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The map label for this gene is pdxA

Identifier: 159184615

GI number: 159184615

Start: 1092629

End: 1093651

Strand: Reverse

Name: pdxA

Synonym: Atu1104

Alternate gene names: 159184615

Gene position: 1093651-1092629 (Counterclockwise)

Preceding gene: 15888445

Following gene: 15888443

Centisome position: 38.49

GC content: 62.37

Gene sequence:

>1023_bases
GTGACACATGCATCCCTGCCGCTTGCCCTGACCCAGGGAGATCCAGCCGGTATCGGCCCCGATATCGCCATCAACGCCTG
GGCAAAGCGCAGGGAGAACGGCGTGCCGCCATTTATCTTCATCGGCGATCCCGATGTGGTGGCGAGCCGTGCGGCGCTGA
TCGGCGTGCCGGTCAATATCGAGACCTGCGATCCGGAAAGCGCCGTTAGCCTGTTCGAGCGCGCTTTCCCCATCCTTCCT
CTTCCTGTCGGGTTTGACGTGCAGGCGGGTCAGCCGCATGTCGGCGCTGCCCACGCGACGATCAAGGCCATCGAGATGGC
CGTTTCCCTGACGGTTGAAGGCAGGGCTGCGGCTGTCGTCACCAATCCGATTGCGAAATCCGTGCTTTACGAAGCCGGAT
TCGGTTTTCCCGGCCATACGGAATTCCTGGCCGATCTCGCGCTGCGTCAGACGGGCAAGCCGGTAACACCGGTGATGATG
ATCGCCGGCCCCAAGGTTCGGGTCGTGCCTGTCACTATCCATATCCCTATCAAGGATGTGCCAACCGCGCTGACTGAAGA
GCTGATTGTAACAACCTGCCGCATTATCGATACGGACCTTCGGGAAAAATTCGGGATCGCGGCGCCACGCCTCGCCGTCG
CCGGTCTCAACCCGCATGCGGGTGAAGATGGCGCGCTCGGCACCGAGGATCGTGATGTGGTTCATCCCGCGACCATACGG
TTGCGGAAGGACGGCATCGACGCCTTCGGCCCCCTGCCCGCCGACACCATGTTCCACGATGCCGCCCGCAAGCGTTATGA
CGTGGCGGTGTGCATGTATCACGATCAGGCACTCATTCCGGCCAAGGCGCTCGGCTTTGACGATTCGGTCAATGTCACGC
TCGGCCTGCCCTTCATCCGCACGTCACCCGACCATGGCACTGCCTTCGGCATTGCCGGCCAGGGCATTGCCAGTGAGACG
AGCCTTGTCGCGGCGCTGAAGATGGCAGCGGAGATTTATGCCCGCAGCCGGGTTGGCGCGTAA

Upstream 100 bases:

>100_bases
AGGACGGCGAAAACCCGAACGAGAAGAAATATATCGAGGAACTGCGCAAGAAGGCGCAGATCGTCAACACCTGATATTGA
TACGAGAGCCGGGTCTTTCC

Downstream 100 bases:

>100_bases
TGGCCGCCATCGATGGACTGCCGCCGCTGCGCGATGTCATCCAGCGCCACGGGCTCGATGCGAAGAAATCGCTTGGTCAG
AATTTCCTGTTCGACCTCAA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MTHASLPLALTQGDPAGIGPDIAINAWAKRRENGVPPFIFIGDPDVVASRAALIGVPVNIETCDPESAVSLFERAFPILP
LPVGFDVQAGQPHVGAAHATIKAIEMAVSLTVEGRAAAVVTNPIAKSVLYEAGFGFPGHTEFLADLALRQTGKPVTPVMM
IAGPKVRVVPVTIHIPIKDVPTALTEELIVTTCRIIDTDLREKFGIAAPRLAVAGLNPHAGEDGALGTEDRDVVHPATIR
LRKDGIDAFGPLPADTMFHDAARKRYDVAVCMYHDQALIPAKALGFDDSVNVTLGLPFIRTSPDHGTAFGIAGQGIASET
SLVAALKMAAEIYARSRVGA

Sequences:

>Translated_340_residues
MTHASLPLALTQGDPAGIGPDIAINAWAKRRENGVPPFIFIGDPDVVASRAALIGVPVNIETCDPESAVSLFERAFPILP
LPVGFDVQAGQPHVGAAHATIKAIEMAVSLTVEGRAAAVVTNPIAKSVLYEAGFGFPGHTEFLADLALRQTGKPVTPVMM
IAGPKVRVVPVTIHIPIKDVPTALTEELIVTTCRIIDTDLREKFGIAAPRLAVAGLNPHAGEDGALGTEDRDVVHPATIR
LRKDGIDAFGPLPADTMFHDAARKRYDVAVCMYHDQALIPAKALGFDDSVNVTLGLPFIRTSPDHGTAFGIAGQGIASET
SLVAALKMAAEIYARSRVGA
>Mature_339_residues
THASLPLALTQGDPAGIGPDIAINAWAKRRENGVPPFIFIGDPDVVASRAALIGVPVNIETCDPESAVSLFERAFPILPL
PVGFDVQAGQPHVGAAHATIKAIEMAVSLTVEGRAAAVVTNPIAKSVLYEAGFGFPGHTEFLADLALRQTGKPVTPVMMI
AGPKVRVVPVTIHIPIKDVPTALTEELIVTTCRIIDTDLREKFGIAAPRLAVAGLNPHAGEDGALGTEDRDVVHPATIRL
RKDGIDAFGPLPADTMFHDAARKRYDVAVCMYHDQALIPAKALGFDDSVNVTLGLPFIRTSPDHGTAFGIAGQGIASETS
LVAALKMAAEIYARSRVGA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=40.4255319148936, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_AGRT5 (Q8UGD4)

Other databases:

- EMBL:   AE007869
- PIR:   AG2712
- PIR:   E97494
- RefSeq:   NP_354125.2
- ProteinModelPortal:   Q8UGD4
- SMR:   Q8UGD4
- STRING:   Q8UGD4
- GeneID:   1133142
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1104
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   LETAYQM
- PhylomeDB:   Q8UGD4
- ProtClustDB:   PRK05312
- BioCyc:   ATUM176299-1:ATU1104-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35728; Mature: 35596

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: BINDING 139-139 BINDING 140-140 BINDING 282-282 BINDING 291-291 BINDING 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHASLPLALTQGDPAGIGPDIAINAWAKRRENGVPPFIFIGDPDVVASRAALIGVPVNI
CCCCCCCEEEECCCCCCCCCCEEEEHHHHHHCCCCCCEEEECCCHHHHCCEEEEEECEEE
ETCDPESAVSLFERAFPILPLPVGFDVQAGQPHVGAAHATIKAIEMAVSLTVEGRAAAVV
ECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHEEEEEEEEEEECCCEEEEE
TNPIAKSVLYEAGFGFPGHTEFLADLALRQTGKPVTPVMMIAGPKVRVVPVTIHIPIKDV
ECHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEEEEEECCCC
PTALTEELIVTTCRIIDTDLREKFGIAAPRLAVAGLNPHAGEDGALGTEDRDVVHPATIR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCEEEE
LRKDGIDAFGPLPADTMFHDAARKRYDVAVCMYHDQALIPAKALGFDDSVNVTLGLPFIR
EEECCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCHHHCCCCCCCEEEEECCEEE
TSPDHGTAFGIAGQGIASETSLVAALKMAAEIYARSRVGA
ECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THASLPLALTQGDPAGIGPDIAINAWAKRRENGVPPFIFIGDPDVVASRAALIGVPVNI
CCCCCCEEEECCCCCCCCCCEEEEHHHHHHCCCCCCEEEECCCHHHHCCEEEEEECEEE
ETCDPESAVSLFERAFPILPLPVGFDVQAGQPHVGAAHATIKAIEMAVSLTVEGRAAAVV
ECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHEEEEEEEEEEECCCEEEEE
TNPIAKSVLYEAGFGFPGHTEFLADLALRQTGKPVTPVMMIAGPKVRVVPVTIHIPIKDV
ECHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEEEEEECCCC
PTALTEELIVTTCRIIDTDLREKFGIAAPRLAVAGLNPHAGEDGALGTEDRDVVHPATIR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEECCEEEE
LRKDGIDAFGPLPADTMFHDAARKRYDVAVCMYHDQALIPAKALGFDDSVNVTLGLPFIR
EEECCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCCCCHHHCCCCCCCEEEEECCEEE
TSPDHGTAFGIAGQGIASETSLVAALKMAAEIYARSRVGA
ECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194