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The map label for this gene is Ftr_2

Identifier: 20094252

GI number: 20094252

Start: 776227

End: 777129

Strand: Direct

Name: Ftr_2

Synonym: MK0816

Alternate gene names: NA

Gene position: 776227-777129 (Clockwise)

Preceding gene: 20094251

Following gene: 20094253

Centisome position: 45.8

GC content: 62.24

Gene sequence:

>903_bases
TTGGTGGAGATCAACGGAGTACCTGTAGAGGACACGTTCTGTGAGGCTTTCAAAGGCTTGTACGCACGGTTCATCGTGAC
GGCTGCCGACGAGCGTCCCTTGCGTGAGGCTGCTGAGAACGTCGCCGCTCTGCCGGCTACCGTCTTCGGCGAATCTGAGG
CAGGCGTGGAACGCTGGTTGGACCCGGAGGAGACCCCGGACGGTCGCCCGGGGTTCGTCGCTCAGATGTGGGTGGAGTAC
GGTGATGACGCCGTGAAGAAACTGGAGCACGAGCTCGGGAAGCGCATACGTCAGGGTGTGCTGGTACGACCGACCACCAG
GGTATTCGACGCTTGCGAGGATCCGGACGGCTACATCGACACGGAACGCCCCATCGGCCGTTGCGCCGACGGGTACGAAT
ACACCGACGTACGTTTCGACCGGGAGATGGTCCACGTTCCGATCATGATGGGCGAGTTCCTGATCGAGCGTCGGCTGGGG
TACGCGGAAGGTGTCGCAGGGGGCTTAGTATGGCTGTTCTGCGAAGACGTCGATGCCGCGCTCGAAGCCGGTTACCGGGC
CGTTGAGGCCCTGCGAGACGTAGAAGGCGTCATCACTCCCTTCAACGTCTGTGCCGCCGGTTCGAAGCCCGAAACTATCT
ACCCGGACATCGGTCCGACGACCAACCACCCATACTGTCCGACCCTCCGCGATAGGATCCTCGACTCGAAGGTCCCGGAA
GGTGTCGAGGCGATCCCCGAGATCGTGATCAACGGGGTCTCGCTCGACGTGGTGAAGCGAGCGATCGGAATCGCTATCGA
GGCCGCCACGGAGGTTGACGGCGTCGTCAAGGTGTCCGCCGGGAACTTCGGAGGTAAACTCGGCGACTACAGGATTCCGC
TGCGGGAGTGCATTCGGGAGTGA

Upstream 100 bases:

>100_bases
GCCGGGAGCGGATTCCGCCCCGATCCCTTATTGTTACACAGTCCGCAACGAACCGGGGATCCGGTTTATAGTTACTTTCA
CTCTACTCCTCGGGGGGAGT

Downstream 100 bases:

>100_bases
GGAGTGTTGGACGTAGTGGGTCTCGGCGCCCTCAACGTGGACGAGCTTCTGTACATCCCTCGAATGCCCGAACGCGACGA
TTCGGTACCTGTCGAACGGA

Product: formylmethanofuran--tetrahydromethanopterin formyltransferase

Products: methanofuran; 5-formyl-5,6,7,8-tetrahydromethanopterin

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MVEINGVPVEDTFCEAFKGLYARFIVTAADERPLREAAENVAALPATVFGESEAGVERWLDPEETPDGRPGFVAQMWVEY
GDDAVKKLEHELGKRIRQGVLVRPTTRVFDACEDPDGYIDTERPIGRCADGYEYTDVRFDREMVHVPIMMGEFLIERRLG
YAEGVAGGLVWLFCEDVDAALEAGYRAVEALRDVEGVITPFNVCAAGSKPETIYPDIGPTTNHPYCPTLRDRILDSKVPE
GVEAIPEIVINGVSLDVVKRAIGIAIEAATEVDGVVKVSAGNFGGKLGDYRIPLRECIRE

Sequences:

>Translated_300_residues
MVEINGVPVEDTFCEAFKGLYARFIVTAADERPLREAAENVAALPATVFGESEAGVERWLDPEETPDGRPGFVAQMWVEY
GDDAVKKLEHELGKRIRQGVLVRPTTRVFDACEDPDGYIDTERPIGRCADGYEYTDVRFDREMVHVPIMMGEFLIERRLG
YAEGVAGGLVWLFCEDVDAALEAGYRAVEALRDVEGVITPFNVCAAGSKPETIYPDIGPTTNHPYCPTLRDRILDSKVPE
GVEAIPEIVINGVSLDVVKRAIGIAIEAATEVDGVVKVSAGNFGGKLGDYRIPLRECIRE
>Mature_300_residues
MVEINGVPVEDTFCEAFKGLYARFIVTAADERPLREAAENVAALPATVFGESEAGVERWLDPEETPDGRPGFVAQMWVEY
GDDAVKKLEHELGKRIRQGVLVRPTTRVFDACEDPDGYIDTERPIGRCADGYEYTDVRFDREMVHVPIMMGEFLIERRLG
YAEGVAGGLVWLFCEDVDAALEAGYRAVEALRDVEGVITPFNVCAAGSKPETIYPDIGPTTNHPYCPTLRDRILDSKVPE
GVEAIPEIVINGVSLDVVKRAIGIAIEAATEVDGVVKVSAGNFGGKLGDYRIPLRECIRE

Specific function: Unknown

COG id: COG2037

COG function: function code C; Formylmethanofuran:tetrahydromethanopterin formyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FTR family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTRL_METKA (Q8TX60)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614099.1
- ProteinModelPortal:   Q8TX60
- GeneID:   1476917
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0816
- NMPDR:   fig|190192.1.peg.812
- HOGENOM:   HBG373021
- OMA:   CGDGYEW
- ProtClustDB:   PRK02114
- BioCyc:   MKAN190192:MK0816-MONOMER
- BRENDA:   2.3.1.101
- HAMAP:   MF_00579
- InterPro:   IPR002770
- InterPro:   IPR022667
- InterPro:   IPR014053
- Gene3D:   G3DSA:3.30.70.520
- PIRSF:   PIRSF006414

Pfam domain/function: PF01913 FTR; PF02741 FTR_C; SSF55112 FTR_trans

EC number: 2.3.1.101

Molecular weight: Translated: 32967; Mature: 32967

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEINGVPVEDTFCEAFKGLYARFIVTAADERPLREAAENVAALPATVFGESEAGVERWL
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHCC
DPEETPDGRPGFVAQMWVEYGDDAVKKLEHELGKRIRQGVLVRPTTRVFDACEDPDGYID
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCEECCCHHHHHHCCCCCCCCCC
TERPIGRCADGYEYTDVRFDREMVHVPIMMGEFLIERRLGYAEGVAGGLVWLFCEDVDAA
CCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCHHHH
LEAGYRAVEALRDVEGVITPFNVCAAGSKPETIYPDIGPTTNHPYCPTLRDRILDSKVPE
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCC
GVEAIPEIVINGVSLDVVKRAIGIAIEAATEVDGVVKVSAGNFGGKLGDYRIPLRECIRE
HHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure
MVEINGVPVEDTFCEAFKGLYARFIVTAADERPLREAAENVAALPATVFGESEAGVERWL
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHCCCCHHHHHHCC
DPEETPDGRPGFVAQMWVEYGDDAVKKLEHELGKRIRQGVLVRPTTRVFDACEDPDGYID
CCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCCEECCCHHHHHHCCCCCCCCCC
TERPIGRCADGYEYTDVRFDREMVHVPIMMGEFLIERRLGYAEGVAGGLVWLFCEDVDAA
CCCCHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCHHHH
LEAGYRAVEALRDVEGVITPFNVCAAGSKPETIYPDIGPTTNHPYCPTLRDRILDSKVPE
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCC
GVEAIPEIVINGVSLDVVKRAIGIAIEAATEVDGVVKVSAGNFGGKLGDYRIPLRECIRE
HHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; 5,6,7,8-tetrahydromethanopterin

Specific reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014