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The map label for this gene is MscS [H]

Identifier: 20094251

GI number: 20094251

Start: 775372

End: 776106

Strand: Direct

Name: MscS [H]

Synonym: MK0815

Alternate gene names: 20094251

Gene position: 775372-776106 (Clockwise)

Preceding gene: 20094247

Following gene: 20094252

Centisome position: 45.75

GC content: 60.54

Gene sequence:

>735_bases
GTGGAACTGCCGTCGATGAAGCTCCCGTCGGCACACGTGGAGCCGCTGAAGCTGGCCACGGCGATCGTAATAGCCTTGCT
CCTCGTGAAGATCATGGGTCGAGCGGCTCGGGCCGTTCGGGGTAAGCTCGAAGAGGAGGACTTACAGGATTTGGGGTGGT
GGGTGGAGAAGACGCTCCTGTATGGTTCTTACCTCCTGGCGTTCTCGATAGTCCTCGAGTCCCTAGGGGTGAGCCTCTGG
GCTCTCGTCACTGGATTAGGGCTGGCCGGAGCCGGTATCGCGGTAGCCGCCCGTGATCTTATTGCGAACCTACTAGCGGG
GTTGTACCTGGCACTGGAGCGCCCCTTCGAAGTGGGTGACAGAATCCGAGTCGGTGAGTACTCAGGGGAGGTGGTTGACC
TCCGAATCCGGTGCACGGTGTTGAAGTCCAGAGGTCGGAGGATAGTCATTCCCAACTCCGTTCTAGTCAACGAGACCGTG
GAGAAGCTGGACGACTCCGACGAATGCGAGTTCGAGGTCGTAGTAGAGGGATCCCCGGGTGAAATCGGGCGCCGGTTGGC
CGCGCTCGAAAAAGAGTTGGACTCCCTAAAGCTGAAGTATTACGAGATCTCGGTGGAACGTGTGGAGTCGGGCAGGACGC
TGGTCCGGGTGCGGACGGCTGGGAAGGAAGTGGATAGTGTGCATGGGGCGGTTCGACGCGCGCTCGTGAAGAGGCCTGGC
GGGACAGACCGCTGA

Upstream 100 bases:

>100_bases
TGACCTGGTCGGTGACGTCGATCACCTGAACCCTGCGTTCCGACTTGATCCTCAGCTCGGCCTGGTACACTGACAACGCC
CGCACCCCGGGGGACATCCT

Downstream 100 bases:

>100_bases
GGGATGACGATTAACCGGGAGCCGGGAGCGGATTCCGCCCCGATCCCTTATTGTTACACAGTCCGCAACGAACCGGGGAT
CCGGTTTATAGTTACTTTCA

Product: small-conductance mechanosensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MELPSMKLPSAHVEPLKLATAIVIALLLVKIMGRAARAVRGKLEEEDLQDLGWWVEKTLLYGSYLLAFSIVLESLGVSLW
ALVTGLGLAGAGIAVAARDLIANLLAGLYLALERPFEVGDRIRVGEYSGEVVDLRIRCTVLKSRGRRIVIPNSVLVNETV
EKLDDSDECEFEVVVEGSPGEIGRRLAALEKELDSLKLKYYEISVERVESGRTLVRVRTAGKEVDSVHGAVRRALVKRPG
GTDR

Sequences:

>Translated_244_residues
MELPSMKLPSAHVEPLKLATAIVIALLLVKIMGRAARAVRGKLEEEDLQDLGWWVEKTLLYGSYLLAFSIVLESLGVSLW
ALVTGLGLAGAGIAVAARDLIANLLAGLYLALERPFEVGDRIRVGEYSGEVVDLRIRCTVLKSRGRRIVIPNSVLVNETV
EKLDDSDECEFEVVVEGSPGEIGRRLAALEKELDSLKLKYYEISVERVESGRTLVRVRTAGKEVDSVHGAVRRALVKRPG
GTDR
>Mature_244_residues
MELPSMKLPSAHVEPLKLATAIVIALLLVKIMGRAARAVRGKLEEEDLQDLGWWVEKTLLYGSYLLAFSIVLESLGVSLW
ALVTGLGLAGAGIAVAARDLIANLLAGLYLALERPFEVGDRIRVGEYSGEVVDLRIRCTVLKSRGRRIVIPNSVLVNETV
EKLDDSDECEFEVVVEGSPGEIGRRLAALEKELDSLKLKYYEISVERVESGRTLVRVRTAGKEVDSVHGAVRRALVKRPG
GTDR

Specific function: May play a role in resistance to osmotic downshock [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 26715; Mature: 26715

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELPSMKLPSAHVEPLKLATAIVIALLLVKIMGRAARAVRGKLEEEDLQDLGWWVEKTLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YGSYLLAFSIVLESLGVSLWALVTGLGLAGAGIAVAARDLIANLLAGLYLALERPFEVGD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RIRVGEYSGEVVDLRIRCTVLKSRGRRIVIPNSVLVNETVEKLDDSDECEFEVVVEGSPG
EEEECCCCCCEEEEEEEEEEEHHCCCEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCH
EIGRRLAALEKELDSLKLKYYEISVERVESGRTLVRVRTAGKEVDSVHGAVRRALVKRPG
HHHHHHHHHHHHHHHHEEHHEEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC
GTDR
CCCC
>Mature Secondary Structure
MELPSMKLPSAHVEPLKLATAIVIALLLVKIMGRAARAVRGKLEEEDLQDLGWWVEKTLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YGSYLLAFSIVLESLGVSLWALVTGLGLAGAGIAVAARDLIANLLAGLYLALERPFEVGD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RIRVGEYSGEVVDLRIRCTVLKSRGRRIVIPNSVLVNETVEKLDDSDECEFEVVVEGSPG
EEEECCCCCCEEEEEEEEEEEHHCCCEEEECCCHHHHHHHHHCCCCCCCCEEEEEECCCH
EIGRRLAALEKELDSLKLKYYEISVERVESGRTLVRVRTAGKEVDSVHGAVRRALVKRPG
HHHHHHHHHHHHHHHHEEHHEEEEHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCC
GTDR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]