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The map label for this gene is aceE [H]

Identifier: 17546319

GI number: 17546319

Start: 1717310

End: 1720000

Strand: Direct

Name: aceE [H]

Synonym: RSc1600

Alternate gene names: 17546319

Gene position: 1717310-1720000 (Clockwise)

Preceding gene: 17546313

Following gene: 17546320

Centisome position: 46.21

GC content: 64.51

Gene sequence:

>2691_bases
ATGTCGGCCGTACCAGAGCAAGTCCTGGGCGCCACGCGCGCCAGCGACGTCGATCCCCAGGAAACCAAGGAATGGCTGGA
GGCGCTGCAGGGCGTCATCGGCGCGGAAGGCCCGGACCGTGCAGCGTTCCTGCTCGACAAGCAGCTCGAGTACGCGCGCA
TCAACGGCGTGACCTCGCCGCTGCATGCGGAAACCCCCTATATCAATACGATCCCGGTCGAGAACCAGGAGCGCATTCCC
GGCGACCAGGAAATCGAGCACCGCATCCGCTCGTTCACGCGCTGGAACGCCATGGCGATGGTCCTGCGCGCCAACAAGGA
CACCAACGTCGGCGGCCACATCTCGTCGTTCGCCTCGGCCGCCACGCTGTATGACGTCGGCTACAACCATTTCTGGCATG
CCCCGTCGGACAAGCATGGCGGCGACATGGTCTTCGTGCAGGGTCACTCGGCACCGGGCGTGTATTCGCGCGCGTTCCTG
CTGGGCCGCCTGTCCGAAGATCAGCTCGACAGCTTCCGCCAGGAAGTGGACGGCAAGGGCATCTCGTCGTATCCGCACCC
GTGGCTGATGCCGGATTTCTGGCAGTTCCCGACCGTGTCGATGGGCCTGGGCCCGATCATGGCGATCTACCAGGCGCGCT
TCACCAAGTACCTGGCCAGCCGCAGCCTGATCCAGAACTTCGAGAACCGCAAGGTCTGGGCCTTCCTGGGCGACGGCGAG
ACCGACGAGCCGGAATCGCTGGGCGCGATCGGCATGGCCGGCCGCGAGAAGCTGGACAACCTGGTCTTCGTGATCAACTG
CAACCTGCAGCGCCTGGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAGCTGGAGAGCGAATTCCGCGGCGCCG
GCTGGAACGTCATCAAGGTCATCTGGGGCAGCCGCTGGGATCAACTGCTCGCCCGCGACACCAAGGGCCTGCTGATGAGC
CGCATGATGGAATGCGTCGACGGCGAGTACCAGACCTTCAAGTCGAAGAGCGGCGCCTATGTGCGTGAGTTCTTCTTCAA
CACGCCGGAACTCAAGGCCATGGTGGCCGACTGGTCCGACGACGACATCTGGGCGCTGAACCGCGGTGGTCATGACCCGC
ACAAGATCTTCGCCGCCTTCAAGTCGGCCACCGAGCACAAGGGCCAGCCGACCGTCATCCTCGCTAAGACCATCAAGGGC
TATGGCATGGGCGAGGCCGGCGAAGCGATGAACATCGCCCACCAGCAGAAGAAGATGCCGGTGGACGCCATCCGCAAGCT
GCGCGACCGCTTCAACATTCCGGTTGCCGACGATCAGCTCGAGCACGTTCCGTACGTCAAGTTCGAAGAAGGCTCGAAGG
AACTGGAATACATGCGCCGCGCGCGCATGGACCTGGGCGGCTACCTGCCGGCCCGCCGCCAGAAGGCCGACGCGCTGCAA
GTGCCGGCGCTGGCTGCGTTCGACGCGCTGCTCAAGGCCACTGGTGAAGGCCGCGAAGTGTCCACCACGATGGCCTTCGT
GCGCATTTTGAACATCCTGCTGAAGGACAAGAACGTCGGCAAGCACGTCGTGCCCATCGTCCCGGATGAGTCGCGCACGT
TCGGCATGGAAGGTCTGTTCCGCCAGGTCGGCATCTGGAACCAGGAAGGCCAGAAGTACGTGCCGCAGGACCACGACCAG
CTGATGTTCTACAAGGAATCGCAGACGGGTCAGGTGCTGCAGGAGGGCATCAACGAAGCCGGCGCCATGTGCGACTGGAT
CGCCGCCGCAACGTCGTACTCGACGCACGGCGTGGCGATGATCCCGTTCTACATCTACTACTCGATGTTCGGCATCCAGC
GCATCGGCGACCTCTGCTGGGCCGCCGGCGACATGCGCTCGCGCGGCTTCCTGCTGGGCGGCACCGCAGGCCGCACCACG
CTGAACGGCGAGGGTTTGCAGCACGAAGACGGCCACTCGCACGTCTACCACGCCGCCATCCCGAACTGCATCTCGTATGA
CCCGACCTTCCAGTATGAACTGGCGGTCGTGATGCAGGACGGCCTGCGCCGGATGTACGTCGAGCAGGAAGACGTCTATT
ACTACCTGACGGTGATGAACGAGAACTACGAGCACCCCGAAATGCCGGCGGGTGCCGAGGCCGACATCATCAAGGGCATG
TACCTGTTCAAGAAGGGCGTCGAGAACAGCAACGCGCCGCGCGTGCAACTGCTGGGCTCGGGCACGATCTTCCGCGAGGT
GATCGCCGCGGCCGAGCTGCTCAAGAAGGACTGGGGCGTCGAGTCCGATCTGTGGGGCTGCCCGAGCTTCACCGAGCTGG
CCCGCGAAGGCAATGCCGCAGCGCGCTGGAACCTGCTGCACCCGACCGACGCGCCGCGCGAATCGCACGTCGAGAAGATG
CTCAAGGGCGTGCGCGGCCCGGTCATTGCTTCGACCGACTACGTCCGCACCTTCGCCGAGCAGATCCGCGCCTTCGTGCC
GCGCCGCTACGTGGTGCTGGGCACCGACGGCTTCGGCCGCTCGGACACCCGCGAAAAGCTGCGCCACTTCTTCGAGGTGG
ATCGCTACTGGGTGACGGTCGCGTCGCTCAAGGCGCTCGCCGACGAAGGCGTGCTGCCGCGCGAAAAGGTGGCCGAGGCG
CTCAAGAAGTACAACCTCGATCCCAACAAGCCCAACCCGATGACCGTATAA

