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The map label for this gene is pheA [H]

Identifier: 17545623

GI number: 17545623

Start: 955128

End: 956243

Strand: Direct

Name: pheA [H]

Synonym: RSc0904

Alternate gene names: 17545623

Gene position: 955128-956243 (Clockwise)

Preceding gene: 17545622

Following gene: 17545624

Centisome position: 25.7

GC content: 68.28

Gene sequence:

>1116_bases
ATGACCAGTCAGTCAGACGAAACGAGTCAAAACAAGGACGCCGCATTGGCGGCGGAGCTGGCACCCCTGCGCGCGCAGAT
CGATGCCATCGACAGCCAACTGCTCACCCTGCTGTCGGACCGCGCCAAGGTGGCGCAGGCCGTGGGCGAGGTGAAGAAGC
ACTATGCGTCGCCGGCATTCCGGCCGGACCGCGAGCTGCAGGTCATCCGCAAGATGCAGTCGGGCAATCCGGGGCCGCTG
CACGGCGAGAGCATCGCGGCCATCTGGCGCGAGGTGATGTCGGCATGCCGGGGCCTGGAGCAGGCGCTGCGCATTGGCTA
TCTCGGCCCGGTGGGCACGTTCACGGAGCAAGCCGTGTTCGCGCACTTCGGCCACGAGATCCAGCCGATGCCGTGCCCGA
GTATCGACGAGGTGTTCCGCGCGGCAGAGGCCGGCACGGTCGATTGCGGTGTGGTGCCGGTCGAGAATTCGACCGAGGGC
GTGGTGTCGCGCACGCTCGATCTGTTCTTGCAGACGTCGCTGAAGATCAGCGGCGAGATCGCGCTGCGGGTGCACCACAA
CCTGCTGCACAAGACCGGCGACATGTCGCAGGTGAAGGTGGTGCGGGCGCATGCGCAGGCGCTGGCGCAGTGCCAGCGCT
GGCTCAACACGAACTACCCGAACCTGGCGCGCGAGGCGGTGTCGAGCAACGCCGAGGCCGCGCGCATGGCCGGCGAAGAC
GAGACCGTCGCCGCGCTGGCGAGCGTGCAGGCGGCCAACCGCTATGGGCTGCACGTGGTGCGGGCCAACGTGGAGGACGA
CCCGCACAACCGCACACGCTTCGTGGTGATCGGCAACTACGAGACCGAGCCGAGCGGGCGCGACCAGACCTCGCTGATCC
TCTCGGTGCCGAATGAGGCCGGGGCGGTCTACCGGCTGCTGGCGCCGCTCGCCGAGAACGGCGTGTCGATGTGCCGCTTC
GAGTCGCGGCCGGCGCGCAGCGGCGCGTGGGAGTACTACTTCTACGTCGACGTGGAAGGCCACCAGCGCGACCCGCAGGT
GGCGCGCGCGCTGGAGAAGCTGCGCCACGACGCCGCGTATTTCAAAGTGCTGGGGTCCTATCCCTCGGCACACTGA

Upstream 100 bases:

>100_bases
ACCGCCGCCTGAGCCGCGCGCCGCAATCACGGCAGAACATTGCGCAAAGCCCCTGCTTTGCGCGGCAATTAGCAATCTGT
TGCCGAACCCGATCTCTACA

Downstream 100 bases:

>100_bases
GGGATTCAGAAAGAAGCGCCCCGCACGGGCGGGGCGCCGATACCAGAGGAGCAGCCCCATGTCGTTGCAGTTCGGCCCCG
AATATGTCCGTGCCATTGCC

Product: bifunctional chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTSQSDETSQNKDAALAAELAPLRAQIDAIDSQLLTLLSDRAKVAQAVGEVKKHYASPAFRPDRELQVIRKMQSGNPGPL
HGESIAAIWREVMSACRGLEQALRIGYLGPVGTFTEQAVFAHFGHEIQPMPCPSIDEVFRAAEAGTVDCGVVPVENSTEG
VVSRTLDLFLQTSLKISGEIALRVHHNLLHKTGDMSQVKVVRAHAQALAQCQRWLNTNYPNLAREAVSSNAEAARMAGED
ETVAALASVQAANRYGLHVVRANVEDDPHNRTRFVVIGNYETEPSGRDQTSLILSVPNEAGAVYRLLAPLAENGVSMCRF
ESRPARSGAWEYYFYVDVEGHQRDPQVARALEKLRHDAAYFKVLGSYPSAH

Sequences:

>Translated_371_residues
MTSQSDETSQNKDAALAAELAPLRAQIDAIDSQLLTLLSDRAKVAQAVGEVKKHYASPAFRPDRELQVIRKMQSGNPGPL
HGESIAAIWREVMSACRGLEQALRIGYLGPVGTFTEQAVFAHFGHEIQPMPCPSIDEVFRAAEAGTVDCGVVPVENSTEG
VVSRTLDLFLQTSLKISGEIALRVHHNLLHKTGDMSQVKVVRAHAQALAQCQRWLNTNYPNLAREAVSSNAEAARMAGED
ETVAALASVQAANRYGLHVVRANVEDDPHNRTRFVVIGNYETEPSGRDQTSLILSVPNEAGAVYRLLAPLAENGVSMCRF
ESRPARSGAWEYYFYVDVEGHQRDPQVARALEKLRHDAAYFKVLGSYPSAH
>Mature_370_residues
TSQSDETSQNKDAALAAELAPLRAQIDAIDSQLLTLLSDRAKVAQAVGEVKKHYASPAFRPDRELQVIRKMQSGNPGPLH
GESIAAIWREVMSACRGLEQALRIGYLGPVGTFTEQAVFAHFGHEIQPMPCPSIDEVFRAAEAGTVDCGVVPVENSTEGV
VSRTLDLFLQTSLKISGEIALRVHHNLLHKTGDMSQVKVVRAHAQALAQCQRWLNTNYPNLAREAVSSNAEAARMAGEDE
TVAALASVQAANRYGLHVVRANVEDDPHNRTRFVVIGNYETEPSGRDQTSLILSVPNEAGAVYRLLAPLAENGVSMCRFE
SRPARSGAWEYYFYVDVEGHQRDPQVARALEKLRHDAAYFKVLGSYPSAH

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=373, Percent_Identity=31.3672922252011, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 40608; Mature: 40477

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00857 PREPHENATE_DEHYDR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQSDETSQNKDAALAAELAPLRAQIDAIDSQLLTLLSDRAKVAQAVGEVKKHYASPAF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPDRELQVIRKMQSGNPGPLHGESIAAIWREVMSACRGLEQALRIGYLGPVGTFTEQAVF
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AHFGHEIQPMPCPSIDEVFRAAEAGTVDCGVVPVENSTEGVVSRTLDLFLQTSLKISGEI
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHEECCEE
ALRVHHNLLHKTGDMSQVKVVRAHAQALAQCQRWLNTNYPNLAREAVSSNAEAARMAGED
EEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCC
ETVAALASVQAANRYGLHVVRANVEDDPHNRTRFVVIGNYETEPSGRDQTSLILSVPNEA
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCH
GAVYRLLAPLAENGVSMCRFESRPARSGAWEYYFYVDVEGHQRDPQVARALEKLRHDAAY
HHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
FKVLGSYPSAH
HHHHCCCCCCC
>Mature Secondary Structure 
TSQSDETSQNKDAALAAELAPLRAQIDAIDSQLLTLLSDRAKVAQAVGEVKKHYASPAF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPDRELQVIRKMQSGNPGPLHGESIAAIWREVMSACRGLEQALRIGYLGPVGTFTEQAVF
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AHFGHEIQPMPCPSIDEVFRAAEAGTVDCGVVPVENSTEGVVSRTLDLFLQTSLKISGEI
HHCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHEECCEE
ALRVHHNLLHKTGDMSQVKVVRAHAQALAQCQRWLNTNYPNLAREAVSSNAEAARMAGED
EEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCC
ETVAALASVQAANRYGLHVVRANVEDDPHNRTRFVVIGNYETEPSGRDQTSLILSVPNEA
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCH
GAVYRLLAPLAENGVSMCRFESRPARSGAWEYYFYVDVEGHQRDPQVARALEKLRHDAAY
HHHHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHH
FKVLGSYPSAH
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10094619 [H]