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The map label for this gene is fabZ

Identifier: 218928223

GI number: 218928223

Start: 1197598

End: 1198143

Strand: Direct

Name: fabZ

Synonym: YPO1055

Alternate gene names: 218928223

Gene position: 1197598-1198143 (Clockwise)

Preceding gene: 218928222

Following gene: 218928224

Centisome position: 25.73

GC content: 47.07

Gene sequence:

>546_bases
TTGACTACTGACACTCATACTCTGCATATTGAAGAGATTTTGGATCTACTCCCGCACCGTTTTCCGTTCTTGCTGGTAGA
CCGTGTCCTTGATTTTGAGGAAGGAAAATTTCTGCGTGCAGTGAAGAACGTCTCTTTTAACGAGCCATTTTTCCAAGGCC
ATTTCCCAGGCAAGCCCATCTTCCCTGGTGTGCTTATATTAGAAGCGATGGCGCAGGCTACAGGGATTTTGGCGTTTAAG
AGCCGCGGTAAACTGGAACCGGGCGAGCTTTATTACTTTGCTGGTATTGATGAAGCACGTTTTAAGCGCCCAGTAGTGCC
TGGCGATCAGATGATCATGGAAGTTGAGTTTGTTAAAGAACGCCGTGGCCTAACCCGTTTTACCGGTGTAGCTAAAGTCG
ATGGCGAAATCGTTTGCACTGCCACCATGATGTGCGCGCGTAGCAAACCAGCAGCACCTGCAGAATCTGTCGTTGTAAAA
CCAGATGTTGTAAAACCAGATGTTGTAAAACCAGATGTTGTAAATCCTGTCGTTAAGGAGTCCTGA

Upstream 100 bases:

>100_bases
GTCTACAGAGTTCCTAATTTGCGGCCTGCCTAATGCCTCCCTTTGGGGCTGTGCAGGCCGTGTTGTTGATAGCATCAGTT
TTTTAGACAGGAAGAGTATT

Downstream 100 bases:

>100_bases
TTCGTGATTGACAAAACCGCCTTTATCCATCCAAGTTCTATCGTTGAAGAAGGTGCCATCATTGGCGCTGGTGTTTATAT
TGGGCCCTTCTGCATTGTCG

Product: (3R)-hydroxymyristoyl-ACP dehydratase

Products: NA

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFK
SRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKERRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVK
PDVVKPDVVKPDVVNPVVKES

Sequences:

>Translated_181_residues
MTTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFK
SRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKERRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVK
PDVVKPDVVKPDVVNPVVKES
>Mature_180_residues
TTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKS
RGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKERRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVKP
DVVKPDVVKPDVVNPVVKES

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=151, Percent_Identity=89.4039735099338, Blast_Score=278, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_YERPE (Q8ZH57)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AF0129
- RefSeq:   NP_670423.1
- RefSeq:   NP_994102.1
- RefSeq:   YP_002346098.1
- ProteinModelPortal:   Q8ZH57
- SMR:   Q8ZH57
- GeneID:   1148071
- GeneID:   1173895
- GeneID:   2765658
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1055
- KEGG:   ypk:y3124
- KEGG:   ypm:YP_2795
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- ProtClustDB:   PRK00006
- BioCyc:   YPES187410:Y3124-MONOMER
- BioCyc:   YPES214092:YPO1055-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.-

Molecular weight: Translated: 20170; Mature: 20039

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 54-54

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPI
CCCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
FPGVLILEAMAQATGILAFKSRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKE
CHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHH
RRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVKPDVVKPDVVKPDVVNPVVKE
HCCCHHHCCEEECCCCEEEHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHCC
S
C
>Mature Secondary Structure 
TTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPI
CCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
FPGVLILEAMAQATGILAFKSRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKE
CHHHHHHHHHHHHHHEEEECCCCCCCCCCEEEEECCCHHHHCCCCCCCHHHHHHHHHHHH
RRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVKPDVVKPDVVKPDVVNPVVKE
HCCCHHHCCEEECCCCEEEHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430