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The map label for this gene is pdhB [H]

Identifier: 17546517

GI number: 17546517

Start: 1933916

End: 1934896

Strand: Direct

Name: pdhB [H]

Synonym: RSc1798

Alternate gene names: 17546517

Gene position: 1933916-1934896 (Clockwise)

Preceding gene: 17546516

Following gene: 17546518

Centisome position: 52.04

GC content: 71.56

Gene sequence:

>981_bases
ATGGCTGACGTCAACCTGGTCGAGGCGGTCAACCTGGCGCTCGCGCATGCGCTGGAGCATGACCCGTCAGTGGTGCTGCT
GGGCGAGGACATCGGGGTCAACGGCGGGGTGTTCCGCGCCACGGTCGGGCTGCAGGCACGCTTCGGCGCCGAGCGCGTCA
TCGATACGCCGCTGGCCGAGACCGCGCTGGCCGGCGCCGCCATCGGCATGGCGGCGATGGGGCTGCGGCCGGTGGTCGAG
ATCCAGTTCAGCGGCTTCATCTATCCGGCCATCGACCACGTGCTCAATCACGCGGCCCGGCTGCGGCATCGCACGCGCGG
GCGGCTGTCGTGCCCGCTGGTGATCCGCTCGCCGTGCGGGGCCGGCATCCACGCGCCGGAGCACCATTCGGAGAGCCCGG
AGGCGCTGTTCGCGCACATGCCGGGGCTGCGGGTGGTGATTCCGTCGTCGCCGGCGCGGGCGTACGGGCTGCTGCTGGCG
GCCATCCGCGATCCGGACCCGGTGATCGTCTTCGAGCCGACGCGCCTGTACCGCGTGTTCCGCCAGCCGGTGGAGGACAA
CGGCGAGGCGCTGCCGCTGGACACCTGCTTCACCCTGCGCGACGGCACCGACGTGACGCTGGTGAGCTGGGGCGGAGCAT
TGCAGGCCGCGCAGGCCGCCGCCGACCAGCTCGCGCAGGACGGCGTGCTGGCCGAGGTGATCGACGTGGCCACGCTCAAG
CCGCTCGACATGGAAACCATCCTGGCCTCGGTGGCCAAGACCGGGCGCTGCGTGATCGTGCACGAGGCGCCGCGCACGTC
GGGCTTCGGTGCGGAGATCGCCGCCAACCTGGCCGAGCACGGGCTGTATTCGCTGCTGGCGCCTGTACAGCGGGTGACGG
GCTACGACGTGGTCATGCCGCTGCCCAGGCTGGAGAACCAATACCTGCCCGGCGTCGAGCGCATCCTCGCCGCGGTCAGG
AAGACCCTGGAGGCCGCCTGA

Upstream 100 bases:

>100_bases
TCGGCGATGTTCGACCACCTGTATGCCGCCTTGCCGCGCGCGCTGGAGGCGCAGCGCGCCATGGCGCTGGCCTTTGCGCC
GCAGGGCGGGGAGGGCGGCC

Downstream 100 bases:

>100_bases
CGATGATCGTCTTCAAACTGCCGGATCTCGGCGAAGGGCTGCAGGAGGCGGAGATCGTGCAATGGCACGTGCAGGCCGGC
GACACCGTCGAGGCCGATCA

Product: pyruvate decarboxylase E1 (Beta subunit) oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MADVNLVEAVNLALAHALEHDPSVVLLGEDIGVNGGVFRATVGLQARFGAERVIDTPLAETALAGAAIGMAAMGLRPVVE
IQFSGFIYPAIDHVLNHAARLRHRTRGRLSCPLVIRSPCGAGIHAPEHHSESPEALFAHMPGLRVVIPSSPARAYGLLLA
AIRDPDPVIVFEPTRLYRVFRQPVEDNGEALPLDTCFTLRDGTDVTLVSWGGALQAAQAAADQLAQDGVLAEVIDVATLK
PLDMETILASVAKTGRCVIVHEAPRTSGFGAEIAANLAEHGLYSLLAPVQRVTGYDVVMPLPRLENQYLPGVERILAAVR
KTLEAA

Sequences:

>Translated_326_residues
MADVNLVEAVNLALAHALEHDPSVVLLGEDIGVNGGVFRATVGLQARFGAERVIDTPLAETALAGAAIGMAAMGLRPVVE
IQFSGFIYPAIDHVLNHAARLRHRTRGRLSCPLVIRSPCGAGIHAPEHHSESPEALFAHMPGLRVVIPSSPARAYGLLLA
AIRDPDPVIVFEPTRLYRVFRQPVEDNGEALPLDTCFTLRDGTDVTLVSWGGALQAAQAAADQLAQDGVLAEVIDVATLK
PLDMETILASVAKTGRCVIVHEAPRTSGFGAEIAANLAEHGLYSLLAPVQRVTGYDVVMPLPRLENQYLPGVERILAAVR
KTLEAA
>Mature_325_residues
ADVNLVEAVNLALAHALEHDPSVVLLGEDIGVNGGVFRATVGLQARFGAERVIDTPLAETALAGAAIGMAAMGLRPVVEI
QFSGFIYPAIDHVLNHAARLRHRTRGRLSCPLVIRSPCGAGIHAPEHHSESPEALFAHMPGLRVVIPSSPARAYGLLLAA
IRDPDPVIVFEPTRLYRVFRQPVEDNGEALPLDTCFTLRDGTDVTLVSWGGALQAAQAAADQLAQDGVLAEVIDVATLKP
LDMETILASVAKTGRCVIVHEAPRTSGFGAEIAANLAEHGLYSLLAPVQRVTGYDVVMPLPRLENQYLPGVERILAAVRK
TLEAA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=43.8271604938272, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=43.8271604938272, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=39.1437308868502, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI291084858, Length=325, Percent_Identity=37.8461538461538, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI225637463, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI225637461, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI225637459, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=44.954128440367, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=39.5705521472393, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319698, Length=326, Percent_Identity=38.9570552147239, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI160714828, Length=323, Percent_Identity=45.2012383900929, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI160714832, Length=323, Percent_Identity=45.2012383900929, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21358145, Length=322, Percent_Identity=40.0621118012422, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24650940, Length=322, Percent_Identity=40.0621118012422, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24650943, Length=86, Percent_Identity=43.0232558139535, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24650945, Length=86, Percent_Identity=43.0232558139535, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34657; Mature: 34526

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVNLVEAVNLALAHALEHDPSVVLLGEDIGVNGGVFRATVGLQARFGAERVIDTPLAE
CCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHCCCHHHHCCCHHH
TALAGAAIGMAAMGLRPVVEIQFSGFIYPAIDHVLNHAARLRHRTRGRLSCPLVIRSPCG
HHHHHHHHHHHHHCCCEEEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
AGIHAPEHHSESPEALFAHMPGLRVVIPSSPARAYGLLLAAIRDPDPVIVFEPTRLYRVF
CCCCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHEECCCCCEEEECCHHHHHHH
RQPVEDNGEALPLDTCFTLRDGTDVTLVSWGGALQAAQAAADQLAQDGVLAEVIDVATLK
HCCCCCCCCEEECEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLDMETILASVAKTGRCVIVHEAPRTSGFGAEIAANLAEHGLYSLLAPVQRVTGYDVVMP
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
LPRLENQYLPGVERILAAVRKTLEAA
CCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADVNLVEAVNLALAHALEHDPSVVLLGEDIGVNGGVFRATVGLQARFGAERVIDTPLAE
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCHHHCCCHHHHCCCHHH
TALAGAAIGMAAMGLRPVVEIQFSGFIYPAIDHVLNHAARLRHRTRGRLSCPLVIRSPCG
HHHHHHHHHHHHHCCCEEEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCC
AGIHAPEHHSESPEALFAHMPGLRVVIPSSPARAYGLLLAAIRDPDPVIVFEPTRLYRVF
CCCCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHEECCCCCEEEECCHHHHHHH
RQPVEDNGEALPLDTCFTLRDGTDVTLVSWGGALQAAQAAADQLAQDGVLAEVIDVATLK
HCCCCCCCCEEECEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHCC
PLDMETILASVAKTGRCVIVHEAPRTSGFGAEIAANLAEHGLYSLLAPVQRVTGYDVVMP
CCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
LPRLENQYLPGVERILAAVRKTLEAA
CCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]