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The map label for this gene is lpxA [H]

Identifier: 218928224

GI number: 218928224

Start: 1198147

End: 1198935

Strand: Direct

Name: lpxA [H]

Synonym: YPO1056

Alternate gene names: 218928224

Gene position: 1198147-1198935 (Clockwise)

Preceding gene: 218928223

Following gene: 218928225

Centisome position: 25.75

GC content: 47.02

Gene sequence:

>789_bases
GTGATTGACAAAACCGCCTTTATCCATCCAAGTTCTATCGTTGAAGAAGGTGCCATCATTGGCGCTGGTGTTTATATTGG
GCCCTTCTGCATTGTCGGATCCCAGGTGGAAATTGGTGCTGGCACGGAACTGAAATCCCACGTTGTCGTTAATGGCATAA
CCAAGATCGGCTGTGATAATCAAATTTACCAGTTTGCTTCCATCGGTGAAGCGAACCAAGATCTGAAATATGCAGGTGAG
CCTACTCGGGTTGAGGTCGGTGATCGTAACCGTATACGTGAAAGTGTCACTATCCACCGAGGTACCACACAAGGTGGGGG
GGTGACCAAGGTCGGTTGCGACAATCTACTGATGGTTAATACCCATGTTGCCCATGATTGTGTCATTGGTAACCGTTGCA
TTCTTGCTAATAATGCTGCGTTGGGGGGTCATGTAGAGATTGACGATTACGCTATTATCGGTGGCATGACGGCTATCCAT
CAATTTTGTGTGATTGGTGCGCATGTGATGGTCGGCGGTTGTTCCGGTATTACTCAGGATGTGCCTCCTTTTGTCATCGC
TCAAGGGAATCATGCGACGCCATTTGGGATTAATATTGAAGGTTTGAAACGTCGTGGTTTCGACAAAGAATCTCTTCATG
CTATCCGTAGTGCATACAAGTTGTTGTACCGCAGTGGCAGGACGTTGGATGAAGTGAAACCAGAAATTGCTGAATTAGCG
GAGCAATATCCAGTCGTTAAAGCGTTCAATGATTTCTTTGCTCGTTCGACCCGCGGTATTATTCGCTGA

Upstream 100 bases:

>100_bases
AGCAGCACCTGCAGAATCTGTCGTTGTAAAACCAGATGTTGTAAAACCAGATGTTGTAAAACCAGATGTTGTAAATCCTG
TCGTTAAGGAGTCCTGATTC

Downstream 100 bases:

>100_bases
CTTATGCAAAATAGCCCATTGACTGCTGATTGTTCATTAAACGCTGGACGTCCCCTAACGATTGGTTTAGTTGCCGGAGA
AACTTCCGGCGATATCTTAG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGE
PTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIH
QFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELA
EQYPVVKAFNDFFARSTRGIIR

Sequences:

>Translated_262_residues
MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGE
PTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIH
QFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELA
EQYPVVKAFNDFFARSTRGIIR
>Mature_262_residues
MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDNQIYQFASIGEANQDLKYAGE
PTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVNTHVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIH
QFCVIGAHVMVGGCSGITQDVPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELA
EQYPVVKAFNDFFARSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=81.6793893129771, Blast_Score=457, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28118; Mature: 28118

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDN
CCCCCEEECCHHHHHCCCEEECCCEECCEEEECCEEEECCCCCCCCEEEEECCEECCCCC
QIYQFASIGEANQDLKYAGEPTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVN
HHHHHHHCCCCCCCCEECCCCCEEEECCCHHHHHEEEEECCCCCCCCEEEECCCCEEEEE
THVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIHQFCVIGAHVMVGGCSGITQD
CCCHHHEEECCEEEEECCCCCCCEEEECCEEEECHHHHHHHHHHHHHHHEEECCCCCCCC
VPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
EQYPVVKAFNDFFARSTRGIIR
HHCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIDKTAFIHPSSIVEEGAIIGAGVYIGPFCIVGSQVEIGAGTELKSHVVVNGITKIGCDN
CCCCCEEECCHHHHHCCCEEECCCEECCEEEECCEEEECCCCCCCCEEEEECCEECCCCC
QIYQFASIGEANQDLKYAGEPTRVEVGDRNRIRESVTIHRGTTQGGGVTKVGCDNLLMVN
HHHHHHHCCCCCCCCEECCCCCEEEECCCHHHHHEEEEECCCCCCCCEEEECCCCEEEEE
THVAHDCVIGNRCILANNAALGGHVEIDDYAIIGGMTAIHQFCVIGAHVMVGGCSGITQD
CCCHHHEEECCEEEEECCCCCCCEEEECCEEEECHHHHHHHHHHHHHHHEEECCCCCCCC
VPPFVIAQGNHATPFGINIEGLKRRGFDKESLHAIRSAYKLLYRSGRTLDEVKPEIAELA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
EQYPVVKAFNDFFARSTRGIIR
HHCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA