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The map label for this gene is hoxA [H]

Identifier: 17547457

GI number: 17547457

Start: 2947354

End: 2948364

Strand: Direct

Name: hoxA [H]

Synonym: RSc2738

Alternate gene names: 17547457

Gene position: 2947354-2948364 (Clockwise)

Preceding gene: 17547456

Following gene: 17547466

Centisome position: 79.31

GC content: 67.56

Gene sequence:

>1011_bases
ATGACCAACCCCGGGGACAATGAGCCCAAGATCCTGTATGTGGACGACGAGACATTGGCGCTGACCTATTTCGGCCGTGC
CATCGGTTCACTGGCACCGGTCCTCACCGCCACCTCGGTCGAAGAAGGCAAGCGCATGCTCGACGAGCACGCCGCCACGC
TGGGCGTGCTGGTGTCGGACCAGCGCATGCCCGGCGAACTCGGCAACGAGCTGCTGCGCTACGCGCGCGAGCGCTATCCG
CACATGGTGCGTATCCTGACCACCGCCTACTCGGAAATCGAGGACACGGTGGAGGCGGTCAACCAGGGGCAGATCCACCG
CTACATCAAGAAGCCGTGGGACATCACCGCCCTGCGGGTCGAACTCAAGCAGGCGCTCGAGTTCGCCGACCTGCGCCGCG
AGCGCGACGCCCTGCTGCGCGAGAAGATGACGGTGCGGCAGAGCCAGACGCTAACCCATCGCATCGGTGCGCTGCAGACG
CTGTACCTAGCGGTGTCGGGGCTGTCGTCGTTCAGCGCAGTCAACGACTACCTGCGGGCCGCCGCGGCGGTCGGCCTGCA
CGCGCTGGAACAGCCCGACTGGACGCTGAAGGACTACACCGAACTGGTCGGCGAGGAAAGCCTGCGTACCGGCGAGTTCA
GCAACGCCGTCCGGCAGGCGTACCAGGACCTGTCGACGCGCTTCGACGCCAAACCGCCCGCGCAGGCGCTGGAAGTCCTG
GCGGAGGTGCTGCACGGCAAGGTCTCGCCGGCCGACGCAAGCGCGGCGGCGGTCGTGGATCTGGCGACGCTGACGGAATT
CCTGGAGGCATCGTCGACGCACCGCGTCTCGACGGCGCATGCCGAATGGCTGGCCTTCCTGCTCTGGCTGGACGGCAAGG
GCTGGTCGGTCACCGCCGAGCGCGATGGCGCCACCGTCAAGCTGCGCCTGGTCGACAACCAGTCCCAGCTCACCCCCGCC
CAGCTCGCCGCCTGGATGGAGCACTTCCAGGAGCAGCAGCAGGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGAGCGCAGGCACGCGCGTGACCCTGACGTTCCCATGAACCGAGCGATACCAGGCACCACGCCGTACCTGATCCGCGTT
TTTGCTAAGAGGAGTGATGG

Downstream 100 bases:

>100_bases
CCGGCCACCCCGCGGCGCCGGCGCTCAGGATGCGTCGGCGCTGCCGCTGTCGGGCGACGGGGCGGACTCGCCCGCCGGAC
GGTCGCGCATACCGCCCTTG

Product: response regulator transcription regulator protein

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTNPGDNEPKILYVDDETLALTYFGRAIGSLAPVLTATSVEEGKRMLDEHAATLGVLVSDQRMPGELGNELLRYARERYP
HMVRILTTAYSEIEDTVEAVNQGQIHRYIKKPWDITALRVELKQALEFADLRRERDALLREKMTVRQSQTLTHRIGALQT
LYLAVSGLSSFSAVNDYLRAAAAVGLHALEQPDWTLKDYTELVGEESLRTGEFSNAVRQAYQDLSTRFDAKPPAQALEVL
AEVLHGKVSPADASAAAVVDLATLTEFLEASSTHRVSTAHAEWLAFLLWLDGKGWSVTAERDGATVKLRLVDNQSQLTPA
QLAAWMEHFQEQQQAA

Sequences:

>Translated_336_residues
MTNPGDNEPKILYVDDETLALTYFGRAIGSLAPVLTATSVEEGKRMLDEHAATLGVLVSDQRMPGELGNELLRYARERYP
HMVRILTTAYSEIEDTVEAVNQGQIHRYIKKPWDITALRVELKQALEFADLRRERDALLREKMTVRQSQTLTHRIGALQT
LYLAVSGLSSFSAVNDYLRAAAAVGLHALEQPDWTLKDYTELVGEESLRTGEFSNAVRQAYQDLSTRFDAKPPAQALEVL
AEVLHGKVSPADASAAAVVDLATLTEFLEASSTHRVSTAHAEWLAFLLWLDGKGWSVTAERDGATVKLRLVDNQSQLTPA
QLAAWMEHFQEQQQAA
>Mature_335_residues
TNPGDNEPKILYVDDETLALTYFGRAIGSLAPVLTATSVEEGKRMLDEHAATLGVLVSDQRMPGELGNELLRYARERYPH
MVRILTTAYSEIEDTVEAVNQGQIHRYIKKPWDITALRVELKQALEFADLRRERDALLREKMTVRQSQTLTHRIGALQTL
YLAVSGLSSFSAVNDYLRAAAAVGLHALEQPDWTLKDYTELVGEESLRTGEFSNAVRQAYQDLSTRFDAKPPAQALEVLA
EVLHGKVSPADASAAAVVDLATLTEFLEASSTHRVSTAHAEWLAFLLWLDGKGWSVTAERDGATVKLRLVDNQSQLTPAQ
LAAWMEHFQEQQQAA

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 37331; Mature: 37199

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPGDNEPKILYVDDETLALTYFGRAIGSLAPVLTATSVEEGKRMLDEHAATLGVLVSD
CCCCCCCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
QRMPGELGNELLRYARERYPHMVRILTTAYSEIEDTVEAVNQGQIHRYIKKPWDITALRV
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
ELKQALEFADLRRERDALLREKMTVRQSQTLTHRIGALQTLYLAVSGLSSFSAVNDYLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAVGLHALEQPDWTLKDYTELVGEESLRTGEFSNAVRQAYQDLSTRFDAKPPAQALEVL
HHHHHHHHHCCCCCCHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AEVLHGKVSPADASAAAVVDLATLTEFLEASSTHRVSTAHAEWLAFLLWLDGKGWSVTAE
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCEEEEC
RDGATVKLRLVDNQSQLTPAQLAAWMEHFQEQQQAA
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNPGDNEPKILYVDDETLALTYFGRAIGSLAPVLTATSVEEGKRMLDEHAATLGVLVSD
CCCCCCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
QRMPGELGNELLRYARERYPHMVRILTTAYSEIEDTVEAVNQGQIHRYIKKPWDITALRV
CCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHH
ELKQALEFADLRRERDALLREKMTVRQSQTLTHRIGALQTLYLAVSGLSSFSAVNDYLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAAVGLHALEQPDWTLKDYTELVGEESLRTGEFSNAVRQAYQDLSTRFDAKPPAQALEVL
HHHHHHHHHCCCCCCHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AEVLHGKVSPADASAAAVVDLATLTEFLEASSTHRVSTAHAEWLAFLLWLDGKGWSVTAE
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEECCCCCEEEEC
RDGATVKLRLVDNQSQLTPAQLAAWMEHFQEQQQAA
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488 [H]