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The map label for this gene is parE [H]

Identifier: 17545695

GI number: 17545695

Start: 1024879

End: 1026864

Strand: Direct

Name: parE [H]

Synonym: RSc0976

Alternate gene names: 17545695

Gene position: 1024879-1026864 (Clockwise)

Preceding gene: 17545694

Following gene: 17545696

Centisome position: 27.58

GC content: 67.98

Gene sequence:

>1986_bases
ATGAGCAAAACTCCCCAATACAGCGAAGCGTCGATCAAGGTCCTGAAGGGCCTGGAACCGGTCAAGCAGCGGCCGGGCAT
GTACACGCGCACCGACAATCCGCTGCACATCGTGCAGGAAGTGATCGACAACGCCGCCGACGAAGCGCTGGGCGGCTACG
GCAAGTGGATCCAGGTGACGCTGCACAAGGACGGCAGCGTGAGCGTGGAAGACGAGGCGCGCGGCATTCCGGTCGGCATC
CATCCGGAAGAGGGCGTGCCGGTGGTGGAGATCGTCTTCACCCGGCTGCACGCGGGCGGCAAGTTCGACAAGGGGCGCGG
CGGCGCGTATGCGTTCTCCGGCGGCCTGCACGGCGTGGGCGTCTCGGTCACGAACGCGCTGTCGACGCGGCTGGAGGTGG
CGGTCTGGCGTGACGGCAGCGTCTCCACGCTGGCGTTCTCTGGCGGCGATGTCATCGAGGCGCTGGCCACCCGCCGCGCC
GAGCGCGGCGAGAAGAAGAACGGCACGCGCGTGCGTGTCTGGCCGGACGGCAAGTATTTCGATTCCGAGAACATCCCGCA
GGCCGAGCTGCAGCGGCTGCTGCGCAGCAAGGCGGTGCTGCTGCCGGGCGTGAAGGTGTCGCTCACGATCGAGAAGAGCG
GCGAGACGCTCGAATGGCAGTACGACCAGGGCCTGCGCGGCTACCTGATCGAATCGCTGGCGCAGGGCAGCGGCGCCGAC
CCGGTGATCCCGCTGTTCGAGGGCGAGCATTTCGCCGATCCCGACCGGCCCGGCGAAGAGGGCTTCGCCTTCGGCGAGGG
CGCATCGTGGGTGGTGGCCTGGACGGACGAGGGCTCGCCGGTGCGCGAGTCCTACGTCAACCTGATCCCGACGCCGGCCG
GCGGCACGCACGAGTCCGGTTTGCGCGAAGGCCTGTTCCAGGCGGTCAAGAGCTTCGTCGAGATGCACGCGCTGTGCCCC
AAGGGCGTCAAGCTGATGCCCGAAGACGTGTTCGCGCGCGCCTCGTTCGTGCTGTCGGCCAAGGTGCTCGATCCGCAGTT
CCAGGGCCAGATCAAGGAGCGCCTGAACAGCCGCGATGCGGTGCGGCTGGTGTCCACCTTCAGCCGCCCGGCGCTGGAGC
TGTGGCTGAACCAGCACGTCGAGTTCGGCAAGAAGCTGGCCGAACTGGTGATCCGCCAGGCTCAGGCCCGCACGCGCGCG
GCGCAGAAGGTCGAGAAGAAGAAGGGCTCCGGCGTGGCCGTGCTGCCCGGCAAGCTGACCGATTGCGAGTCGGACGATGT
CTCCCGCAACGAACTCTTCCTGGTGGAGGGCGATTCCGCCGGCGGCTCGGCCAAGATGGGCCGCGACAAGGAATTCCAGG
CCATCCTGCCGCTGCGCGGCAAGGTGCTCAACACGTGGGAGACCGAGCGCGACCGCCTGTTCGCCAACAACGAGGTGCAC
GACATCGCGGTGGCCATCGGGGTGGACCCGCACGGTCCGGCCGACAGCGTGGACCTGTCCGGCCTGCGCTACGGCAAGAT
CTGCATCCTGTCGGACGCCGACGTGGACGGCGCGCACATCCAGGTGCTGCTGCTGACGCTGTTCTTCAAGCATTTCCCGC
AACTGATCGGGCGCGGCAACGTGTGCGTGGCGCGGCCGCCGCTGTATCGCGTCGATGCGCCGGCGCGCGGCAAGAAGCCG
GCGCAGAAGCTCTACGCGCTGGACGACGGCGAGCTCGAGGCCATCGAAGACAAGCTGCGCAAGGAAGGCCTCAAGGAAGG
GTCCTGGCAGATCTCCCGCTTCAAGGGCCTGGGCGAGATGAGTGCCGAGCAGCTGTGGGAGACCACCATGAACCCCGACA
CGCGGCGCCTGCTGCCGGTTTCGATCGGCGAGCCCGGCGCGGAGCAGACTGTTCACGTGATGAACATGCTGATGGGCAAG
GGCGAGGCCGGCGCGCGCCGCACGTGGCTGGAGGCGCGCGGCAACGAGGTCGAGGCCGATATCTGA

