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The map label for this gene is moaA

Identifier: 15921671

GI number: 15921671

Start: 1387099

End: 1388040

Strand: Direct

Name: moaA

Synonym: ST1383

Alternate gene names: 15921671

Gene position: 1387099-1388040 (Clockwise)

Preceding gene: 15921670

Following gene: 15921672

Centisome position: 51.47

GC content: 30.04

Gene sequence:

>942_bases
ATGATTGATAGATTTGGAAGGTCGATTGAGGATTTAAGAGTAACTTTAACGCATGTGTGCAATTTTTCTTGTTTTTTCTG
TCATATGGAAGGAGAAGACAATTCTCAGAGTTTGTTGTCTCCAGAAGAAATTTCTTTGGTAGCTAAAGTAGGAATTGAAT
ATGGAATAAGGTCAGTTAAACTTACTGGTGGAGAACCAACTCTAAGAAGGGACTTATTGCAAATTATTAGAGAGTTAAAA
GATGTAGGTATAAAAGAAGTTTCTATGACAACAAACGGTGTTCTTTTATCTACGTTAGCATGGAAACTTAAAGAAGTTGG
ACTAGATAGAGTTAATGTAAGTTTACACTCATTAGATAAACAGCTTTTCAAGGAGATTACTGGAGTTGACGCACTAGATA
AGGTTATTGAAGGAATAAAAGAAGCTATTAAGGCTGGATTAAGACCATTAAAATTAAATTTTGTATTAACTAAGAAAAAT
ATATCGCAATTAGATAATATAATTAATTTTGCTATTGAAACTGGAGTAGATGAACTACATTTAATAGAACTTCATCCGGT
AGGATTAGGTAAAAATACATTTGAATATCATGAAAAATTGGAAAGTATAGAGAAAATATTAAAAGAGAGAGCTGATAAAA
TAGAAATAAGAAGTAAACACTATAGACCAAGATATTATCTCAATAATTTAGTCATTGAGGTTGTGAAACCGTATGCAAAC
CCAATTTTTTGTGCTGGATGTAATAGAATAAGACTAACAGCTGACGGCAAATTAAAGACTTGTTTATATAGACAAGATAA
AGAAATAGATATAATGGATATATTACGTGGTGATTTTAGTTTAGAAGAAAAAATTGAATTAATACGTGAAGCCTATGAAA
TAGCAATAGCTATAAGAGAACCTAATTTTAAATATAAGGTTGAGAGTTATGCGCCTTCATAA

Upstream 100 bases:

>100_bases
CGGCTTCAGCTATAAAATCCATCTTAATGTTACATTTAGGGCATAATAATTCGTTTTTCATATTCAAGATTTAATACTTA
CCAAAACGATAATAAGTGTA

Downstream 100 bases:

>100_bases
GCTTAAAGAACTATTAGAAGTAAAAGGATTAAAATGTGCAATAATAACCAGTCCAGCTAGTATATTTTACCTAACTGGAT
ATGATTATATAACGACGGAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MIDRFGRSIEDLRVTLTHVCNFSCFFCHMEGEDNSQSLLSPEEISLVAKVGIEYGIRSVKLTGGEPTLRRDLLQIIRELK
DVGIKEVSMTTNGVLLSTLAWKLKEVGLDRVNVSLHSLDKQLFKEITGVDALDKVIEGIKEAIKAGLRPLKLNFVLTKKN
ISQLDNIINFAIETGVDELHLIELHPVGLGKNTFEYHEKLESIEKILKERADKIEIRSKHYRPRYYLNNLVIEVVKPYAN
PIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIREPNFKYKVESYAPS

Sequences:

>Translated_313_residues
MIDRFGRSIEDLRVTLTHVCNFSCFFCHMEGEDNSQSLLSPEEISLVAKVGIEYGIRSVKLTGGEPTLRRDLLQIIRELK
DVGIKEVSMTTNGVLLSTLAWKLKEVGLDRVNVSLHSLDKQLFKEITGVDALDKVIEGIKEAIKAGLRPLKLNFVLTKKN
ISQLDNIINFAIETGVDELHLIELHPVGLGKNTFEYHEKLESIEKILKERADKIEIRSKHYRPRYYLNNLVIEVVKPYAN
PIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIREPNFKYKVESYAPS
>Mature_313_residues
MIDRFGRSIEDLRVTLTHVCNFSCFFCHMEGEDNSQSLLSPEEISLVAKVGIEYGIRSVKLTGGEPTLRRDLLQIIRELK
DVGIKEVSMTTNGVLLSTLAWKLKEVGLDRVNVSLHSLDKQLFKEITGVDALDKVIEGIKEAIKAGLRPLKLNFVLTKKN
ISQLDNIINFAIETGVDELHLIELHPVGLGKNTFEYHEKLESIEKILKERADKIEIRSKHYRPRYYLNNLVIEVVKPYAN
PIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIREPNFKYKVESYAPS

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family

Homologues:

Organism=Homo sapiens, GI116734668, Length=305, Percent_Identity=32.4590163934426, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI22027536, Length=305, Percent_Identity=32.4590163934426, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786999, Length=311, Percent_Identity=32.7974276527331, Blast_Score=146, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17561210, Length=316, Percent_Identity=32.9113924050633, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32566331, Length=308, Percent_Identity=32.7922077922078, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32566329, Length=303, Percent_Identity=32.3432343234323, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=33.4394904458599, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=33.968253968254, Blast_Score=145, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAA_SULTO (Q971H1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377340.1
- ProteinModelPortal:   Q971H1
- SMR:   Q971H1
- GeneID:   1459411
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1383
- NMPDR:   fig|273063.1.peg.1508
- HOGENOM:   HBG529885
- OMA:   EMENSQF
- ProtClustDB:   CLSK802683
- BioCyc:   STOK273063:ST1383-MONOMER
- HAMAP:   MF_01225_A
- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013485
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00729
- TIGRFAMs:   TIGR02668

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM

EC number: NA

Molecular weight: Translated: 35779; Mature: 35779

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: BINDING 13-13 BINDING 60-60 BINDING 64-64 BINDING 90-90 BINDING 114-114 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRFGRSIEDLRVTLTHVCNFSCFFCHMEGEDNSQSLLSPEEISLVAKVGIEYGIRSVK
CCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
LTGGEPTLRRDLLQIIRELKDVGIKEVSMTTNGVLLSTLAWKLKEVGLDRVNVSLHSLDK
EECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHH
QLFKEITGVDALDKVIEGIKEAIKAGLRPLKLNFVLTKKNISQLDNIINFAIETGVDELH
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEE
LIELHPVGLGKNTFEYHEKLESIEKILKERADKIEIRSKHYRPRYYLNNLVIEVVKPYAN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHCCC
PIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIRE
EEEEECCCEEEEEECCCCHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHEEEEEEC
PNFKYKVESYAPS
CCCEEEECCCCCC
>Mature Secondary Structure
MIDRFGRSIEDLRVTLTHVCNFSCFFCHMEGEDNSQSLLSPEEISLVAKVGIEYGIRSVK
CCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEE
LTGGEPTLRRDLLQIIRELKDVGIKEVSMTTNGVLLSTLAWKLKEVGLDRVNVSLHSLDK
EECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEHHHHHHHH
QLFKEITGVDALDKVIEGIKEAIKAGLRPLKLNFVLTKKNISQLDNIINFAIETGVDELH
HHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHCCCCCEE
LIELHPVGLGKNTFEYHEKLESIEKILKERADKIEIRSKHYRPRYYLNNLVIEVVKPYAN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHHHHHHHHHHHHHCCC
PIFCAGCNRIRLTADGKLKTCLYRQDKEIDIMDILRGDFSLEEKIELIREAYEIAIAIRE
EEEEECCCEEEEEECCCCHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHEEEEEEC
PNFKYKVESYAPS
CCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479