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The map label for this gene is wecB [C]

Identifier: 18311178

GI number: 18311178

Start: 2516741

End: 2517895

Strand: Reverse

Name: wecB [C]

Synonym: CPE2196

Alternate gene names: 18311178

Gene position: 2517895-2516741 (Counterclockwise)

Preceding gene: 18311179

Following gene: 18311177

Centisome position: 83.06

GC content: 30.04

Gene sequence:

>1155_bases
ATGGAAAAGATAAAAGTTTTAACTATCTTTGGAACAAGACCGGAAGCTATAAAAATGGCTCCATTAGTAAAAGAATTAGA
AAAAAGACCGGAAATAGAATCAAAGGTTTGTGTAACTGCTCAACATAGAGAAATGTTAGATCAAGTTTTAGAACTATTTG
ATATAAAGCCTGACTTTGATCTAGACATAATGAAAAATCGTCAAACTCTTACTGGAATAACAAATAGAGTTTTAGAAGGA
TTAGAAAAAGTATTTACAGAAGAAAAACCAGATATGATACTTGTACATGGTGATACTACAACAACTTTTGCTGGAGGATT
AGCAGCATTCTATCAACAAATAAGAGTAGGTCATGTTGAGGCGGGACTTAGAACTTTCGATAAATATTTCCCATTCCCAG
AGGAAATGAATAGAAAGTTAACAGGTGCTTTAGCTGATTTACACTTTGCTCCAACTAAAGGATCAAAAGCTAACCTTTTA
AGAGAAGGAATAAATGAAAATGACATAAAAATTACAGGTAACACTGTAATCGATGCTATGGAACATACTGTAGAAGATAA
CTATGTTTTTGAAAATGATGAATTAAATAAAATAGATTTTGAAAACAAAAAAGTTATCATGATAACTGCACATAGAAGAG
AAAACTGGGGAGAAGGTATAGAAAATATCTGTACAGCTTTAAATAAAATAGTTGAAGATAATAAAGATGTTGAATTAGTT
TACCTTGTTCACTTAAATCCAGTTGTAAAAGATGTTGTTTATAAAAATCTTGATGGTAAAGAAAGAGTACATCTTTTACC
ACCACTTGATACAAAAGAAACTCATAACTTAATGAATAAATGCTTTATGGTTATGACTGATTCAGGTGGATTACAAGAAG
AAGCTCCTCATTTAGGAAAACCAGTATTAGTTTTAAGAGATGTTACAGAAAGACCAGAAGCTGTTCAATCAGGAACAGTT
AAATTAGTTGGTACTGATGTTGAAAAAATATTAGAAGAAGCTAATTCACTTATAAATGATGAAAAAGCTTATGCCAAAAT
GAGTAAAGCTATAAATCCATATGGAGATGGTAAGGCTTCTGAAAGAATAGTAAAAGCTATTTTAAATTACTTTGGAAAAA
ATGATGAAGAAGTAGAAGAATTTATAAGTAAATAA

Upstream 100 bases:

>100_bases
AGGTGATGCAGGAGATAGACTATTTGGAACAAAATAGTTATAATTTAAATAGCTACTTAATTTTAAGTAGCTATTAATTA
TTTTTGGAGGTAAATGATTC

Downstream 100 bases:

>100_bases
GACTTTGTTAAAAAAGTTTAATAAATATAATTTGAATAAATGGTATAAATAGACAGATATTTAGAATATTATAGAAATTT
TAATAAAAGACTTCTATAAT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MEKIKVLTIFGTRPEAIKMAPLVKELEKRPEIESKVCVTAQHREMLDQVLELFDIKPDFDLDIMKNRQTLTGITNRVLEG
LEKVFTEEKPDMILVHGDTTTTFAGGLAAFYQQIRVGHVEAGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKANLL
REGINENDIKITGNTVIDAMEHTVEDNYVFENDELNKIDFENKKVIMITAHRRENWGEGIENICTALNKIVEDNKDVELV
YLVHLNPVVKDVVYKNLDGKERVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGKPVLVLRDVTERPEAVQSGTV
KLVGTDVEKILEEANSLINDEKAYAKMSKAINPYGDGKASERIVKAILNYFGKNDEEVEEFISK

Sequences:

>Translated_384_residues
MEKIKVLTIFGTRPEAIKMAPLVKELEKRPEIESKVCVTAQHREMLDQVLELFDIKPDFDLDIMKNRQTLTGITNRVLEG
LEKVFTEEKPDMILVHGDTTTTFAGGLAAFYQQIRVGHVEAGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKANLL
REGINENDIKITGNTVIDAMEHTVEDNYVFENDELNKIDFENKKVIMITAHRRENWGEGIENICTALNKIVEDNKDVELV
YLVHLNPVVKDVVYKNLDGKERVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGKPVLVLRDVTERPEAVQSGTV
KLVGTDVEKILEEANSLINDEKAYAKMSKAINPYGDGKASERIVKAILNYFGKNDEEVEEFISK
>Mature_384_residues
MEKIKVLTIFGTRPEAIKMAPLVKELEKRPEIESKVCVTAQHREMLDQVLELFDIKPDFDLDIMKNRQTLTGITNRVLEG
LEKVFTEEKPDMILVHGDTTTTFAGGLAAFYQQIRVGHVEAGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKANLL
REGINENDIKITGNTVIDAMEHTVEDNYVFENDELNKIDFENKKVIMITAHRRENWGEGIENICTALNKIVEDNKDVELV
YLVHLNPVVKDVVYKNLDGKERVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGKPVLVLRDVTERPEAVQSGTV
KLVGTDVEKILEEANSLINDEKAYAKMSKAINPYGDGKASERIVKAILNYFGKNDEEVEEFISK

Specific function: Catalyzes The Reversible Epimerization At C-2 Of UDP-N- Acetylglucosamine (UDP-Glcnac) And Thereby Provides Bacteria With UDP-N-Acetylmannosamine (UDP-Mannac), The Activated Donor Of Mannac Residues. Also Involved In Bacteriophage N4 Adsorption. [C]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=374, Percent_Identity=57.7540106951872, Blast_Score=398, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43468; Mature: 43468

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIKVLTIFGTRPEAIKMAPLVKELEKRPEIESKVCVTAQHREMLDQVLELFDIKPDFD
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHCCCCCCC
LDIMKNRQTLTGITNRVLEGLEKVFTEEKPDMILVHGDTTTTFAGGLAAFYQQIRVGHVE
CHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
AGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKANLLREGINENDIKITGNTVIDAM
HHHHHHHHHCCCHHHHHHHHHHHHHHCEECCCCCCHHHHHHCCCCCCCEEEECCHHHHHH
EHTVEDNYVFENDELNKIDFENKKVIMITAHRRENWGEGIENICTALNKIVEDNKDVELV
HHHHCCCEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YLVHLNPVVKDVVYKNLDGKERVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGK
EEEECCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHEEEEEECCCCCCCCCCCCCC
PVLVLRDVTERPEAVQSGTVKLVGTDVEKILEEANSLINDEKAYAKMSKAINPYGDGKAS
CEEEEECCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHH
ERIVKAILNYFGKNDEEVEEFISK
HHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MEKIKVLTIFGTRPEAIKMAPLVKELEKRPEIESKVCVTAQHREMLDQVLELFDIKPDFD
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHEEEHHHHHHHHHHHHHHCCCCCCC
LDIMKNRQTLTGITNRVLEGLEKVFTEEKPDMILVHGDTTTTFAGGLAAFYQQIRVGHVE
CHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
AGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKANLLREGINENDIKITGNTVIDAM
HHHHHHHHHCCCHHHHHHHHHHHHHHCEECCCCCCHHHHHHCCCCCCCEEEECCHHHHHH
EHTVEDNYVFENDELNKIDFENKKVIMITAHRRENWGEGIENICTALNKIVEDNKDVELV
HHHHCCCEEECCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
YLVHLNPVVKDVVYKNLDGKERVHLLPPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGK
EEEECCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHEEEEEECCCCCCCCCCCCCC
PVLVLRDVTERPEAVQSGTVKLVGTDVEKILEEANSLINDEKAYAKMSKAINPYGDGKAS
CEEEEECCCCCCHHHHCCCEEEEECCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCHHH
ERIVKAILNYFGKNDEEVEEFISK
HHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286; 7867955 [H]