Click here to switch to the map view.

The map label for this gene is emrB [C]

Identifier: 159184607

GI number: 159184607

Start: 1077064

End: 1078686

Strand: Direct

Name: emrB [C]

Synonym: Atu1086

Alternate gene names: 159184607

Gene position: 1077064-1078686 (Clockwise)

Preceding gene: 159184606

Following gene: 159184608

Centisome position: 37.9

GC content: 58.35

Gene sequence:

>1623_bases
ATGGTGGAAGCCGCCATTCCCGCCGCGCCACAGCCGGTGGAGCGGCCGTTATGGCTCCGGCTCTGTTTCATCTTTGCCGG
CCTGTCGTTTTTCATCACGCAAGGTCTGGGCATGAACCTCGTCATGGCCAATATCTACCAGTTGCAGGGTGAGTTCTCCG
CGACGGTGGCCGAGGTCGCCTGGCTTTCCGCCGCCTACATGGCGCCTTATGCCACCTTTTCCATCGCGCTTTTTAAGGTA
CGGGCACAATATGGCCTGCGGCCCTTTGCTGAACTCTCGATCATCGCTTTCGTCGTTGCCTCCTGCCTCAATCTTTTCGT
GACGGACCTGCATTCGGCGATCGTCATCCGCTTCGTCAGCGGCATGGCGGCGGCGCCGATCTCCTCGCTCGGCTTTCTCT
ATATTCTCGAGGCCTTTCCGCCGGCGCGGAAATTCTCGCTCGGCTTCAGCATCGCGCTGACAGGCACCTTGCTGTCGGCG
CCACTCGCCCGCATCGTGTCACCCTCCCTGCTGGAAATCGACGGCTGGAACGCGCTGTATTCCATGGAAGTGGGTTTTGC
GTTGATCTCGCTCGCCGTGATCTATGTTCTGAAAGTCACGCCGCCGCCGCGCGCGAAAGTCATCGAGCGCATGGATATCT
TGAGCTACGTGCTGTTTGCGGGTGGTCTCGGTTGCCTCGCGGTCATGCTCACGCTCGGCAGGTTTTACTGGTGGTTTGAA
ACGTGGTGGCTTGGGGCGCTGCTGGCGACATCCATTGCGCTTCTGACACTGATGGCCTTCATCGAACTGCCGCGCAAGAA
CCCGCTGCTTGACCTGCGCTGGATTTTTTCCAAAACCAACCTGCATGTGATGGCTGTGTTGCTTATCTACCGCGCGGTTT
CTTCCGAGCAGTCCTCAACCGCTGTCAGCTTTTATCAGCAACTCGGCCTCTTGAACGACCAGACGACAACGCTCTACGCC
CTTGTGCTGCTGGCGACCGTACTGGGCGGCGCGGCCTGCGCCTGGCTGATGTTGAGCAAATATGTCGATACGGCCCATGT
CATTGCACTCACGCTGATCGCTGCCGGTTCATTTTTGGACAGCCAGTCCACCAACATGACTCGGCCGGAACAGATGTATT
TCAGCCAGATGATGATCGCTTTCGGGGCAGCCATGTTCCTGCCGCCGGTCATGGCCAAGGGCTTTGCGGCGGCTCTTGGT
CGGGGAGCGCCCTATCTGGTGAATTTCATCGCCATCTTTCTGTTCACCCAGATCACCGGCTCGATGCTGATGACTGGTCT
GCTCGGCAGCTTTGTGACCCTGCGTGAAAAGTTTCACTCCAATATTCTGGTGGAGAATATTCTCCTTACCAATCCGCTGG
TTGCCCAGCGCGTGTCCCAGCTTTCCGGGGCTTACAGCCACGTCATTACCGATCCGGCGCTGCTGAAGGCCGAGGGCCTG
ACATTGCTTGCCCAGCAGGTCAGCCGGGAAGCCTATGTGCTGGCCTATAACGATACGTTTCTGCTCATCTCCGTCGTTTC
CGCGCTGGCGCTGGCAGTGCTTTTAATCCACCTTGTCTGGATGCGTGTCCGACCTTTCCTGTCGCGGGAAAAGACCGATA
CTGCGCCGGCGCTACAGTCATGA

Upstream 100 bases:

>100_bases
CGATGCCACTTCCCAAAATACCGAGGTGACCGCCAAATCCTCCGAGCTTCCGGAAAAGGACGCGACTGTACCGCCAGATA
CTGCCAGCACGGCCGAGACG

Downstream 100 bases:

>100_bases
AAATTCCAAGAGTGACAAAATGCTGAAGAAGTTTTTTACCCCCGTTTCCATCCTCGTGCTGCTCGGCGGCATCGCCGGCG
TTGCGCTGGTGCTTTACGCC

Product: MFS permease

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Facilitator Superfamily Protein; Transport Protein Transmembrane; EmrB/QacA Family Drug Resistance Transporter; Facilitator Superfamily Transporter; Multidrug Resistance Protein B; Drug Resistance Transporter EmrB/QacA Subfamily; MFS Drug Efflux Transporter RmrB; Transporter Facilitator Family; Multidrug Efflux Transporter Protein; Transmembrane Efflux Pump Protein; Tat Pathway Signal Sequence Domain Protein; Multidrug Resistance Efflux System Protein; MFS Drug Efflux Transporter; MFS Permease; LOW QUALITY PROTEIN MFS Drug Efflux Transporter; Efflux Protein; Facilitator Superfamily Transporter Protein; Drug Resistance Transporter EmrB/QacA Family Protein; MFS Family Transporter; HlyD Family Protein; Facilitator Family Transporter; Facilitator Superfamily Permease

