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The map label for this gene is pepQ [H]

Identifier: 15921672

GI number: 15921672

Start: 1388027

End: 1389106

Strand: Direct

Name: pepQ [H]

Synonym: ST1384

Alternate gene names: 15921672

Gene position: 1388027-1389106 (Clockwise)

Preceding gene: 15921671

Following gene: 15921673

Centisome position: 51.51

GC content: 30.19

Gene sequence:

>1080_bases
ATGCGCCTTCATAAGCTTAAAGAACTATTAGAAGTAAAAGGATTAAAATGTGCAATAATAACCAGTCCAGCTAGTATATT
TTACCTAACTGGATATGATTATATAACGACGGATATAGGTAACTTTGTTGCTTTGGTTTATTGTGATGGTATAGCTACTC
TTATAGTTCCTTTACTAGAATTATATAGGGCACAAGATAAGGTAAAAGAAATAGATTTAGTTGCATATAGTACGACATTA
GAAGGAGAAAAGATTATTAAAGGCTCTTTAAAAGATGCAATTCTTAATTTTATCAAAGAAAATAAAATTGGTTTAGATAT
TCAAAATACTTCTTCAATCTTTTATAATTATTTTAGTAAATTTGAAATAATAGATCTCTCAAAGGATATTTCTATCATGA
GATCAGTAAAAGACCAAGAAGAATTAGAATTAATTAAGAGGGCTGGAGATATAACTACTGCTGCGATGAAAATTGCTCAG
GATAAGTTAACTAACTCAGAAATATCAGAAAAATATCTAGCTGGTATAATAGACATGACTATGAGAACTGAAGGTGCAGA
AGATTACGCGTTTCCTAGTATAGTTGCTTTTGCAGAAAATTCTGCTTTTCCTCATCATATTCCCTCTGATAAAGTAATAA
AAGAAGGACAAAATGCTGTCGTAGATATAGGAGCAAGGTATGAAAAATATTGCTTTGATAGTACTAGAACTTTTTTAAAA
GGAGAAAATACTGAAATAAAGAAAATTTACGAAATAGTTTTACAAGCTCAATTAGAGGCTATTGATAAAGTAAAAGAAGG
CGTAAAGGCTTCAGAAGTTGATTTGGCAGCAAGACGTGTGATTGAAAAAGCTGGTTATGGAAAATATTTTATTCATTCTA
CTGGTCATGGTGTAGGTATTGAAGTTCATGAGTATCCTTCAATTTCACCTAACTCAGATGCTGAACTTAAAGAAAATATG
GTAATAACTATTGAGCCAGGAATATACCTAAAGAATAAATTTGGAATTAGAATAGAAGATACAGTTATTGTAACAAAGAG
AAAACCCATTGTTCTTGAGACTACATTCAAGTATTTATAA

Upstream 100 bases:

>100_bases
GGTGATTTTAGTTTAGAAGAAAAAATTGAATTAATACGTGAAGCCTATGAAATAGCAATAGCTATAAGAGAACCTAATTT
TAAATATAAGGTTGAGAGTT

Downstream 100 bases:

>100_bases
CTTTTTAGTACTCTTTTTAATTTAACTTTATATTTAATGGGGGTCAATAACATTATTGTTATGGAAGAGACATTAAACCA
AGAAAAGATGGTTGAAGAGA

Product: X-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MRLHKLKELLEVKGLKCAIITSPASIFYLTGYDYITTDIGNFVALVYCDGIATLIVPLLELYRAQDKVKEIDLVAYSTTL
EGEKIIKGSLKDAILNFIKENKIGLDIQNTSSIFYNYFSKFEIIDLSKDISIMRSVKDQEELELIKRAGDITTAAMKIAQ
DKLTNSEISEKYLAGIIDMTMRTEGAEDYAFPSIVAFAENSAFPHHIPSDKVIKEGQNAVVDIGARYEKYCFDSTRTFLK
GENTEIKKIYEIVLQAQLEAIDKVKEGVKASEVDLAARRVIEKAGYGKYFIHSTGHGVGIEVHEYPSISPNSDAELKENM
VITIEPGIYLKNKFGIRIEDTVIVTKRKPIVLETTFKYL

Sequences:

>Translated_359_residues
MRLHKLKELLEVKGLKCAIITSPASIFYLTGYDYITTDIGNFVALVYCDGIATLIVPLLELYRAQDKVKEIDLVAYSTTL
EGEKIIKGSLKDAILNFIKENKIGLDIQNTSSIFYNYFSKFEIIDLSKDISIMRSVKDQEELELIKRAGDITTAAMKIAQ
DKLTNSEISEKYLAGIIDMTMRTEGAEDYAFPSIVAFAENSAFPHHIPSDKVIKEGQNAVVDIGARYEKYCFDSTRTFLK
GENTEIKKIYEIVLQAQLEAIDKVKEGVKASEVDLAARRVIEKAGYGKYFIHSTGHGVGIEVHEYPSISPNSDAELKENM
VITIEPGIYLKNKFGIRIEDTVIVTKRKPIVLETTFKYL
>Mature_359_residues
MRLHKLKELLEVKGLKCAIITSPASIFYLTGYDYITTDIGNFVALVYCDGIATLIVPLLELYRAQDKVKEIDLVAYSTTL
EGEKIIKGSLKDAILNFIKENKIGLDIQNTSSIFYNYFSKFEIIDLSKDISIMRSVKDQEELELIKRAGDITTAAMKIAQ
DKLTNSEISEKYLAGIIDMTMRTEGAEDYAFPSIVAFAENSAFPHHIPSDKVIKEGQNAVVDIGARYEKYCFDSTRTFLK
GENTEIKKIYEIVLQAQLEAIDKVKEGVKASEVDLAARRVIEKAGYGKYFIHSTGHGVGIEVHEYPSISPNSDAELKENM
VITIEPGIYLKNKFGIRIEDTVIVTKRKPIVLETTFKYL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=263, Percent_Identity=29.6577946768061, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI264681563, Length=238, Percent_Identity=31.0924369747899, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI93141226, Length=244, Percent_Identity=27.0491803278689, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40385867, Length=242, Percent_Identity=25.2066115702479, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=257, Percent_Identity=40.0778210116732, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1789275, Length=260, Percent_Identity=26.9230769230769, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790282, Length=274, Percent_Identity=24.4525547445255, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17509539, Length=188, Percent_Identity=32.9787234042553, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=284, Percent_Identity=27.8169014084507, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=265, Percent_Identity=28.6792452830189, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321118, Length=275, Percent_Identity=24.7272727272727, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920384, Length=251, Percent_Identity=26.6932270916335, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161078230, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357287, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357079, Length=281, Percent_Identity=24.1992882562278, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17137632, Length=163, Percent_Identity=33.7423312883436, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 40369; Mature: 40369

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLHKLKELLEVKGLKCAIITSPASIFYLTGYDYITTDIGNFVALVYCDGIATLIVPLLE
CCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHEEEEEEECCHHHHHHHHHH
LYRAQDKVKEIDLVAYSTTLEGEKIIKGSLKDAILNFIKENKIGLDIQNTSSIFYNYFSK
HHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCC
FEIIDLSKDISIMRSVKDQEELELIKRAGDITTAAMKIAQDKLTNSEISEKYLAGIIDMT
EEEEECCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MRTEGAEDYAFPSIVAFAENSAFPHHIPSDKVIKEGQNAVVDIGARYEKYCFDSTRTFLK
HCCCCCCCCCCCHHEEEECCCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHHHHC
GENTEIKKIYEIVLQAQLEAIDKVKEGVKASEVDLAARRVIEKAGYGKYFIHSTGHGVGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
EVHEYPSISPNSDAELKENMVITIEPGIYLKNKFGIRIEDTVIVTKRKPIVLETTFKYL
EEECCCCCCCCCCCHHHCCEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCCCC
>Mature Secondary Structure
MRLHKLKELLEVKGLKCAIITSPASIFYLTGYDYITTDIGNFVALVYCDGIATLIVPLLE
CCHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHEEEEEEECCHHHHHHHHHH
LYRAQDKVKEIDLVAYSTTLEGEKIIKGSLKDAILNFIKENKIGLDIQNTSSIFYNYFSK
HHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCC
FEIIDLSKDISIMRSVKDQEELELIKRAGDITTAAMKIAQDKLTNSEISEKYLAGIIDMT
EEEEECCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
MRTEGAEDYAFPSIVAFAENSAFPHHIPSDKVIKEGQNAVVDIGARYEKYCFDSTRTFLK
HCCCCCCCCCCCHHEEEECCCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHHHHC
GENTEIKKIYEIVLQAQLEAIDKVKEGVKASEVDLAARRVIEKAGYGKYFIHSTGHGVGI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCEE
EVHEYPSISPNSDAELKENMVITIEPGIYLKNKFGIRIEDTVIVTKRKPIVLETTFKYL
EEECCCCCCCCCCCHHHCCEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]