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The map label for this gene is cofC

Identifier: 20094025

GI number: 20094025

Start: 545951

End: 546523

Strand: Direct

Name: cofC

Synonym: MK0587

Alternate gene names: 20094025

Gene position: 545951-546523 (Clockwise)

Preceding gene: 20094024

Following gene: 20094026

Centisome position: 32.21

GC content: 62.3

Gene sequence:

>573_bases
GTGAGGTTCGTGGTGCCGTTCGCGGATAGGGGGGATCGTAAGACCCGGCTGTCCTCGTGCATGGACGAGGAGACGCGTGA
GCGGTTCGCGTTGGCGATGCTAAGGCACGTGGTAAGGGTGCTCTCCAAGTTCGGCGAGGTAGAAGTGGTAACTCCGGACT
CCAGCCTGTCGGTGCCGGGGACGAAGGTACGACGGAGTGACGCGAGTCTCGACGAGCTGCCGCTTCCGGACGGTGAGTTC
GGGCTGGTGATGTCGGATCTACCGTTGCTGTCCGAAGAGGACGTCGAGCGGGCGTTGGAGGGGTTGAAAGACGCGGATGT
CGTTCTCTGCCCGTCCCGACGAGGTGGAACGAGTGGAGTGTTCGTGAGGAAGGGTGTACGGTTCAGGCCGACGTTCGGTG
GTGTGAGCTTCCCTAGGAACTTGAGACGGGCGGAGAAGCAAGGGGTGGAAGTCGCCGTGGTGAAGTCGTTGGGGTTCTTC
GCCGATGTGGACGAGCCGGAAGACCTGCTCGACGCGGCGTTGTTGGGGAGGAGGGAAGTGGCGAAGATTGCGCGTTCCGT
CGTCGAAGTCTGA

Upstream 100 bases:

>100_bases
CCCGCGTACTCGACTTAGACACGGATGCAGATCCGGAGGATCCAAGCGACTTCGTCGAGGTATGGGGGAACGTGATGTCG
GTGCTGGGGGAGCTTAAGCC

Downstream 100 bases:

>100_bases
CGGCACCTTTTGTGCGACTTTCATTAGAGAGTCCCGTGAGACGACACGCACCGGAGGGGGCCGGATTAAAGAAGCGTGGA
GCGCGCCCGGGCAGGGGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MRFVVPFADRGDRKTRLSSCMDEETRERFALAMLRHVVRVLSKFGEVEVVTPDSSLSVPGTKVRRSDASLDELPLPDGEF
GLVMSDLPLLSEEDVERALEGLKDADVVLCPSRRGGTSGVFVRKGVRFRPTFGGVSFPRNLRRAEKQGVEVAVVKSLGFF
ADVDEPEDLLDAALLGRREVAKIARSVVEV

Sequences:

>Translated_190_residues
MRFVVPFADRGDRKTRLSSCMDEETRERFALAMLRHVVRVLSKFGEVEVVTPDSSLSVPGTKVRRSDASLDELPLPDGEF
GLVMSDLPLLSEEDVERALEGLKDADVVLCPSRRGGTSGVFVRKGVRFRPTFGGVSFPRNLRRAEKQGVEVAVVKSLGFF
ADVDEPEDLLDAALLGRREVAKIARSVVEV
>Mature_190_residues
MRFVVPFADRGDRKTRLSSCMDEETRERFALAMLRHVVRVLSKFGEVEVVTPDSSLSVPGTKVRRSDASLDELPLPDGEF
GLVMSDLPLLSEEDVERALEGLKDADVVLCPSRRGGTSGVFVRKGVRFRPTFGGVSFPRNLRRAEKQGVEVAVVKSLGFF
ADVDEPEDLLDAALLGRREVAKIARSVVEV

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_METKA (Q8TXS3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613872.1
- ProteinModelPortal:   Q8TXS3
- SMR:   Q8TXS3
- GeneID:   1476688
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0587
- NMPDR:   fig|190192.1.peg.585
- HOGENOM:   HBG699055
- OMA:   IVMADLP
- BioCyc:   MKAN190192:MK0587-MONOMER
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 20960; Mature: 20960

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVVPFADRGDRKTRLSSCMDEETRERFALAMLRHVVRVLSKFGEVEVVTPDSSLSVPG
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
TKVRRSDASLDELPLPDGEFGLVMSDLPLLSEEDVERALEGLKDADVVLCPSRRGGTSGV
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCE
FVRKGVRFRPTFGGVSFPRNLRRAEKQGVEVAVVKSLGFFADVDEPEDLLDAALLGRREV
EEECCCEECCCCCCCCCCHHHHHHHHCCCEEEEEHHCCCCCCCCCHHHHHHHHHHCHHHH
AKIARSVVEV
HHHHHHHHCC
>Mature Secondary Structure
MRFVVPFADRGDRKTRLSSCMDEETRERFALAMLRHVVRVLSKFGEVEVVTPDSSLSVPG
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
TKVRRSDASLDELPLPDGEFGLVMSDLPLLSEEDVERALEGLKDADVVLCPSRRGGTSGV
CHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCE
FVRKGVRFRPTFGGVSFPRNLRRAEKQGVEVAVVKSLGFFADVDEPEDLLDAALLGRREV
EEECCCEECCCCCCCCCCHHHHHHHHCCCEEEEEHHCCCCCCCCCHHHHHHHHHHCHHHH
AKIARSVVEV
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014