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The map label for this gene is pdhA [H]

Identifier: 17546516

GI number: 17546516

Start: 1932832

End: 1933923

Strand: Direct

Name: pdhA [H]

Synonym: RSc1797

Alternate gene names: 17546516

Gene position: 1932832-1933923 (Clockwise)

Preceding gene: 17546514

Following gene: 17546517

Centisome position: 52.01

GC content: 71.25

Gene sequence:

>1092_bases
ATGAGCACGGTCGGCAGCTTTCAGATCGACTACACGCAGTACCTTGACCCCGAGGGCCAGCCGGTCCAGCCATTGCCGGC
GTTTGCGCAAGACGTGCCGACCCTGCTCGCGCTGTATCGCGCCATGGTGCTGACGCGCGCGTTCGACACCAAGGCCATCG
CGCTGCAGCGCACCGGCAAGCTCGGCACCTTTGCCTCGTCGGTCGGCCAGGAGGCGATCGGCGTGGGCGTGGCCAGCGCC
ATGCGGGCCGAAGACGTCCTGTTCCCGTCCTACCGCGACCACAGCGCGCAGTTGCTGCGCGGCGTCAGCATGGCCGAGAG
CCTGCTGTACTGGGGCGGCGACGAGCGCGGCAGCTGCTTTGCTGCGGTGCGCGAAGATTTCCCGAACTGCGTGCCGATCG
GCACCCAGGTCTGCCACGCGGCGGGGGCCGCCTACGCGTTCCAGCTGCGCCGCGAGCCGCGTGTCGCCGTCGCGGTGTTC
GGTGACGGCGGCACCTCCAAGGGCGATTTCTATGAAGGGATGAACCTGGCCGGCGTGTGGGGCGCGCCGCTGGTGCTCAT
CGTCAACAACAACCAGTGGGCGATCTCGGTGCCGCGCAGCCGCCAGACCGCCGCGCAGACCCTGGCCCAGAAGGCGATCG
CCGCGGGTATCGCCGGGCGGCAGGTGGACGGCAACGACGTGATCGCCGTGCGGCAGGCCGCGCAGGACGCCCTCGACAAG
GCCCGCTCGGGCGGCGGCCCGACGCTGATCGAAGCGCTCAGCTACCGGCTGGGCGACCACACCACGGCGGACGACGCCAC
GCGCTACCGCGATCCGGACAGCGTCAAGCAGGCCTGGGCCCGCGAGCCGATCCTGCGCTTGCGCAACTACCTGATGCGCC
TGAGTGCCTGGGACAAGGCCCAGGAAGAGCAGCTCGGCCGCGCCTGCTATGCCCAGGTGGAGGAGGCGGTGGCGGCGTAC
CTGGCGGTCGGGCAGCCCGGCCCCTCGGCGATGTTCGACCACCTGTATGCCGCCTTGCCGCGCGCGCTGGAGGCGCAGCG
CGCCATGGCGCTGGCCTTTGCGCCGCAGGGCGGGGAGGGCGGCCATGGCTGA

Upstream 100 bases:

>100_bases
CCCGACTTGTTTTCGCCCGCGAAGCGTCTAGTGTTGAACCAGACGCGCGCGGGTGACGCCGCACGCGCCCCTTCCCAAGA
AGAACAAAGGGGCTGCAGTC

Downstream 100 bases:

>100_bases
CGTCAACCTGGTCGAGGCGGTCAACCTGGCGCTCGCGCATGCGCTGGAGCATGACCCGTCAGTGGTGCTGCTGGGCGAGG
ACATCGGGGTCAACGGCGGG

Product: pyruvate dehydrogenase E1 component alpha subunit oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSTVGSFQIDYTQYLDPEGQPVQPLPAFAQDVPTLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASA
MRAEDVLFPSYRDHSAQLLRGVSMAESLLYWGGDERGSCFAAVREDFPNCVPIGTQVCHAAGAAYAFQLRREPRVAVAVF
GDGGTSKGDFYEGMNLAGVWGAPLVLIVNNNQWAISVPRSRQTAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQDALDK
ARSGGGPTLIEALSYRLGDHTTADDATRYRDPDSVKQAWAREPILRLRNYLMRLSAWDKAQEEQLGRACYAQVEEAVAAY
LAVGQPGPSAMFDHLYAALPRALEAQRAMALAFAPQGGEGGHG

Sequences:

