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The map label for this gene is emrA [H]

Identifier: 159184608

GI number: 159184608

Start: 1078706

End: 1079773

Strand: Direct

Name: emrA [H]

Synonym: Atu1087

Alternate gene names: 159184608

Gene position: 1078706-1079773 (Clockwise)

Preceding gene: 159184607

Following gene: 159184611

Centisome position: 37.96

GC content: 62.08

Gene sequence:

>1068_bases
ATGCTGAAGAAGTTTTTTACCCCCGTTTCCATCCTCGTGCTGCTCGGCGGCATCGCCGGCGTTGCGCTGGTGCTTTACGC
CTGGCGGCTGCCGCCTTTCCTGTCCACCGTCGAAATGACCGACAACGCCTTCGTGCGCGGTTATGTGACGACCATGAGCC
CGCAGGTCAGCGGTTATGTCGTCAATGTCCCGGTGAAGGACTATCAGGAAGTCAAGCAGGGGACGCTGCTGGCCAAGATC
GATGACCGCATCTACCACCAGAAACAGGCGCAGGCGGAAGCCACGCTCGATACCCACAAGGCAGCACTCGACAATTCCCG
CCAGCAGGAAAATGCCGCCAATGCCAATATCCGCTCCAGCGAGGCGGCTGTCGACAGTGCCGAAGCCTCACTGAAGCAGG
CGCAGCTCGCCTCCGACCGGCAGGATAATCTGATCAAGAGCGGCGTCGGAACTTCCAGCCTTCAGGAAGAAGCCCATGCG
GCGCTTGAAAAGGCGCGCGCATCACTGTCCCAGGCGAAAGCGGCGCTCGAGGTTTCCCGTCAGGATTTGCAGACCATCAT
CGTCAACCGCAGCTCGTTACAGGCGGCCGTCGCCAATGCCGAGGCCGCCGTTGAACTCGCCCGCATCGATCTTGCCAATA
CCGAGATTCGCGCGCCGGTGGATGGCAGGCTCGGCGAAGTCGGCGTGCGCACCGGCCAATATGTCACCGCTGGCACGCAA
CTGATGGCCGTCGTTCCGCATGATGTCTGGGTTATCGCCAATTTCAAGGAGACCCAGCTCGCCGGTATGCAGGTGGGCCA
GCCGGTGACGATTTCGGTCGATGCGCTGCATCGCCGCAAGCTGACCGGCCATGTGGAGCGCTTTTCGCCCGCCACCGGCT
CGGAATTCGCCGTCATCAAGCCCGACAATGCGACCGGCAATTTCGTGAAGATCGCCCAGCGTCTCGGCGTGCGGATCGTG
ATCGATGCGGATCAGCCGCTCGCGGCGGAGCTTTCGCCTGGTATGTCGGTGGTGGTGCATCTGGACAAGAGCAAGGCGCC
TGATGGGGCGGAGACGGCGGCGAAGTAG

Upstream 100 bases:

>100_bases
TTAATCCACCTTGTCTGGATGCGTGTCCGACCTTTCCTGTCGCGGGAAAAGACCGATACTGCGCCGGCGCTACAGTCATG
AAAATTCCAAGAGTGACAAA

Downstream 100 bases:

>100_bases
TTGGTAAAGGTTGGAGGGTGTGGTTTATACCCCCCTCTGTCCTGCCGGACATCTCCCCCTCAAGGGGGGAGATCGACTCG
TGGATAGGGCTCGCCCATCT

Product: secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MLKKFFTPVSILVLLGGIAGVALVLYAWRLPPFLSTVEMTDNAFVRGYVTTMSPQVSGYVVNVPVKDYQEVKQGTLLAKI
DDRIYHQKQAQAEATLDTHKAALDNSRQQENAANANIRSSEAAVDSAEASLKQAQLASDRQDNLIKSGVGTSSLQEEAHA
ALEKARASLSQAKAALEVSRQDLQTIIVNRSSLQAAVANAEAAVELARIDLANTEIRAPVDGRLGEVGVRTGQYVTAGTQ
LMAVVPHDVWVIANFKETQLAGMQVGQPVTISVDALHRRKLTGHVERFSPATGSEFAVIKPDNATGNFVKIAQRLGVRIV
IDADQPLAAELSPGMSVVVHLDKSKAPDGAETAAK