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MVEAAIPAAPQPVERPLWLRLCFIFAGLSFFITQGLGMNLVMANIYQLQGEFSATVAEVAWLSAAYMAPYATFSIALFKV
RAQYGLRPFAELSIIAFVVASCLNLFVTDLHSAIVIRFVSGMAAAPISSLGFLYILEAFPPARKFSLGFSIALTGTLLSA
PLARIVSPSLLEIDGWNALYSMEVGFALISLAVIYVLKVTPPPRAKVIERMDILSYVLFAGGLGCLAVMLTLGRFYWWFE
TWWLGALLATSIALLTLMAFIELPRKNPLLDLRWIFSKTNLHVMAVLLIYRAVSSEQSSTAVSFYQQLGLLNDQTTTLYA
LVLLATVLGGAACAWLMLSKYVDTAHVIALTLIAAGSFLDSQSTNMTRPEQMYFSQMMIAFGAAMFLPPVMAKGFAAALG
RGAPYLVNFIAIFLFTQITGSMLMTGLLGSFVTLREKFHSNILVENILLTNPLVAQRVSQLSGAYSHVITDPALLKAEGL
TLLAQQVSREAYVLAYNDTFLLISVVSALALAVLLIHLVWMRVRPFLSREKTDTAPALQS

Sequences:

>Translated_540_residues
MVEAAIPAAPQPVERPLWLRLCFIFAGLSFFITQGLGMNLVMANIYQLQGEFSATVAEVAWLSAAYMAPYATFSIALFKV
RAQYGLRPFAELSIIAFVVASCLNLFVTDLHSAIVIRFVSGMAAAPISSLGFLYILEAFPPARKFSLGFSIALTGTLLSA
PLARIVSPSLLEIDGWNALYSMEVGFALISLAVIYVLKVTPPPRAKVIERMDILSYVLFAGGLGCLAVMLTLGRFYWWFE
TWWLGALLATSIALLTLMAFIELPRKNPLLDLRWIFSKTNLHVMAVLLIYRAVSSEQSSTAVSFYQQLGLLNDQTTTLYA
LVLLATVLGGAACAWLMLSKYVDTAHVIALTLIAAGSFLDSQSTNMTRPEQMYFSQMMIAFGAAMFLPPVMAKGFAAALG
RGAPYLVNFIAIFLFTQITGSMLMTGLLGSFVTLREKFHSNILVENILLTNPLVAQRVSQLSGAYSHVITDPALLKAEGL
TLLAQQVSREAYVLAYNDTFLLISVVSALALAVLLIHLVWMRVRPFLSREKTDTAPALQS
>Mature_540_residues
MVEAAIPAAPQPVERPLWLRLCFIFAGLSFFITQGLGMNLVMANIYQLQGEFSATVAEVAWLSAAYMAPYATFSIALFKV
RAQYGLRPFAELSIIAFVVASCLNLFVTDLHSAIVIRFVSGMAAAPISSLGFLYILEAFPPARKFSLGFSIALTGTLLSA
PLARIVSPSLLEIDGWNALYSMEVGFALISLAVIYVLKVTPPPRAKVIERMDILSYVLFAGGLGCLAVMLTLGRFYWWFE
TWWLGALLATSIALLTLMAFIELPRKNPLLDLRWIFSKTNLHVMAVLLIYRAVSSEQSSTAVSFYQQLGLLNDQTTTLYA
LVLLATVLGGAACAWLMLSKYVDTAHVIALTLIAAGSFLDSQSTNMTRPEQMYFSQMMIAFGAAMFLPPVMAKGFAAALG
RGAPYLVNFIAIFLFTQITGSMLMTGLLGSFVTLREKFHSNILVENILLTNPLVAQRVSQLSGAYSHVITDPALLKAEGL
TLLAQQVSREAYVLAYNDTFLLISVVSALALAVLLIHLVWMRVRPFLSREKTDTAPALQS

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 59058; Mature: 59058

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure
MVEAAIPAAPQPVERPLWLRLCFIFAGLSFFITQGLGMNLVMANIYQLQGEFSATVAEVA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHH
WLSAAYMAPYATFSIALFKVRAQYGLRPFAELSIIAFVVASCLNLFVTDLHSAIVIRFVS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMAAAPISSLGFLYILEAFPPARKFSLGFSIALTGTLLSAPLARIVSPSLLEIDGWNALY
HHHHCCHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHH
SMEVGFALISLAVIYVLKVTPPPRAKVIERMDILSYVLFAGGLGCLAVMLTLGRFYWWFE
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TWWLGALLATSIALLTLMAFIELPRKNPLLDLRWIFSKTNLHVMAVLLIYRAVSSEQSST
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
AVSFYQQLGLLNDQTTTLYALVLLATVLGGAACAWLMLSKYVDTAHVIALTLIAAGSFLD
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SQSTNMTRPEQMYFSQMMIAFGAAMFLPPVMAKGFAAALGRGAPYLVNFIAIFLFTQITG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
SMLMTGLLGSFVTLREKFHSNILVENILLTNPLVAQRVSQLSGAYSHVITDPALLKAEGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCH
TLLAQQVSREAYVLAYNDTFLLISVVSALALAVLLIHLVWMRVRPFLSREKTDTAPALQS
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA