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The map label for this gene is phcS [H]

Identifier: 17547455

GI number: 17547455

Start: 2944831

End: 2946159

Strand: Direct

Name: phcS [H]

Synonym: RSc2736

Alternate gene names: 17547455

Gene position: 2944831-2946159 (Clockwise)

Preceding gene: 17547454

Following gene: 17547456

Centisome position: 79.24

GC content: 64.64

Gene sequence:

>1329_bases
ATGATCGCCGCCAACTACCAGGGCTATCACCAGGAGCTGTCCGATCTGCGGCTGGCCTTCAGCCGCAGCGGAGCCGTCAC
GGGCGTCGTGCTGGTGATGCTCGGCGTGGGGCTCGACTACGGCCTGTATCCGCAGCATCAGGTGCTGTTCGGCGTCGCGC
GGTTCCTCGTCTCGCTGATGATGCTGACCGTGATGCTCGGCCTCCCCACGCGATGGGGCCGGCCGCGCGTGCAGGCGCTG
ACGCTGCTGTGGCTCGTGCTGCCGCAGCTCATGATCGTCTGGATGATCTGGTACACCGATGGCGCCGAATCGCTGTATTA
CGCGGGGCTCAACCTGGCGATCTTCGCGGTCGGCATCGTCATGCCGCTGGGGTTCCTGCAGACGGTGCTGTTCGGGGCCT
TCACGTACATCATCTGGGTCATCGCCTGCGTGATGCACGCCGGCGGCATCCAATCGCGCGGCACGTTCATCGTGCACTCG
CTGTTCATCCTGTTTTCGGTCGTGGCCAGCGCGGTCTACACCTACTTCAACGAACTGGGCCGATTCCAGCTCTTCCAGCT
GAAAGAGGAACTGGCCGAAAAGAACGAGCAGCTGGAAGCCATCAACCACAGCCTCACCGAGATCAAGGGGCAATTGCTGC
AGCAGGAGAAGATGGTCGCCATCGGCACCCTGTCGGCCGGCCTGCTGCACGAGATCAACAACCCCGTCAACTTCTGCCTG
ATGGCGATCGCGGTGGCGCAGGAAGACAGCACCGCCAAGGCCAGCCCGATGCTGCTCGAATGCCTGGCCGACGCCAAGGA
AGGCATGCAGCGCGTCCAGCACATCGTCTCCGACCTGAAGACCTTCGCCTACCGCAGCCCCGAGAAGGGCGTGGCCGACA
CGCCCTTCCTGGCGGAAAAGGCCATCGATTCGGCCATCCGCCTGACCAGCCACGAGCTGCGCGGCGTGGAAGTAAACCGC
CAGTTGCCGCCCGACACGCTGGTGCGCGGCGACGAAGCCGCCATCATCGGCGTGCTGATCAACCTGCTGTCCAATGCCGC
GCTGGCGATGCACAAGGCGCAGCGCGAGCACCCGTGCATCGACATCTCGGCGGAGTGGCACAACGGCCGGCTGTACGTGG
TCGTCAAGGACAACGGGCCCGGCATCGCGGAGAAGAACCTGTCGCGCGTGTTCGAGCCGTTCTTCACCACGCGCGAAGTC
GGCAAGGGCCTGGGACTGGGCCTGTCGATCAGCTACAGCGTGATCCAGCACCACGGCGGGACACTCTCGGTGGCCAGCCT
GGAAGGCGAATGGGCACGCTTCACCTTCGATCTGCCGCGCGCGGAATAG

Upstream 100 bases:

>100_bases
CCGCCGGGCTCGGAGCAGGTCCGCGTCTTCACCGACGATACCGGTGTCAACGTGTTCGCCCACGCCGACGTGGCAGCCAT
CGCCTGAGAGCGCACGCACC

Downstream 100 bases:

>100_bases
GAGCGAGCATGGACGCCACGCCCGACACCGGCCCGACCATCCTGTATGTGGACGACGAGCAGCAGGCCTGCAAGTGGTTC
ACGCGCATGGTCTCGGCCAG

Product: transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MIAANYQGYHQELSDLRLAFSRSGAVTGVVLVMLGVGLDYGLYPQHQVLFGVARFLVSLMMLTVMLGLPTRWGRPRVQAL
TLLWLVLPQLMIVWMIWYTDGAESLYYAGLNLAIFAVGIVMPLGFLQTVLFGAFTYIIWVIACVMHAGGIQSRGTFIVHS
LFILFSVVASAVYTYFNELGRFQLFQLKEELAEKNEQLEAINHSLTEIKGQLLQQEKMVAIGTLSAGLLHEINNPVNFCL
MAIAVAQEDSTAKASPMLLECLADAKEGMQRVQHIVSDLKTFAYRSPEKGVADTPFLAEKAIDSAIRLTSHELRGVEVNR
QLPPDTLVRGDEAAIIGVLINLLSNAALAMHKAQREHPCIDISAEWHNGRLYVVVKDNGPGIAEKNLSRVFEPFFTTREV
GKGLGLGLSISYSVIQHHGGTLSVASLEGEWARFTFDLPRAE

Sequences:

>Translated_442_residues
MIAANYQGYHQELSDLRLAFSRSGAVTGVVLVMLGVGLDYGLYPQHQVLFGVARFLVSLMMLTVMLGLPTRWGRPRVQAL
TLLWLVLPQLMIVWMIWYTDGAESLYYAGLNLAIFAVGIVMPLGFLQTVLFGAFTYIIWVIACVMHAGGIQSRGTFIVHS
LFILFSVVASAVYTYFNELGRFQLFQLKEELAEKNEQLEAINHSLTEIKGQLLQQEKMVAIGTLSAGLLHEINNPVNFCL
MAIAVAQEDSTAKASPMLLECLADAKEGMQRVQHIVSDLKTFAYRSPEKGVADTPFLAEKAIDSAIRLTSHELRGVEVNR
QLPPDTLVRGDEAAIIGVLINLLSNAALAMHKAQREHPCIDISAEWHNGRLYVVVKDNGPGIAEKNLSRVFEPFFTTREV
GKGLGLGLSISYSVIQHHGGTLSVASLEGEWARFTFDLPRAE
>Mature_442_residues
MIAANYQGYHQELSDLRLAFSRSGAVTGVVLVMLGVGLDYGLYPQHQVLFGVARFLVSLMMLTVMLGLPTRWGRPRVQAL
TLLWLVLPQLMIVWMIWYTDGAESLYYAGLNLAIFAVGIVMPLGFLQTVLFGAFTYIIWVIACVMHAGGIQSRGTFIVHS
LFILFSVVASAVYTYFNELGRFQLFQLKEELAEKNEQLEAINHSLTEIKGQLLQQEKMVAIGTLSAGLLHEINNPVNFCL
MAIAVAQEDSTAKASPMLLECLADAKEGMQRVQHIVSDLKTFAYRSPEKGVADTPFLAEKAIDSAIRLTSHELRGVEVNR
QLPPDTLVRGDEAAIIGVLINLLSNAALAMHKAQREHPCIDISAEWHNGRLYVVVKDNGPGIAEKNLSRVFEPFFTTREV
GKGLGLGLSISYSVIQHHGGTLSVASLEGEWARFTFDLPRAE

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=299, Percent_Identity=28.4280936454849, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=226, Percent_Identity=27.4336283185841, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786783, Length=249, Percent_Identity=27.3092369477912, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=25.3846153846154, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=26.2222222222222, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48806; Mature: 48806

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure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EEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]