Click here to switch to the map view.

The map label for this gene is hmgA [H]

Identifier: 15921637

GI number: 15921637

Start: 1359859

End: 1361094

Strand: Direct

Name: hmgA [H]

Synonym: ST1352

Alternate gene names: 15921637

Gene position: 1359859-1361094 (Clockwise)

Preceding gene: 15921636

Following gene: 15921638

Centisome position: 50.46

GC content: 36.49

Gene sequence:

>1236_bases
ATGCAAGAGATAATTGATGAGGTAGTTAATAAGGCTCTTAAAGGTGAGATCGAGCTTCATGAGATAGATAATTTTTTAGA
AGCAAATGCTGCAATGGTAGCTAGAAGATTAGTTATAGAAAAACTAACAAATACTAAACTTCCTTCTATTGGATCAACAA
TTCTTGATTATGCTGAGATAAAAAATAGAAACGCAGAAAACGTTATAGGTGGAATTCAGATACCAGTAGGCGTTATAGGC
CCTTTAAGAGTAAACGGTGATTATGCTAAAGGAGATTTTTATGTTCCCCTAGCAACTACTGAAGGTGCGTTAATAGCCAG
TGTAAATAGGGGTGCAAAAGCTATAACTAAAAGTGGTGGTGCAAGAGTAAAGATAATTTTTGATGGAATGACTAGAGCAC
CAGTTTTTAAACTTAATAGCATAGAAGATGTTGCTGATTTTCTAAAATGGATAAAGGATAATTTTTCAAAGATAAAAGAG
ATTGCAGAGAGCACTACTTCACATGGTAAGCTAATGAACATAGAACCATACGTTTTAGGTAATAATGTATGGCTTAGATT
TGTTTTTGAAACGGGTGATGCAATGGGTATGAACATGGTTACTGTAGCTACTGAGAAAGCATGTGAGTTTATTGAGAGAG
AATTTGGAAGGGCTGTATGTTTGGCGGTAAGTGGTAATATGTGTAGTGATAAGAAACAATCTCAAGTAAATTCTCTGCAT
GGTAGAGGTAAGACTGTAGTCGCAGAGGCATTAATTCCAAATGATGTGATTAAGACTGTGTTAAAATCTGATTCAGTATT
AATTCATGAAGTTAATTTAAGGAAAAATTGGTTAGGCGGAGCTAGGGCAGGTACAATGTTTCAGTTTAACGCTCATTTTG
CTAATATTGTTACAGCTATTTTTATAGCCACTGGACAAGATGTAGCTCAAGTCGTTGAAAGCAGTTCCGGGTACACATGG
ACTGAAATACGAGATAATGGATTATACATTTCTGTGACTTTAACGTCGTTAGAAGTTGGTACTATTGGTGGGGGTACTAG
ATTACCAACTCAAAGGGAAGCTTTGTCAATTATGAGAGTAGATGGGCCAGGTAATCCTCCTGGAAGTAATGCAAGAAAAT
TTGCAGAAATTGTAGCATCTACTGTTCTTGCGGGAGAACTGAATTTACTTGCAGCATTGGCGAATAAGGAATTAGGTAAA
GCCCATTTAAGGTTAGGCAGAGGGGCCAAAGTTTAA

Upstream 100 bases:

>100_bases
ATTAAAGAAGGTGCTGAGGTTGAAGCTGTTCTAAGGAGAATTACTGCTGATTCCAATAATGGTTTAATACAGTACGGTAT
TAAATTTAGAGTGATAGATA

Downstream 100 bases:

>100_bases
AAGTTATGAAAAATTAACTTAACCATATGAGTCAAATTCCTAAAGAGCTTGAAAAAGTAATTGAGCTAACAAGAGAACAA
AATAGATGGAGAAGAACAGA

Product: 3-hydroxy-3-methylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MQEIIDEVVNKALKGEIELHEIDNFLEANAAMVARRLVIEKLTNTKLPSIGSTILDYAEIKNRNAENVIGGIQIPVGVIG
PLRVNGDYAKGDFYVPLATTEGALIASVNRGAKAITKSGGARVKIIFDGMTRAPVFKLNSIEDVADFLKWIKDNFSKIKE
IAESTTSHGKLMNIEPYVLGNNVWLRFVFETGDAMGMNMVTVATEKACEFIEREFGRAVCLAVSGNMCSDKKQSQVNSLH
GRGKTVVAEALIPNDVIKTVLKSDSVLIHEVNLRKNWLGGARAGTMFQFNAHFANIVTAIFIATGQDVAQVVESSSGYTW
TEIRDNGLYISVTLTSLEVGTIGGGTRLPTQREALSIMRVDGPGNPPGSNARKFAEIVASTVLAGELNLLAALANKELGK
AHLRLGRGAKV

Sequences:

>Translated_411_residues
MQEIIDEVVNKALKGEIELHEIDNFLEANAAMVARRLVIEKLTNTKLPSIGSTILDYAEIKNRNAENVIGGIQIPVGVIG
PLRVNGDYAKGDFYVPLATTEGALIASVNRGAKAITKSGGARVKIIFDGMTRAPVFKLNSIEDVADFLKWIKDNFSKIKE
IAESTTSHGKLMNIEPYVLGNNVWLRFVFETGDAMGMNMVTVATEKACEFIEREFGRAVCLAVSGNMCSDKKQSQVNSLH
GRGKTVVAEALIPNDVIKTVLKSDSVLIHEVNLRKNWLGGARAGTMFQFNAHFANIVTAIFIATGQDVAQVVESSSGYTW
TEIRDNGLYISVTLTSLEVGTIGGGTRLPTQREALSIMRVDGPGNPPGSNARKFAEIVASTVLAGELNLLAALANKELGK
AHLRLGRGAKV
>Mature_411_residues
MQEIIDEVVNKALKGEIELHEIDNFLEANAAMVARRLVIEKLTNTKLPSIGSTILDYAEIKNRNAENVIGGIQIPVGVIG
PLRVNGDYAKGDFYVPLATTEGALIASVNRGAKAITKSGGARVKIIFDGMTRAPVFKLNSIEDVADFLKWIKDNFSKIKE
IAESTTSHGKLMNIEPYVLGNNVWLRFVFETGDAMGMNMVTVATEKACEFIEREFGRAVCLAVSGNMCSDKKQSQVNSLH
GRGKTVVAEALIPNDVIKTVLKSDSVLIHEVNLRKNWLGGARAGTMFQFNAHFANIVTAIFIATGQDVAQVVESSSGYTW
TEIRDNGLYISVTLTSLEVGTIGGGTRLPTQREALSIMRVDGPGNPPGSNARKFAEIVASTVLAGELNLLAALANKELGK
AHLRLGRGAKV

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=406, Percent_Identity=42.6108374384236, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI196049380, Length=291, Percent_Identity=46.0481099656357, Blast_Score=246, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI25144592, Length=409, Percent_Identity=42.7872860635697, Blast_Score=301, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323483, Length=413, Percent_Identity=42.6150121065375, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6323565, Length=412, Percent_Identity=42.2330097087379, Blast_Score=289, Evalue=7e-79,
Organism=Drosophila melanogaster, GI281362379, Length=402, Percent_Identity=42.2885572139304, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI45553469, Length=402, Percent_Identity=42.2885572139304, Blast_Score=268, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24649399, Length=402, Percent_Identity=42.2885572139304, Blast_Score=268, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44370; Mature: 44370

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIIDEVVNKALKGEIELHEIDNFLEANAAMVARRLVIEKLTNTKLPSIGSTILDYAEI
CHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KNRNAENVIGGIQIPVGVIGPLRVNGDYAKGDFYVPLATTEGALIASVNRGAKAITKSGG
CCCCHHHCCCCEEECCEEECEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHCCCC
ARVKIIFDGMTRAPVFKLNSIEDVADFLKWIKDNFSKIKEIAESTTSHGKLMNIEPYVLG
CEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEC
NNVWLRFVFETGDAMGMNMVTVATEKACEFIEREFGRAVCLAVSGNMCSDKKQSQVNSLH
CCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHC
GRGKTVVAEALIPNDVIKTVLKSDSVLIHEVNLRKNWLGGARAGTMFQFNAHFANIVTAI
CCCCEEEEHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHH
FIATGQDVAQVVESSSGYTWTEIRDNGLYISVTLTSLEVGTIGGGTRLPTQREALSIMRV
HHCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEEEEEECCCCCCCCCHHHEEEEEEE
DGPGNPPGSNARKFAEIVASTVLAGELNLLAALANKELGKAHLRLGRGAKV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHHCCCCCCC
>Mature Secondary Structure
MQEIIDEVVNKALKGEIELHEIDNFLEANAAMVARRLVIEKLTNTKLPSIGSTILDYAEI
CHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KNRNAENVIGGIQIPVGVIGPLRVNGDYAKGDFYVPLATTEGALIASVNRGAKAITKSGG
CCCCHHHCCCCEEECCEEECEEEECCCCCCCCEEEEEECCCCCEEEECCCCHHHHHCCCC
ARVKIIFDGMTRAPVFKLNSIEDVADFLKWIKDNFSKIKEIAESTTSHGKLMNIEPYVLG
CEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEC
NNVWLRFVFETGDAMGMNMVTVATEKACEFIEREFGRAVCLAVSGNMCSDKKQSQVNSLH
CCEEEEEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHC
GRGKTVVAEALIPNDVIKTVLKSDSVLIHEVNLRKNWLGGARAGTMFQFNAHFANIVTAI
CCCCEEEEHHHCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHHHH
FIATGQDVAQVVESSSGYTWTEIRDNGLYISVTLTSLEVGTIGGGTRLPTQREALSIMRV
HHCCCHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEEEEEECCCCCCCCCHHHEEEEEEE
DGPGNPPGSNARKFAEIVASTVLAGELNLLAALANKELGKAHLRLGRGAKV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171410; 10701121; 11427726 [H]