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The map label for this gene is trpC

Identifier: 159184873

GI number: 159184873

Start: 1672673

End: 1673488

Strand: Direct

Name: trpC

Synonym: Atu1688

Alternate gene names: 159184873

Gene position: 1672673-1673488 (Clockwise)

Preceding gene: 15888992

Following gene: 15888994

Centisome position: 58.86

GC content: 62.38

Gene sequence:

>816_bases
ATGAGCGACATTCTCAAAAAGATCGAGACCTACAAGCTGGAGGAAATCGCCGCCGCCAAGGCCAAGGTTTCGCTGGCCGA
TCTGAAGGCCATGGCCGCAGACCAGAGCGCACCGCGCGGTTTCTATAAGGCGCTGCGCGCAAAGCAGGCCGCAGGCAAGT
TCGGCCTCATCGCCGAAATCAAGAAGGCCAGCCCCTCCAAGGGCCTCATCCGCCCGGATTTCGACCCGCCGGCGCTGGCC
GCTGCCTATGAGGCGGGTGGTGCCGCCTGCCTCTCGGTCCTGACGGATACGCCGAGCTTTCAGGGCGCGCCGGAATTTCT
GACCGCCGCCCGTAATGCCTGCGCTCTGCCGGCACTGCGCAAGGATTTCATGTTCGATACCTATCAGGTGCATGAGGCCC
GCGCCTGGGGTGCGGATTGCATCCTGCTGATCATGGCATCGCTTTCCGACGACGAGGCGAAGCGGCTCGAGGACGAGGCT
TTTGCGCTTGGCATGGACGTGCTGATCGAAGTTCATGATGCGGAGGAAACCGAACGGGCGCTGAAACTCACTTCCCCGCT
TCTCGGTATCAACAACCGCAATCTGCGCACCTTCGAAGTCGGCCTCGAAACCAGCGAGAAGCTCGCAGGCCTCGTGCCGG
CCGACAAGCTGCTGGTCGGCGAAAGCGGCATCTTCACCTTCGAGGATTGCCAGCGCCTGGAAAAGAGCGGCATCAGCACA
TTCCTCGTCGGCGAAAGCCTGATGCGCAAGGACGATGTGACGGCGGCGACCAAGGCCCTGCTGACCGGCCACTCCGGCAT
TCTGGCCGCGGAATAA

Upstream 100 bases:

>100_bases
GCCAGCGATGCGCTCGACAGCGGCAAGGCCGCCGCGGCGCTCGACCGTCTGGTCGCCGTATCCAACGAAGCCAATTCAGG
GCAGGAATGAGAGCGAGACC

Downstream 100 bases:

>100_bases
TACGCCGATGAGCGATGGCCAGAAGCTCACCCATATCGATGCGAGCGGCGAGGCGCATATGGTCGATGTCGGCGACAAGG
CCGAGACCGTCCGTGTCGCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSDILKKIETYKLEEIAAAKAKVSLADLKAMAADQSAPRGFYKALRAKQAAGKFGLIAEIKKASPSKGLIRPDFDPPALA
AAYEAGGAACLSVLTDTPSFQGAPEFLTAARNACALPALRKDFMFDTYQVHEARAWGADCILLIMASLSDDEAKRLEDEA
FALGMDVLIEVHDAEETERALKLTSPLLGINNRNLRTFEVGLETSEKLAGLVPADKLLVGESGIFTFEDCQRLEKSGIST
FLVGESLMRKDDVTAATKALLTGHSGILAAE

Sequences:

>Translated_271_residues
MSDILKKIETYKLEEIAAAKAKVSLADLKAMAADQSAPRGFYKALRAKQAAGKFGLIAEIKKASPSKGLIRPDFDPPALA
AAYEAGGAACLSVLTDTPSFQGAPEFLTAARNACALPALRKDFMFDTYQVHEARAWGADCILLIMASLSDDEAKRLEDEA
FALGMDVLIEVHDAEETERALKLTSPLLGINNRNLRTFEVGLETSEKLAGLVPADKLLVGESGIFTFEDCQRLEKSGIST
FLVGESLMRKDDVTAATKALLTGHSGILAAE
>Mature_270_residues
SDILKKIETYKLEEIAAAKAKVSLADLKAMAADQSAPRGFYKALRAKQAAGKFGLIAEIKKASPSKGLIRPDFDPPALAA
AYEAGGAACLSVLTDTPSFQGAPEFLTAARNACALPALRKDFMFDTYQVHEARAWGADCILLIMASLSDDEAKRLEDEAF
ALGMDVLIEVHDAEETERALKLTSPLLGINNRNLRTFEVGLETSEKLAGLVPADKLLVGESGIFTFEDCQRLEKSGISTF
LVGESLMRKDDVTAATKALLTGHSGILAAE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=267, Percent_Identity=38.9513108614232, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=221, Percent_Identity=38.9140271493213, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_AGRT5 (Q7CYR2)

Other databases:

- EMBL:   AE007869
- RefSeq:   NP_354674.2
- HSSP:   P00909
- ProteinModelPortal:   Q7CYR2
- SMR:   Q7CYR2
- STRING:   Q7CYR2
- GeneID:   1133726
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1688
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29039; Mature: 28907

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILKKIETYKLEEIAAAKAKVSLADLKAMAADQSAPRGFYKALRAKQAAGKFGLIAEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHH
KKASPSKGLIRPDFDPPALAAAYEAGGAACLSVLTDTPSFQGAPEFLTAARNACALPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
KDFMFDTYQVHEARAWGADCILLIMASLSDDEAKRLEDEAFALGMDVLIEVHDAEETERA
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCCHHHHHH
LKLTSPLLGINNRNLRTFEVGLETSEKLAGLVPADKLLVGESGIFTFEDCQRLEKSGIST
HHHHCCHHCCCCCCEEEEEECCCCHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHCCCEE
FLVGESLMRKDDVTAATKALLTGHSGILAAE
EEHHHHHHHHCCHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
SDILKKIETYKLEEIAAAKAKVSLADLKAMAADQSAPRGFYKALRAKQAAGKFGLIAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHH
KKASPSKGLIRPDFDPPALAAAYEAGGAACLSVLTDTPSFQGAPEFLTAARNACALPALR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHH
KDFMFDTYQVHEARAWGADCILLIMASLSDDEAKRLEDEAFALGMDVLIEVHDAEETERA
HHHHCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHEEEECCCHHHHHH
LKLTSPLLGINNRNLRTFEVGLETSEKLAGLVPADKLLVGESGIFTFEDCQRLEKSGIST
HHHHCCHHCCCCCCEEEEEECCCCHHHHHCCCCCCCEEECCCCCEEHHHHHHHHHCCCEE
FLVGESLMRKDDVTAATKALLTGHSGILAAE
EEHHHHHHHHCCHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194