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The map label for this gene is hisC2

Identifier: 17545624

GI number: 17545624

Start: 956302

End: 957426

Strand: Direct

Name: hisC2

Synonym: RSc0905

Alternate gene names: 17545624

Gene position: 956302-957426 (Clockwise)

Preceding gene: 17545623

Following gene: 17545625

Centisome position: 25.73

GC content: 68.18

Gene sequence:

>1125_bases
ATGTCGTTGCAGTTCGGCCCCGAATATGTCCGTGCCATTGCCCCCTATGTGACCGGCAAGCCGATTTCCGAAGTCGCGCG
CGAGTTCGGTCTGGAGGCGGCGCGCATCGTCAAGCTGGCGTCCAACGAGAACCCGCTGGGCATGCCGGCATCGGCCAGGG
TGGCAATGACGGCTGCCATCGATGGGCTGGCGCGCTATCCGGACGCCAACGGTTTCAGCCTGAAGGCCGCGCTGCACGCG
AAGTTCGGCGTGCCGGAGGCCTGGATCACGCTCGGCAACGGCAGCAACGACATCCTCGAACTCGCTGCGCGCGCCCTGGT
GGCACCGGGGCAAGGCGTGATCTACGCGCAGCATGCGTTTGCCGTGTATGCGCTGGCGGCGCAGGAGGTCGGTGCACGGG
CCGTCGAGGTGCCGGCCCGCGACTATGGCCACGATCTGGACGCGATGGCCGCCGCCATCACGCCGGACACGCGCCTGATC
TACGTCGCCAACCCGAACAATCCGACCGGCACCTTCCTGCCGGCCGACGCGGTCGCTGCGTTCCTGGCCAAGGTGCCGCC
GACGGTCGTCGTCGTGCTGGACGAGGCGTACAACGAATTCCTCAAGCCCGAGCAACAGTACGACTCGATCGCGTGGGTGC
GTCGGTATCCGAACCTGCTGGTGTCGCGCACGTTCTCCAAGGCCTACGGGCTGGCCGGCCTGCGTGTCGGCTACGGCATC
GCGCAGCCGCAGCTGACGGCGCTACTCAATCGGATCCGCCAGCCGTTCAACGTCAACAGCCTCGCGCAGGCCGCAGCTGT
CGCCGCGCTGAGCGACACCGAATTCCTGCGCAGATCGGCCGAACTGAACGCCGCGGGCTATGCGCAGCTGACGCAGGCGT
TTGCGCGCCTCGGGCTGGAATACGTGCCGTCGTCGGGTAACTTCGTGCTGGTCCGTGTCGGCGACGATGCGGATGCGGGC
GCGCGCGTCAATCTGGCGCTGCTCAGGCAGGGCGTGATCGTGCGGCCGGTGGGCAACTATGGCCTGCCGCAGTGGCTGCG
CATCAGCATCGGGCTGCCGGAGGAGAATGCCGCCTGCATCGCTGCGCTGGAGTCGGCGCTGGCGCAGGCCGAGGCCGCCG
CCTGA

Upstream 100 bases:

>100_bases
GCGTATTTCAAAGTGCTGGGGTCCTATCCCTCGGCACACTGAGGGATTCAGAAAGAAGCGCCCCGCACGGGCGGGGCGCC
GATACCAGAGGAGCAGCCCC

Downstream 100 bases:

>100_bases
CCGGCAGCGCGTCGCACGGCGGTCGCGGCCGGCACATCGGGCGCGACGCACATCGGGCTACAATGCCGCTTTGCTTTTTT
CTGGCAGGGCAGTGTTGTGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSLQFGPEYVRAIAPYVTGKPISEVAREFGLEAARIVKLASNENPLGMPASARVAMTAAIDGLARYPDANGFSLKAALHA
KFGVPEAWITLGNGSNDILELAARALVAPGQGVIYAQHAFAVYALAAQEVGARAVEVPARDYGHDLDAMAAAITPDTRLI
YVANPNNPTGTFLPADAVAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSIAWVRRYPNLLVSRTFSKAYGLAGLRVGYGI
AQPQLTALLNRIRQPFNVNSLAQAAAVAALSDTEFLRRSAELNAAGYAQLTQAFARLGLEYVPSSGNFVLVRVGDDADAG
ARVNLALLRQGVIVRPVGNYGLPQWLRISIGLPEENAACIAALESALAQAEAAA

Sequences:

>Translated_374_residues
MSLQFGPEYVRAIAPYVTGKPISEVAREFGLEAARIVKLASNENPLGMPASARVAMTAAIDGLARYPDANGFSLKAALHA
KFGVPEAWITLGNGSNDILELAARALVAPGQGVIYAQHAFAVYALAAQEVGARAVEVPARDYGHDLDAMAAAITPDTRLI
YVANPNNPTGTFLPADAVAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSIAWVRRYPNLLVSRTFSKAYGLAGLRVGYGI
AQPQLTALLNRIRQPFNVNSLAQAAAVAALSDTEFLRRSAELNAAGYAQLTQAFARLGLEYVPSSGNFVLVRVGDDADAG
ARVNLALLRQGVIVRPVGNYGLPQWLRISIGLPEENAACIAALESALAQAEAAA
>Mature_373_residues
SLQFGPEYVRAIAPYVTGKPISEVAREFGLEAARIVKLASNENPLGMPASARVAMTAAIDGLARYPDANGFSLKAALHAK
FGVPEAWITLGNGSNDILELAARALVAPGQGVIYAQHAFAVYALAAQEVGARAVEVPARDYGHDLDAMAAAITPDTRLIY
VANPNNPTGTFLPADAVAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSIAWVRRYPNLLVSRTFSKAYGLAGLRVGYGIA
QPQLTALLNRIRQPFNVNSLAQAAAVAALSDTEFLRRSAELNAAGYAQLTQAFARLGLEYVPSSGNFVLVRVGDDADAGA
RVNLALLRQGVIVRPVGNYGLPQWLRISIGLPEENAACIAALESALAQAEAAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=363, Percent_Identity=28.099173553719, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788627, Length=241, Percent_Identity=26.1410788381743, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=360, Percent_Identity=27.2222222222222, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_RALSO (Q8Y0Y8)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519026.1
- ProteinModelPortal:   Q8Y0Y8
- SMR:   Q8Y0Y8
- GeneID:   1219713
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0905
- NMPDR:   fig|267608.1.peg.905
- HOGENOM:   HBG646350
- OMA:   QWLRISI
- ProtClustDB:   PRK02731
- BioCyc:   RSOL267608:RSC0905-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39628; Mature: 39496

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQFGPEYVRAIAPYVTGKPISEVAREFGLEAARIVKLASNENPLGMPASARVAMTAAI
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHEEHHHHH
DGLARYPDANGFSLKAALHAKFGVPEAWITLGNGSNDILELAARALVAPGQGVIYAQHAF
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEHHHH
AVYALAAQEVGARAVEVPARDYGHDLDAMAAAITPDTRLIYVANPNNPTGTFLPADAVAA
HHHHHHHHHHCCCEEECCCHHHCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCHHHHHH
FLAKVPPTVVVVLDEAYNEFLKPEQQYDSIAWVRRYPNLLVSRTFSKAYGLAGLRVGYGI
HHHHCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCC
AQPQLTALLNRIRQPFNVNSLAQAAAVAALSDTEFLRRSAELNAAGYAQLTQAFARLGLE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCE
YVPSSGNFVLVRVGDDADAGARVNLALLRQGVIVRPVGNYGLPQWLRISIGLPEENAACI
EECCCCCEEEEEECCCCCCCCEEEHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHH
AALESALAQAEAAA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SLQFGPEYVRAIAPYVTGKPISEVAREFGLEAARIVKLASNENPLGMPASARVAMTAAI
CCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHEEHHHHH
DGLARYPDANGFSLKAALHAKFGVPEAWITLGNGSNDILELAARALVAPGQGVIYAQHAF
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEHHHH
AVYALAAQEVGARAVEVPARDYGHDLDAMAAAITPDTRLIYVANPNNPTGTFLPADAVAA
HHHHHHHHHHCCCEEECCCHHHCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCHHHHHH
FLAKVPPTVVVVLDEAYNEFLKPEQQYDSIAWVRRYPNLLVSRTFSKAYGLAGLRVGYGI
HHHHCCCEEEEEEEHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHCCCC
AQPQLTALLNRIRQPFNVNSLAQAAAVAALSDTEFLRRSAELNAAGYAQLTQAFARLGLE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCE
YVPSSGNFVLVRVGDDADAGARVNLALLRQGVIVRPVGNYGLPQWLRISIGLPEENAACI
EECCCCCEEEEEECCCCCCCCEEEHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHH
AALESALAQAEAAA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852