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The map label for this gene is phcR [H]

Identifier: 17547456

GI number: 17547456

Start: 2946168

End: 2947292

Strand: Direct

Name: phcR [H]

Synonym: RSc2737

Alternate gene names: 17547456

Gene position: 2946168-2947292 (Clockwise)

Preceding gene: 17547455

Following gene: 17547457

Centisome position: 79.27

GC content: 68.8

Gene sequence:

>1125_bases
ATGGACGCCACGCCCGACACCGGCCCGACCATCCTGTATGTGGACGACGAGCAGCAGGCCTGCAAGTGGTTCACGCGCAT
GGTCTCGGCCAGCTACAACGTGCTGACGGCCAACAGCGTGGAAGAAGCCAAGGCGGTGCTGCGCGACGCGCACGACCGCA
TCGGCGTGGTGCTGACCGACTTCCGCATGCCCGGCGGCGACGGCACCGAGCTGCTGCGCTTCATCGACGCGGAATACAGC
GACATCGCCGCCATCCTCGTCACCGCGTACGCCGACAAGGACCTGCTGATCCAGGCCGTCAACACCGGGCGGGTCTTCAA
GATCCTGGAGAAGCCCTACCAGCCGGAGGACGTGCGGCGCTCGCTGCAGGAGGCGCTGGCACTGCGCCAGGACCGCCTGC
TGCGCACGCAGCGCTTGATGGCCATCGACGAGACGCTGGCGTTTCTCGCCCACGAACTGAACACCCCGCTGGCCGCCATC
GCCAACTTCGCGCGCGGCATCCGCATGCGCGTCGACCAGACCGAGCCGGCCCCGGACACGCTGCCCGGCATCGGCCGCGC
CGCCGACCGCGTGCAGGACAACGCGCGCTACTGCCTGTCGGTGCTGTCGACCTTCCTGAATTCGGTGCGGCACGCGCACG
GCAAGTCGGAAGCGGCGTCGGCATCGGCGCCCAGCAGCGCAGCCGGCCTCATCCGCTCGCTGCTCGACACCTATCCGTTC
ACCGCGGTGCAGCGCGATTGGGTGTCCTACCGGATCGAGCGGGACTTCCCGATCCTGACGCTGCCCAACTGCGTGATGCT
GGTGCTGTCGTCGCTGACCAGCAACGCGCTGCACGCGCTGCGGCATACCGAGGCGCCACGGCTGGAGATCGTCGCCGCGG
GCGCGGCGGCGCTCAACGGCACGCCCGGTGCCGGCCATACGATCCGCATCGAAGACAACGGCCCCGGCATCGCGCCCGAC
ATCCTGGCGCGGCTGACCATCGACCCCGTGACCACGCGCGCCGAAGAAGGCGGCAATGGCATGGGCATGATTTTCTGTAC
GCGGATCATGCAGTCGTTCGGAGGCGGGATCGCCATCGATTCCGCCCCGAGCGCAGGCACGCGCGTGACCCTGACGTTCC
CATGA

Upstream 100 bases:

>100_bases
GCGTGATCCAGCACCACGGCGGGACACTCTCGGTGGCCAGCCTGGAAGGCGAATGGGCACGCTTCACCTTCGATCTGCCG
CGCGCGGAATAGGAGCGAGC

Downstream 100 bases:

>100_bases
ACCGAGCGATACCAGGCACCACGCCGTACCTGATCCGCGTTTTTGCTAAGAGGAGTGATGGATGACCAACCCCGGGGACA
ATGAGCCCAAGATCCTGTAT

Product: two component response regulator transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTDFRMPGGDGTELLRFIDAEYS
DIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRRSLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAI
ANFARGIRMRVDQTEPAPDTLPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNGTPGAGHTIRIEDNGPGIAPD
ILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAIDSAPSAGTRVTLTFP

Sequences:

>Translated_374_residues
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTDFRMPGGDGTELLRFIDAEYS
DIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRRSLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAI
ANFARGIRMRVDQTEPAPDTLPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNGTPGAGHTIRIEDNGPGIAPD
ILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAIDSAPSAGTRVTLTFP
>Mature_374_residues
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTDFRMPGGDGTELLRFIDAEYS
DIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRRSLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAI
ANFARGIRMRVDQTEPAPDTLPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNGTPGAGHTIRIEDNGPGIAPD
ILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAIDSAPSAGTRVTLTFP

Specific function: Member of the two-component regulatory system dctS/dctR involved in the transport of C4-dicarboxylates. DctS functions as a membrane-associated protein kinase that phosphorylates dctR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=255, Percent_Identity=26.6666666666667, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40488; Mature: 40488

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTD
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCEEEEE
FRMPGGDGTELLRFIDAEYSDIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRR
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCHHHHH
SLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAIANFARGIRMRVDQTEPAPDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCC
LPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCC
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNG
HHHHHHHHHEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCC
TPGAGHTIRIEDNGPGIAPDILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAID
CCCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
SAPSAGTRVTLTFP
CCCCCCCEEEEECC
>Mature Secondary Structure
MDATPDTGPTILYVDDEQQACKWFTRMVSASYNVLTANSVEEAKAVLRDAHDRIGVVLTD
CCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCEEEEE
FRMPGGDGTELLRFIDAEYSDIAAILVTAYADKDLLIQAVNTGRVFKILEKPYQPEDVRR
EECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHCCCCCHHHHH
SLQEALALRQDRLLRTQRLMAIDETLAFLAHELNTPLAAIANFARGIRMRVDQTEPAPDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEECCCCCCCCC
LPGIGRAADRVQDNARYCLSVLSTFLNSVRHAHGKSEAASASAPSSAAGLIRSLLDTYPF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCC
TAVQRDWVSYRIERDFPILTLPNCVMLVLSSLTSNALHALRHTEAPRLEIVAAGAAALNG
HHHHHHHHHEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCC
TPGAGHTIRIEDNGPGIAPDILARLTIDPVTTRAEEGGNGMGMIFCTRIMQSFGGGIAID
CCCCCCEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEC
SAPSAGTRVTLTFP
CCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8455557 [H]