFL
EEEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
DDDVAAIVQERMEKEGVRVLLGSPVEAIEGDDRVEAVVVNGEEIEADLVVMAAGVRPVTD
CCHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCHHHH
LFESIGASVLPFGVEVDPALRVKREDGGVFDDIYAAGDCVADWCPITGERVPSQLGTVAV
HHHHCCCCEECCCCEECHHEEEEECCCCCHHHHHHCCCHHHCCCCCCCCCCHHHHHHEEE
RQGKIAGKNAAGGPRATWMGTLNTAVIRVFDLEAAGAGLTQTRAEELGLEVVSATVETTT
ECCCCCCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHH
RARYYPGGEPIAVKLIADADTHRIVGVQSVGGERVRERVDGVALAIRLAAKVEDLLSWDY
CEEECCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SYSPPVARVIEPIYEAAELLREELHS
CCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVVVVGGGAAGVVAARTAREHGADVVLISADEHIAYSPCAIPFVISGEIERPEDILMRD
CEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEEECCCCCCHHHHCCC
PTHYERLGIDVRLGVRVEEVDPEEKVVTTEDGDTVEYDSMVLATGGEPLVPPIEGSELDG
CCHHHHCCCEEEECEEEECCCCCCCEEEECCCCEEEECCEEEECCCCCCCCCCCCCCCCC
VFTVRRFSDIEPLLRAVQESERAVIVGAGPIGVEMAYALHERGLEVTLVEMLDRVLPQFL
EEEEHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHH
DDDVAAIVQERMEKEGVRVLLGSPVEAIEGDDRVEAVVVNGEEIEADLVVMAAGVRPVTD
CCHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCEEEEEECCCCCCEEEEEEECCCCHHHH
LFESIGASVLPFGVEVDPALRVKREDGGVFDDIYAAGDCVADWCPITGERVPSQLGTVAV
HHHHCCCCEECCCCEECHHEEEEECCCCCHHHHHHCCCHHHCCCCCCCCCCHHHHHHEEE
RQGKIAGKNAAGGPRATWMGTLNTAVIRVFDLEAAGAGLTQTRAEELGLEVVSATVETTT
ECCCCCCCCCCCCCCEEEEECCCEEEEEEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHH
RARYYPGGEPIAVKLIADADTHRIVGVQSVGGERVRERVDGVALAIRLAAKVEDLLSWDY
CEEECCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SYSPPVARVIEPIYEAAELLREELHS
CCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]