>Translated_363_residues
MSTVGSFQIDYTQYLDPEGQPVQPLPAFAQDVPTLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASA
MRAEDVLFPSYRDHSAQLLRGVSMAESLLYWGGDERGSCFAAVREDFPNCVPIGTQVCHAAGAAYAFQLRREPRVAVAVF
GDGGTSKGDFYEGMNLAGVWGAPLVLIVNNNQWAISVPRSRQTAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQDALDK
ARSGGGPTLIEALSYRLGDHTTADDATRYRDPDSVKQAWAREPILRLRNYLMRLSAWDKAQEEQLGRACYAQVEEAVAAY
LAVGQPGPSAMFDHLYAALPRALEAQRAMALAFAPQGGEGGHG
>Mature_362_residues
STVGSFQIDYTQYLDPEGQPVQPLPAFAQDVPTLLALYRAMVLTRAFDTKAIALQRTGKLGTFASSVGQEAIGVGVASAM
RAEDVLFPSYRDHSAQLLRGVSMAESLLYWGGDERGSCFAAVREDFPNCVPIGTQVCHAAGAAYAFQLRREPRVAVAVFG
DGGTSKGDFYEGMNLAGVWGAPLVLIVNNNQWAISVPRSRQTAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQDALDKA
RSGGGPTLIEALSYRLGDHTTADDATRYRDPDSVKQAWAREPILRLRNYLMRLSAWDKAQEEQLGRACYAQVEEAVAAYL
AVGQPGPSAMFDHLYAALPRALEAQRAMALAFAPQGGEGGHG

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=352, Percent_Identity=31.5340909090909, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI258645172, Length=352, Percent_Identity=31.5340909090909, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4885543, Length=348, Percent_Identity=26.4367816091954, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI291084742, Length=314, Percent_Identity=26.1146496815287, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4505685, Length=314, Percent_Identity=26.1146496815287, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI291084744, Length=321, Percent_Identity=25.5451713395639, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI291084757, Length=309, Percent_Identity=23.6245954692557, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563355, Length=334, Percent_Identity=32.9341317365269, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI86563357, Length=334, Percent_Identity=32.9341317365269, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17536047, Length=314, Percent_Identity=26.7515923566879, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32564172, Length=314, Percent_Identity=26.7515923566879, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6321026, Length=313, Percent_Identity=31.3099041533546, Blast_Score=146, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21355903, Length=324, Percent_Identity=29.9382716049383, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24639748, Length=308, Percent_Identity=29.8701298701299, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24639740, Length=312, Percent_Identity=27.2435897435897, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24639744, Length=312, Percent_Identity=27.2435897435897, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571106, Length=312, Percent_Identity=27.2435897435897, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24639746, Length=278, Percent_Identity=27.6978417266187, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38836; Mature: 38705

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVGSFQIDYTQYLDPEGQPVQPLPAFAQDVPTLLALYRAMVLTRAFDTKAIALQRTGK
CCCCCCEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCC
LGTFASSVGQEAIGVGVASAMRAEDVLFPSYRDHSAQLLRGVSMAESLLYWGGDERGSCF
CHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
AAVREDFPNCVPIGTQVCHAAGAAYAFQLRREPRVAVAVFGDGGTSKGDFYEGMNLAGVW
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHCCCCCCEEC
GAPLVLIVNNNQWAISVPRSRQTAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQDALDK
CCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ARSGGGPTLIEALSYRLGDHTTADDATRYRDPDSVKQAWAREPILRLRNYLMRLSAWDKA
HHCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCHH
QEEQLGRACYAQVEEAVAAYLAVGQPGPSAMFDHLYAALPRALEAQRAMALAFAPQGGEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
GHG
CCC
>Mature Secondary Structure 
STVGSFQIDYTQYLDPEGQPVQPLPAFAQDVPTLLALYRAMVLTRAFDTKAIALQRTGK
CCCCCEEECHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCC
LGTFASSVGQEAIGVGVASAMRAEDVLFPSYRDHSAQLLRGVSMAESLLYWGGDERGSCF
CHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHH
AAVREDFPNCVPIGTQVCHAAGAAYAFQLRREPRVAVAVFGDGGTSKGDFYEGMNLAGVW
HHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHCCCCCCEEC
GAPLVLIVNNNQWAISVPRSRQTAAQTLAQKAIAAGIAGRQVDGNDVIAVRQAAQDALDK
CCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ARSGGGPTLIEALSYRLGDHTTADDATRYRDPDSVKQAWAREPILRLRNYLMRLSAWDKA
HHCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHCHH
QEEQLGRACYAQVEEAVAAYLAVGQPGPSAMFDHLYAALPRALEAQRAMALAFAPQGGEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
GHG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]