Upstream 100 bases:

>100_bases
GCAAAAGTCGGGCAGGCCTTGCTGCGCCGCGCGTTCGTGCAGCTTGCAAAAGGGCGCCCGCCTCAACAGACGCAACCCTT
ATTGCACCAAGGAGACCGCC

Downstream 100 bases:

>100_bases
CGGAGCCGCCGGGCGCGCTGCGTGCGTCCGGCCGGGCACCGGCCCCGCCAGGCTGCCTGCATAGTGCATTTGACGGCACG
ATGCGGTAGCCTGCCGGGCG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 896; Mature: 895

Protein sequence:

>896_residues
MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENQERIP
GDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFL
LGRLSEDQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGE
TDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDQLLARDTKGLLMS
RMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKG
YGMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQ
VPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQ
LMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTT
LNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGM
YLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPTDAPRESHVEKM
LKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEA
LKKYNLDPNKPNPMTV

Sequences:

>Translated_896_residues
MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENQERIP
GDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFL
LGRLSEDQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGE
TDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDQLLARDTKGLLMS
RMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKG
YGMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQ
VPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQ
LMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTT
LNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGM
YLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPTDAPRESHVEKM
LKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEA
LKKYNLDPNKPNPMTV
>Mature_895_residues
SAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENQERIPG
DQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLL
GRLSEDQLDSFRQEVDGKGISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGET
DEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKVIWGSRWDQLLARDTKGLLMSR
MMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSDDDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGY
GMGEAGEAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQV
PALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLFRQVGIWNQEGQKYVPQDHDQL
MFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAMIPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTL
NGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGMY
LFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAAARWNLLHPTDAPRESHVEKML
KGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEAL
KKYNLDPNKPNPMTV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=885, Percent_Identity=61.2429378531073, Blast_Score=1115, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100647; Mature: 100516

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSP
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
LHAETPYINTIPVENQERIPGDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASA
CCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHH
ATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGRLSEDQLDSFRQEVDGKG
HHHHHCCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
ISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
TDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKV
CCCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
IWGSRWDQLLARDTKGLLMSRMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSD
ECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCCHHEEEEECCCC
DDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKMP
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCC
VDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQ
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHCCCCHHC
VPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLF
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHH
RQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAM
HHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEEECCC
PNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGM
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHH
YLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAA
HHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCC
ARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGR
EEEEECCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVPEQVLGATRASDVDPQETKEWLEALQGVIGAEGPDRAAFLLDKQLEYARINGVTSP
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
LHAETPYINTIPVENQERIPGDQEIEHRIRSFTRWNAMAMVLRANKDTNVGGHISSFASA
CCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHH
ATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGRLSEDQLDSFRQEVDGKG
HHHHHCCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCC
ISSYPHPWLMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFENRKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
TDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVRGNGKIIQELESEFRGAGWNVIKV
CCCCHHCCCCCCCCHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEE
IWGSRWDQLLARDTKGLLMSRMMECVDGEYQTFKSKSGAYVREFFFNTPELKAMVADWSD
ECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHCCCCHHEEEEECCCC
DDIWALNRGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAGEAMNIAHQQKKMP
CCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCC
VDAIRKLRDRFNIPVADDQLEHVPYVKFEEGSKELEYMRRARMDLGGYLPARRQKADALQ
HHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCHHCCCCHHC
VPALAAFDALLKATGEGREVSTTMAFVRILNILLKDKNVGKHVVPIVPDESRTFGMEGLF
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHHHH
RQVGIWNQEGQKYVPQDHDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATSYSTHGVAM
HHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IPFYIYYSMFGIQRIGDLCWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEEECCC
PNCISYDPTFQYELAVVMQDGLRRMYVEQEDVYYYLTVMNENYEHPEMPAGAEADIIKGM
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHH
YLFKKGVENSNAPRVQLLGSGTIFREVIAAAELLKKDWGVESDLWGCPSFTELAREGNAA
HHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCC
ARWNLLHPTDAPRESHVEKMLKGVRGPVIASTDYVRTFAEQIRAFVPRRYVVLGTDGFGR
EEEEECCCCCCCHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCC
SDTREKLRHFFEVDRYWVTVASLKALADEGVLPREKVAEALKKYNLDPNKPNPMTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]