Upstream 100 bases:

>100_bases
CGGCGGCGTCCACATTTCGTGTCACGTTGGCCGGGGCGGCTTCCTTTACAATGCGCGCTGCACTCCTGCCCGTCCGATGC
GGGCTGTTTTTCCGTCCTCC

Downstream 100 bases:

>100_bases
CCGATTGCGATGAAGCTGCTCCGACGCGCCGCGCTGCTCTGGATGGCCCTGGCCCTGCTGGCCGGCCAGCCGGCGCGCGC
CGACGTCTACGGCTACATCG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MSKTPQYSEASIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNAADEALGGYGKWIQVTLHKDGSVSVEDEARGIPVGI
HPEEGVPVVEIVFTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVAVWRDGSVSTLAFSGGDVIEALATRRA
ERGEKKNGTRVRVWPDGKYFDSENIPQAELQRLLRSKAVLLPGVKVSLTIEKSGETLEWQYDQGLRGYLIESLAQGSGAD
PVIPLFEGEHFADPDRPGEEGFAFGEGASWVVAWTDEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALCP
KGVKLMPEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEFGKKLAELVIRQAQARTRA
AQKVEKKKGSGVAVLPGKLTDCESDDVSRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
DIAVAIGVDPHGPADSVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIGRGNVCVARPPLYRVDAPARGKKP
AQKLYALDDGELEAIEDKLRKEGLKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVSIGEPGAEQTVHVMNMLMGK
GEAGARRTWLEARGNEVEADI

Sequences:

>Translated_661_residues
MSKTPQYSEASIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNAADEALGGYGKWIQVTLHKDGSVSVEDEARGIPVGI
HPEEGVPVVEIVFTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVAVWRDGSVSTLAFSGGDVIEALATRRA
ERGEKKNGTRVRVWPDGKYFDSENIPQAELQRLLRSKAVLLPGVKVSLTIEKSGETLEWQYDQGLRGYLIESLAQGSGAD
PVIPLFEGEHFADPDRPGEEGFAFGEGASWVVAWTDEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALCP
KGVKLMPEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEFGKKLAELVIRQAQARTRA
AQKVEKKKGSGVAVLPGKLTDCESDDVSRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
DIAVAIGVDPHGPADSVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIGRGNVCVARPPLYRVDAPARGKKP
AQKLYALDDGELEAIEDKLRKEGLKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVSIGEPGAEQTVHVMNMLMGK
GEAGARRTWLEARGNEVEADI
>Mature_660_residues
SKTPQYSEASIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNAADEALGGYGKWIQVTLHKDGSVSVEDEARGIPVGIH
PEEGVPVVEIVFTRLHAGGKFDKGRGGAYAFSGGLHGVGVSVTNALSTRLEVAVWRDGSVSTLAFSGGDVIEALATRRAE
RGEKKNGTRVRVWPDGKYFDSENIPQAELQRLLRSKAVLLPGVKVSLTIEKSGETLEWQYDQGLRGYLIESLAQGSGADP
VIPLFEGEHFADPDRPGEEGFAFGEGASWVVAWTDEGSPVRESYVNLIPTPAGGTHESGLREGLFQAVKSFVEMHALCPK
GVKLMPEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNQHVEFGKKLAELVIRQAQARTRAA
QKVEKKKGSGVAVLPGKLTDCESDDVSRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVHD
IAVAIGVDPHGPADSVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIGRGNVCVARPPLYRVDAPARGKKPA
QKLYALDDGELEAIEDKLRKEGLKEGSWQISRFKGLGEMSAEQLWETTMNPDTRRLLPVSIGEPGAEQTVHVMNMLMGKG
EAGARRTWLEARGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=647, Percent_Identity=23.4930448222566, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI19913406, Length=666, Percent_Identity=23.2732732732733, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1789408, Length=660, Percent_Identity=49.0909090909091, Blast_Score=610, Evalue=1e-175,
Organism=Escherichia coli, GI48994957, Length=593, Percent_Identity=37.9426644182125, Blast_Score=345, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI17535065, Length=653, Percent_Identity=23.7366003062787, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI212645845, Length=639, Percent_Identity=23.7871674491393, Blast_Score=106, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324241, Length=642, Percent_Identity=23.98753894081, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=24.1641337386018, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 72205; Mature: 72074

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTPQYSEASIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNAADEALGGYGKWIQVT
CCCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LHKDGSVSVEDEARGIPVGIHPEEGVPVVEIVFTRLHAGGKFDKGRGGAYAFSGGLHGVG
EECCCCEEECCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
VSVTNALSTRLEVAVWRDGSVSTLAFSGGDVIEALATRRAERGEKKNGTRVRVWPDGKYF
HHHHHHHHCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
DSENIPQAELQRLLRSKAVLLPGVKVSLTIEKSGETLEWQYDQGLRGYLIESLAQGSGAD
CCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCC
PVIPLFEGEHFADPDRPGEEGFAFGEGASWVVAWTDEGSPVRESYVNLIPTPAGGTHESG
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHH
LREGLFQAVKSFVEMHALCPKGVKLMPEDVFARASFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHH
VRLVSTFSRPALELWLNQHVEFGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGKLT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DCESDDVSRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DIAVAIGVDPHGPADSVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIGRGN
EEEEEEECCCCCCCCCCCCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VCVARPPLYRVDAPARGKKPAQKLYALDDGELEAIEDKLRKEGLKEGSWQISRFKGLGEM
EEEECCCCEECCCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEHHHHCCCCHH
SAEQLWETTMNPDTRRLLPVSIGEPGAEQTVHVMNMLMGKGEAGARRTWLEARGNEVEAD
HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
I
C
>Mature Secondary Structure 
SKTPQYSEASIKVLKGLEPVKQRPGMYTRTDNPLHIVQEVIDNAADEALGGYGKWIQVT
CCCCCCCHHHHHHHHCCCHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
LHKDGSVSVEDEARGIPVGIHPEEGVPVVEIVFTRLHAGGKFDKGRGGAYAFSGGLHGVG
EECCCCEEECCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
VSVTNALSTRLEVAVWRDGSVSTLAFSGGDVIEALATRRAERGEKKNGTRVRVWPDGKYF
HHHHHHHHCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCC
DSENIPQAELQRLLRSKAVLLPGVKVSLTIEKSGETLEWQYDQGLRGYLIESLAQGSGAD
CCCCCCHHHHHHHHHHCCEECCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCC
PVIPLFEGEHFADPDRPGEEGFAFGEGASWVVAWTDEGSPVRESYVNLIPTPAGGTHESG
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEECCCCCHHHHHHHHEECCCCCCCCHHH
LREGLFQAVKSFVEMHALCPKGVKLMPEDVFARASFVLSAKVLDPQFQGQIKERLNSRDA
HHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEEECCCHHHHHHHHHHCCCHHH
VRLVSTFSRPALELWLNQHVEFGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGKLT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
DCESDDVSRNELFLVEGDSAGGSAKMGRDKEFQAILPLRGKVLNTWETERDRLFANNEVH
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCHHHEECCCCEE
DIAVAIGVDPHGPADSVDLSGLRYGKICILSDADVDGAHIQVLLLTLFFKHFPQLIGRGN
EEEEEEECCCCCCCCCCCCCCEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VCVARPPLYRVDAPARGKKPAQKLYALDDGELEAIEDKLRKEGLKEGSWQISRFKGLGEM
EEEECCCCEECCCCCCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCCEEHHHHCCCCHH
SAEQLWETTMNPDTRRLLPVSIGEPGAEQTVHVMNMLMGKGEAGARRTWLEARGNEVEAD
HHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]