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The map label for this gene is lpxD [H]

Identifier: 218928222

GI number: 218928222

Start: 1196418

End: 1197440

Strand: Direct

Name: lpxD [H]

Synonym: YPO1054

Alternate gene names: 218928222

Gene position: 1196418-1197440 (Clockwise)

Preceding gene: 218928221

Following gene: 218928223

Centisome position: 25.71

GC content: 46.24

Gene sequence:

>1023_bases
ATGCCTTCAATTCGACTGGCTGATTTAGCCCAGCAGTTGGATGCACAGGTGCACGGTGATGGCGATCTTGTCATCACCGG
CATCGCTTCTATGCATTCTGCCCAACCTGAGCAAATCACGTTTTTGTCAAACAGCCGCTATCGGGAACAACTTGCATCTT
GCAATGCAGGTGCTGTGGTATTGACTGAGGCTGATTTACCTTTTTGTAAAGTTGCTGCTTTAGTTGTTGAAAATCCTTAT
TTCACCTATGCGCGCATGGCTCAAATAATGGATACCACCCCTCAACCTGCTCAGGATATCGCACCGAGTGCCGTGATTTC
TCCGCAGGCAACGTTGGGCGAGGGGGTTTCTGTTGGTGCGAATGCAGTCATAGAGTCGGGTGTTGTACTCGGCGATAATG
TTGTCATCGGTGCGGGTTGCTTCATTGGTAAGAACACCCATATTGGTGCGGGTAGCCGTTTGTGGGCTAATGTTTCTATC
TATCATGAAGTTGTTATTGGGCAGAATTGCCTGATCCAATCTGGTACTGTCATTGGTGCCGATGGCTTTGGTTATGCAAA
TGATCGTGGTAACTGGGTAAAAATACCGCAGCTTGGTTCTGTACATATTGGCGACCGTGTTGAGATTGGTGCCTGTACAA
CGATTGACCGTGGTGCGCTGGATAACACGATTATTGGTAACGGTGTCATCATTGATAACCAATGTCAGATTGCACATAAC
GTTGTGATTGGCGACAATACGGCAGTTGCCGGTGGTGTTATCATGGCTGGCAGTTTGAAAGTGGGCCGCTATTGTATGAT
TGGCGGTGCCAGTGTGATTAATGGCCATATGGAAATTTGTGACAAAGTAACAATTACCGGGATGGGAATGGTGATGAGAC
CAATCACTGAACCTGGGTTATACTCCTCCGGTATTCCGTTACAACCAAATAAAATGTGGCGCAAAACTGCCGCTCTAGTG
ATGAATATTGATGGTATTAATAAACGCTTAAAAGCTGTTGAGCGTAAAATCGATAAAGAATAA

Upstream 100 bases:

>100_bases
CAAAGGTGGCTATGACGTAGTCATTGATGCGAATGCAGTGGCATACGCTGATTCTTCTAAAGACATTACTGCTGACGTAT
TGAAACAGGTTAAATAAAAC

Downstream 100 bases:

>100_bases
TCACTCTAGCCTGACACTCTGAGTTAATAATCGAACTTACTGGCAGTGATGCCAAAAGTCTACAGAGTTCCTAATTTGCG
GCCTGCCTAATGCCTCCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPSIRLADLAQQLDAQVHGDGDLVITGIASMHSAQPEQITFLSNSRYREQLASCNAGAVVLTEADLPFCKVAALVVENPY
FTYARMAQIMDTTPQPAQDIAPSAVISPQATLGEGVSVGANAVIESGVVLGDNVVIGAGCFIGKNTHIGAGSRLWANVSI
YHEVVIGQNCLIQSGTVIGADGFGYANDRGNWVKIPQLGSVHIGDRVEIGACTTIDRGALDNTIIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKVGRYCMIGGASVINGHMEICDKVTITGMGMVMRPITEPGLYSSGIPLQPNKMWRKTAALV
MNIDGINKRLKAVERKIDKE

Sequences:

>Translated_340_residues
MPSIRLADLAQQLDAQVHGDGDLVITGIASMHSAQPEQITFLSNSRYREQLASCNAGAVVLTEADLPFCKVAALVVENPY
FTYARMAQIMDTTPQPAQDIAPSAVISPQATLGEGVSVGANAVIESGVVLGDNVVIGAGCFIGKNTHIGAGSRLWANVSI
YHEVVIGQNCLIQSGTVIGADGFGYANDRGNWVKIPQLGSVHIGDRVEIGACTTIDRGALDNTIIGNGVIIDNQCQIAHN
VVIGDNTAVAGGVIMAGSLKVGRYCMIGGASVINGHMEICDKVTITGMGMVMRPITEPGLYSSGIPLQPNKMWRKTAALV
MNIDGINKRLKAVERKIDKE
>Mature_339_residues
PSIRLADLAQQLDAQVHGDGDLVITGIASMHSAQPEQITFLSNSRYREQLASCNAGAVVLTEADLPFCKVAALVVENPYF
TYARMAQIMDTTPQPAQDIAPSAVISPQATLGEGVSVGANAVIESGVVLGDNVVIGAGCFIGKNTHIGAGSRLWANVSIY
HEVVIGQNCLIQSGTVIGADGFGYANDRGNWVKIPQLGSVHIGDRVEIGACTTIDRGALDNTIIGNGVIIDNQCQIAHNV
VIGDNTAVAGGVIMAGSLKVGRYCMIGGASVINGHMEICDKVTITGMGMVMRPITEPGLYSSGIPLQPNKMWRKTAALVM
NIDGINKRLKAVERKIDKE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=340, Percent_Identity=82.6470588235294, Blast_Score=589, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35780; Mature: 35648

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIRLADLAQQLDAQVHGDGDLVITGIASMHSAQPEQITFLSNSRYREQLASCNAGAVV
CCCCHHHHHHHHHCCEECCCCCEEEEEEHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEE
LTEADLPFCKVAALVVENPYFTYARMAQIMDTTPQPAQDIAPSAVISPQATLGEGVSVGA
EEECCCCHHHEEEEHHCCCCHHHHHHHHHHCCCCCCHHHCCCCEEECCCHHCCCCCCCCC
NAVIESGVVLGDNVVIGAGCFIGKNTHIGAGSRLWANVSIYHEVVIGQNCLIQSGTVIGA
HHHHHCCEEECCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECCCEEEECCCEEEC
DGFGYANDRGNWVKIPQLGSVHIGDRVEIGACTTIDRGALDNTIIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCCEECCCEEEECEECCCCCCCCCCEEECCCEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKVGRYCMIGGASVINGHMEICDKVTITGMGMVMRPITEPGL
EEECCCCEEECCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEEECCCCCCC
YSSGIPLQPNKMWRKTAALVMNIDGINKRLKAVERKIDKE
CCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PSIRLADLAQQLDAQVHGDGDLVITGIASMHSAQPEQITFLSNSRYREQLASCNAGAVV
CCCHHHHHHHHHCCEECCCCCEEEEEEHHHCCCCCCEEEEECCCHHHHHHHCCCCCEEE
LTEADLPFCKVAALVVENPYFTYARMAQIMDTTPQPAQDIAPSAVISPQATLGEGVSVGA
EEECCCCHHHEEEEHHCCCCHHHHHHHHHHCCCCCCHHHCCCCEEECCCHHCCCCCCCCC
NAVIESGVVLGDNVVIGAGCFIGKNTHIGAGSRLWANVSIYHEVVIGQNCLIQSGTVIGA
HHHHHCCEEECCCEEEECEEEECCCCCCCCCCEEEEEEEEEEEEEECCCEEEECCCEEEC
DGFGYANDRGNWVKIPQLGSVHIGDRVEIGACTTIDRGALDNTIIGNGVIIDNQCQIAHN
CCCCCCCCCCCEEECCCCCCEECCCEEEECEECCCCCCCCCCEEECCCEEECCCCEEEEE
VVIGDNTAVAGGVIMAGSLKVGRYCMIGGASVINGHMEICDKVTITGMGMVMRPITEPGL
EEECCCCEEECCEEEECCCCCCCEEEECCHHHHCCHHHHHCEEEEECCCEEEECCCCCCC
YSSGIPLQPNKMWRKTAALVMNIDGINKRLKAVERKIDKE
CCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8293817 [H]