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The map label for this gene is AroC

Identifier: 20094069

GI number: 20094069

Start: 592609

End: 593769

Strand: Direct

Name: AroC

Synonym: MK0631

Alternate gene names: 20094069

Gene position: 592609-593769 (Clockwise)

Preceding gene: 20094066

Following gene: 20094071

Centisome position: 34.96

GC content: 67.01

Gene sequence:

>1161_bases
GTGAACACGCTCGGCCGCCTGTTCCGCGTCACGACCTGGGGCGAGTCCCACGGTCCGGCACTGGGCGCGGTCGTGGACGG
GTGTCCCGCGGGACTACCGCTTTCCGAGGACGATGTGCAGCGTGAGCTGGATCGGAGGCGCCCCGGACAGTCGGGGGTCT
CGACACCGCGCTCGGAGCGGGACCGAGTGGAGATACTGTCGGGCGTCCACGAGGGACGCACTCTCGGGACTCCGATCAGT
ATGATCGTGTGGAACGAGGACGTGGATTCTTCGAAGTACGAGCCGATCCGAACCCGGCCGCGTCCGGGTCACGCCGACGT
CACGTACCGGTGGAAGTACGGGCACGTGGATTACCGGGGCGGTGGGAGGGCCTCGGGTCGCACGACCGTCGGTATCGTGA
TGGGTGGCGCGGTGGCCAAGAAGTTGCTCCGTGAGGCGCCCTCGAACGACCCGCTGGGTATCGAGATCGTGGGTCACGTG
GTGAGGGTGGGCTCCGTCGAGGCGGATCCCGGCGACCTGTCCGCGGAGGAGATCATGCAGTACGCCGAGTCGAACCCGGT
TAGATGCGCGGATCCTGACGCCGCCGAGGAGATGCTCGGGGAGATCGAGCGTGCGCGCGAGAACGGGGACTCCGTCGGCG
GGACGATCGAGGTGATCGCGGAGAACGTGCCACCCGGCCTGGGTGACCCGGTCTTCGGGCGGCTGGACGGGGAGCTAGCG
GGGGCGTTGATGAACATCCCCGCGGTGAAGGCGGTGGAGGTGGGGTCCGGTGTTCGATGCTCCGAGATGCACGGATCCGA
GCACAACGACCCGATCTGGTGGGACGGACATCCCGTCGTGGACGGCGACAACTCGGGGGGAGTACTCGGGGGTATTTCCC
ACGGCGGTAGACTGGTCGTCCGGGTGCACGTGAAACCTACTCCGTCCGTGTCCGTTCCCCAGCGCACCGTCGACCTAGAG
TCCGAAGAGGAAGTGGAGATCGAGGTGGAGGGACGACACGACCCCTGCATATGCCCGAGGGCTGTACCCGTGGCGGAATC
CGTTGTGGCGATCGTGCTGGCCGACGCCGTTCTCAGGGCCGGGTACGTGAACCCGGACAGTGTCGAGCTCCCGGCCGCGT
CCGTGGAGGATCGATGGAGGACGCTGAAACGACACCTATAG

Upstream 100 bases:

>100_bases
CACCTCGGTTCTCCGGAAATCGTGTTCCGGAATCCTTTACCTGGGTTTCGCCCGCCCCGATTTTTAAGTGACCGACGCGG
CGCCGTCGTGGGGGAGTCCC

Downstream 100 bases:

>100_bases
CCCCCTGAGCTCGAACCGGAACTCGCACCGGCCGACGAGCTCACCGGTCACGGCCGCACACTCGGTTTCCTCCACGCGTT
CGACCTCCTTGCCGAAGGTA

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNTLGRLFRVTTWGESHGPALGAVVDGCPAGLPLSEDDVQRELDRRRPGQSGVSTPRSERDRVEILSGVHEGRTLGTPIS
MIVWNEDVDSSKYEPIRTRPRPGHADVTYRWKYGHVDYRGGGRASGRTTVGIVMGGAVAKKLLREAPSNDPLGIEIVGHV
VRVGSVEADPGDLSAEEIMQYAESNPVRCADPDAAEEMLGEIERARENGDSVGGTIEVIAENVPPGLGDPVFGRLDGELA
GALMNIPAVKAVEVGSGVRCSEMHGSEHNDPIWWDGHPVVDGDNSGGVLGGISHGGRLVVRVHVKPTPSVSVPQRTVDLE
SEEEVEIEVEGRHDPCICPRAVPVAESVVAIVLADAVLRAGYVNPDSVELPAASVEDRWRTLKRHL

Sequences:

>Translated_386_residues
MNTLGRLFRVTTWGESHGPALGAVVDGCPAGLPLSEDDVQRELDRRRPGQSGVSTPRSERDRVEILSGVHEGRTLGTPIS
MIVWNEDVDSSKYEPIRTRPRPGHADVTYRWKYGHVDYRGGGRASGRTTVGIVMGGAVAKKLLREAPSNDPLGIEIVGHV
VRVGSVEADPGDLSAEEIMQYAESNPVRCADPDAAEEMLGEIERARENGDSVGGTIEVIAENVPPGLGDPVFGRLDGELA
GALMNIPAVKAVEVGSGVRCSEMHGSEHNDPIWWDGHPVVDGDNSGGVLGGISHGGRLVVRVHVKPTPSVSVPQRTVDLE
SEEEVEIEVEGRHDPCICPRAVPVAESVVAIVLADAVLRAGYVNPDSVELPAASVEDRWRTLKRHL
>Mature_386_residues
MNTLGRLFRVTTWGESHGPALGAVVDGCPAGLPLSEDDVQRELDRRRPGQSGVSTPRSERDRVEILSGVHEGRTLGTPIS
MIVWNEDVDSSKYEPIRTRPRPGHADVTYRWKYGHVDYRGGGRASGRTTVGIVMGGAVAKKLLREAPSNDPLGIEIVGHV
VRVGSVEADPGDLSAEEIMQYAESNPVRCADPDAAEEMLGEIERARENGDSVGGTIEVIAENVPPGLGDPVFGRLDGELA
GALMNIPAVKAVEVGSGVRCSEMHGSEHNDPIWWDGHPVVDGDNSGGVLGGISHGGRLVVRVHVKPTPSVSVPQRTVDLE
SEEEVEIEVEGRHDPCICPRAVPVAESVVAIVLADAVLRAGYVNPDSVELPAASVEDRWRTLKRHL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=366, Percent_Identity=49.4535519125683, Blast_Score=306, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6321290, Length=369, Percent_Identity=43.9024390243902, Blast_Score=313, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_METKA (Q8TXN1)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613916.1
- ProteinModelPortal:   Q8TXN1
- GeneID:   1476732
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0631
- NMPDR:   fig|190192.1.peg.629
- HOGENOM:   HBG292336
- OMA:   TATIGKE
- ProtClustDB:   PRK05382
- BioCyc:   MKAN190192:MK0631-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_A
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 41329; Mature: 41329

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTLGRLFRVTTWGESHGPALGAVVDGCPAGLPLSEDDVQRELDRRRPGQSGVSTPRSER
CCCHHCEEEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHH
DRVEILSGVHEGRTLGTPISMIVWNEDVDSSKYEPIRTRPRPGHADVTYRWKYGHVDYRG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEECC
GGRASGRTTVGIVMGGAVAKKLLREAPSNDPLGIEIVGHVVRVGSVEADPGDLSAEEIMQ
CCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCHHEEEHHHHCCCCCCCCCCCCHHHHHH
YAESNPVRCADPDAAEEMLGEIERARENGDSVGGTIEVIAENVPPGLGDPVFGRLDGELA
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
GALMNIPAVKAVEVGSGVRCSEMHGSEHNDPIWWDGHPVVDGDNSGGVLGGISHGGRLVV
HHHHCCCCEEEEECCCCCEEHHCCCCCCCCCEEECCEEEECCCCCCCEEEEECCCCEEEE
RVHVKPTPSVSVPQRTVDLESEEEVEIEVEGRHDPCICPRAVPVAESVVAIVLADAVLRA
EEEECCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GYVNPDSVELPAASVEDRWRTLKRHL
CCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNTLGRLFRVTTWGESHGPALGAVVDGCPAGLPLSEDDVQRELDRRRPGQSGVSTPRSER
CCCHHCEEEEEECCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHH
DRVEILSGVHEGRTLGTPISMIVWNEDVDSSKYEPIRTRPRPGHADVTYRWKYGHVDYRG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCEEECC
GGRASGRTTVGIVMGGAVAKKLLREAPSNDPLGIEIVGHVVRVGSVEADPGDLSAEEIMQ
CCCCCCCEEEEEEECHHHHHHHHHHCCCCCCCCHHEEEHHHHCCCCCCCCCCCCHHHHHH
YAESNPVRCADPDAAEEMLGEIERARENGDSVGGTIEVIAENVPPGLGDPVFGRLDGELA
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHH
GALMNIPAVKAVEVGSGVRCSEMHGSEHNDPIWWDGHPVVDGDNSGGVLGGISHGGRLVV
HHHHCCCCEEEEECCCCCEEHHCCCCCCCCCEEECCEEEECCCCCCCEEEEECCCCEEEE
RVHVKPTPSVSVPQRTVDLESEEEVEIEVEGRHDPCICPRAVPVAESVVAIVLADAVLRA
EEEECCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GYVNPDSVELPAASVEDRWRTLKRHL
CCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014