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The map label for this gene is atoB [H]

Identifier: 18311177

GI number: 18311177

Start: 2515294

End: 2516472

Strand: Reverse

Name: atoB [H]

Synonym: CPE2195

Alternate gene names: 18311177

Gene position: 2516472-2515294 (Counterclockwise)

Preceding gene: 18311178

Following gene: 18311176

Centisome position: 83.01

GC content: 35.54

Gene sequence:

>1179_bases
ATGAGAGAGGTAGTTATTGCAAGTGCAGTAAGAACAGCATTAGGTTCATTTGGTGGTTCATTAAAGGATGTTCCTGCTGT
AGATTTAGGAGCTTTAGTTATTAAAGAAGCTTTAAATAAAGCTGGTGTAAAACCAGAATGTGTTGATGAAGTTTTAATGG
GAAATGTAATTCAAGCTGGATTAGGACAAAACCCTGCAAGACAAGCAGCTGTAAAAGCTGGTTTACCAGTTGAAATTCCT
TCAATGACAATAAATAAAGTTTGTGGTTCAGGTTTAAGATGTGTTGCTTTAGCAGCTCAAATGATAAAAGCAGGAGATGC
TGACGTAATAGTAGCTGGTGGTATGGAAAACATGTCACAAGGACCATATGTTTTAAGAACTGCAAGATTTGGTCAAAGAA
TGGGCGATGGAAAAATGGTCGATGCTATGGTCAATGATGCTTTAACAGATGCATTTAATGGATACCACATGGGTATAACT
GCTGAAAATATAGCAGAACAATGGGGATTAACTAGAGAAATGCAAGATGAATTTGCTGCAAATTCTCAAATTAAAGCAGA
AGCAGCTATAAAAGCTGGAAAATTCAAAGATGAAATAGTTCCAGTAGTAATTCCACAAAGAAAAGGTGATCCAATAGTAT
TTGATACTGATGAATTCCCTAGATTTGGAACAACTGCTGAAAAATTAGCTAAGTTAAGACCAGCATTCAAAAAAGATGGT
ACAGTTACAGCTGGTAATGCATCAGGTATAAATGATGGTGCTGCTGCATTAGTTGTTATGAGTGCTGAAAAAGCAAAAGA
ATTAGGAGTAACTCCAATTTGTAAAATAGTTTCTTATGGTTCAAAAGGATTAGATCCTTCAATTATGGGTTATGGACCAT
TCTATGCTACTAAAAAAGCTTTAGAAGGAACTGGATTAACAGTTGCAGATCTTGATTTAATAGAAGCAAATGAAGCTTTT
GCAGCTCAAAGTTTAGCAGTTGCTAAAGATTTAGAATTTGATATGAGTAAAGTTAACGTAAATGGTGGAGCTATAGCTTT
AGGACATCCAGTAGGAGCTTCAGGGGCTAGAATATTAGTTACATTACTTCACGAAATGATGAAAAGAGATGCTAAGAGAG
GTTTAGCAACACTTTGTATAGGTGGAGGAATGGGAACTGCTTTAATAGTAGAAAGATAA

Upstream 100 bases:

>100_bases
CAAAAAATATTGAAAGCTAGTAAATTTATGGTTATAATTAAATCAGTTAGAAAAAATATAGATTTTTGATAAATTTTTAC
CTAAATGGGAGGTTTTTGAT

Downstream 100 bases:

>100_bases
TAAGTTTACCATTATTATAATATATATTTTAAAGATACTATCCTATCTTGGGATAGTATCTTTTTTTGTGAAAAATTATT
TAAAATTCATGTTTAAGTTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MREVVIASAVRTALGSFGGSLKDVPAVDLGALVIKEALNKAGVKPECVDEVLMGNVIQAGLGQNPARQAAVKAGLPVEIP
SMTINKVCGSGLRCVALAAQMIKAGDADVIVAGGMENMSQGPYVLRTARFGQRMGDGKMVDAMVNDALTDAFNGYHMGIT
AENIAEQWGLTREMQDEFAANSQIKAEAAIKAGKFKDEIVPVVIPQRKGDPIVFDTDEFPRFGTTAEKLAKLRPAFKKDG
TVTAGNASGINDGAAALVVMSAEKAKELGVTPICKIVSYGSKGLDPSIMGYGPFYATKKALEGTGLTVADLDLIEANEAF
AAQSLAVAKDLEFDMSKVNVNGGAIALGHPVGASGARILVTLLHEMMKRDAKRGLATLCIGGGMGTALIVER

Sequences:

>Translated_392_residues
MREVVIASAVRTALGSFGGSLKDVPAVDLGALVIKEALNKAGVKPECVDEVLMGNVIQAGLGQNPARQAAVKAGLPVEIP
SMTINKVCGSGLRCVALAAQMIKAGDADVIVAGGMENMSQGPYVLRTARFGQRMGDGKMVDAMVNDALTDAFNGYHMGIT
AENIAEQWGLTREMQDEFAANSQIKAEAAIKAGKFKDEIVPVVIPQRKGDPIVFDTDEFPRFGTTAEKLAKLRPAFKKDG
TVTAGNASGINDGAAALVVMSAEKAKELGVTPICKIVSYGSKGLDPSIMGYGPFYATKKALEGTGLTVADLDLIEANEAF
AAQSLAVAKDLEFDMSKVNVNGGAIALGHPVGASGARILVTLLHEMMKRDAKRGLATLCIGGGMGTALIVER
>Mature_392_residues
MREVVIASAVRTALGSFGGSLKDVPAVDLGALVIKEALNKAGVKPECVDEVLMGNVIQAGLGQNPARQAAVKAGLPVEIP
SMTINKVCGSGLRCVALAAQMIKAGDADVIVAGGMENMSQGPYVLRTARFGQRMGDGKMVDAMVNDALTDAFNGYHMGIT
AENIAEQWGLTREMQDEFAANSQIKAEAAIKAGKFKDEIVPVVIPQRKGDPIVFDTDEFPRFGTTAEKLAKLRPAFKKDG
TVTAGNASGINDGAAALVVMSAEKAKELGVTPICKIVSYGSKGLDPSIMGYGPFYATKKALEGTGLTVADLDLIEANEAF
AAQSLAVAKDLEFDMSKVNVNGGAIALGHPVGASGARILVTLLHEMMKRDAKRGLATLCIGGGMGTALIVER

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=53.7084398976982, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=45.6632653061224, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=46.0759493670886, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=42.0654911838791, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI4504327, Length=431, Percent_Identity=33.1786542923434, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=30.8673469387755, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=63.3587786259542, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=56.1224489795918, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44.5, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=44, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788683, Length=424, Percent_Identity=35.377358490566, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.6666666666667, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=40.6649616368286, Blast_Score=296, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.676844783715, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=33.0985915492958, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=31.7258883248731, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.2211055276382, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=39.9002493765586, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=53.0612244897959, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.6410256410256, Blast_Score=321, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=44.6428571428571, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=32.2505800464037, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40838; Mature: 40838

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVVIASAVRTALGSFGGSLKDVPAVDLGALVIKEALNKAGVKPECVDEVLMGNVIQAG
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQAAVKAGLPVEIPSMTINKVCGSGLRCVALAAQMIKAGDADVIVAGGMENMSQ
CCCCHHHHHHHHCCCCEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
GPYVLRTARFGQRMGDGKMVDAMVNDALTDAFNGYHMGITAENIAEQWGLTREMQDEFAA
CCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCHHHHHHHHC
NSQIKAEAAIKAGKFKDEIVPVVIPQRKGDPIVFDTDEFPRFGTTAEKLAKLRPAFKKDG
CCCCCHHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCHHHCCC
TVTAGNASGINDGAAALVVMSAEKAKELGVTPICKIVSYGSKGLDPSIMGYGPFYATKKA
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCHHHHHHHHCCCCCCCCCCEECCCHHHHHHH
LEGTGLTVADLDLIEANEAFAAQSLAVAKDLEFDMSKVNVNGGAIALGHPVGASGARILV
HCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHH
TLLHEMMKRDAKRGLATLCIGGGMGTALIVER
HHHHHHHHHHHHCCEEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MREVVIASAVRTALGSFGGSLKDVPAVDLGALVIKEALNKAGVKPECVDEVLMGNVIQAG
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
LGQNPARQAAVKAGLPVEIPSMTINKVCGSGLRCVALAAQMIKAGDADVIVAGGMENMSQ
CCCCHHHHHHHHCCCCEECCCCHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
GPYVLRTARFGQRMGDGKMVDAMVNDALTDAFNGYHMGITAENIAEQWGLTREMQDEFAA
CCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCHHHHHHHHC
NSQIKAEAAIKAGKFKDEIVPVVIPQRKGDPIVFDTDEFPRFGTTAEKLAKLRPAFKKDG
CCCCCHHHHHHCCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCHHHCCC
TVTAGNASGINDGAAALVVMSAEKAKELGVTPICKIVSYGSKGLDPSIMGYGPFYATKKA
CEEECCCCCCCCCCEEEEEEEHHHHHHCCCHHHHHHHHCCCCCCCCCCEECCCHHHHHHH
LEGTGLTVADLDLIEANEAFAAQSLAVAKDLEFDMSKVNVNGGAIALGHPVGASGARILV
HCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCCCHHHHHH
TLLHEMMKRDAKRGLATLCIGGGMGTALIVER
HHHHHHHHHHHHCCEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]