Sequences:

>Translated_355_residues
MLKKFFTPVSILVLLGGIAGVALVLYAWRLPPFLSTVEMTDNAFVRGYVTTMSPQVSGYVVNVPVKDYQEVKQGTLLAKI
DDRIYHQKQAQAEATLDTHKAALDNSRQQENAANANIRSSEAAVDSAEASLKQAQLASDRQDNLIKSGVGTSSLQEEAHA
ALEKARASLSQAKAALEVSRQDLQTIIVNRSSLQAAVANAEAAVELARIDLANTEIRAPVDGRLGEVGVRTGQYVTAGTQ
LMAVVPHDVWVIANFKETQLAGMQVGQPVTISVDALHRRKLTGHVERFSPATGSEFAVIKPDNATGNFVKIAQRLGVRIV
IDADQPLAAELSPGMSVVVHLDKSKAPDGAETAAK
>Mature_355_residues
MLKKFFTPVSILVLLGGIAGVALVLYAWRLPPFLSTVEMTDNAFVRGYVTTMSPQVSGYVVNVPVKDYQEVKQGTLLAKI
DDRIYHQKQAQAEATLDTHKAALDNSRQQENAANANIRSSEAAVDSAEASLKQAQLASDRQDNLIKSGVGTSSLQEEAHA
ALEKARASLSQAKAALEVSRQDLQTIIVNRSSLQAAVANAEAAVELARIDLANTEIRAPVDGRLGEVGVRTGQYVTAGTQ
LMAVVPHDVWVIANFKETQLAGMQVGQPVTISVDALHRRKLTGHVERFSPATGSEFAVIKPDNATGNFVKIAQRLGVRIV
IDADQPLAAELSPGMSVVVHLDKSKAPDGAETAAK

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=352, Percent_Identity=32.1022727272727, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789041, Length=346, Percent_Identity=33.8150289017341, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790519, Length=332, Percent_Identity=29.5180722891566, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87081951, Length=325, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789637, Length=333, Percent_Identity=26.7267267267267, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37951; Mature: 37951

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKFFTPVSILVLLGGIAGVALVLYAWRLPPFLSTVEMTDNAFVRGYVTTMSPQVSGYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEEEEEEECCCCCCEE
VNVPVKDYQEVKQGTLLAKIDDRIYHQKQAQAEATLDTHKAALDNSRQQENAANANIRSS
EECCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
EAAVDSAEASLKQAQLASDRQDNLIKSGVGTSSLQEEAHAALEKARASLSQAKAALEVSR
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDLQTIIVNRSSLQAAVANAEAAVELARIDLANTEIRAPVDGRLGEVGVRTGQYVTAGTQ
HHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCCCCCCCCCCCCEEECCCE
LMAVVPHDVWVIANFKETQLAGMQVGQPVTISVDALHRRKLTGHVERFSPATGSEFAVIK
EEEEECCCEEEEECCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEC
PDNATGNFVKIAQRLGVRIVIDADQPLAAELSPGMSVVVHLDKSKAPDGAETAAK
CCCCCCHHHHHHHHCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCCHHCCC
>Mature Secondary Structure
MLKKFFTPVSILVLLGGIAGVALVLYAWRLPPFLSTVEMTDNAFVRGYVTTMSPQVSGYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCCEEEEEEEEECCCCCCEE
VNVPVKDYQEVKQGTLLAKIDDRIYHQKQAQAEATLDTHKAALDNSRQQENAANANIRSS
EECCHHHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
EAAVDSAEASLKQAQLASDRQDNLIKSGVGTSSLQEEAHAALEKARASLSQAKAALEVSR
HHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDLQTIIVNRSSLQAAVANAEAAVELARIDLANTEIRAPVDGRLGEVGVRTGQYVTAGTQ
HHHHHHHHCCHHHHHHHHHHHHHHEEEEEEECCCEEECCCCCCCCCCCCCCCCEEECCCE
LMAVVPHDVWVIANFKETQLAGMQVGQPVTISVDALHRRKLTGHVERFSPATGSEFAVIK
EEEEECCCEEEEECCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEC
PDNATGNFVKIAQRLGVRIVIDADQPLAAELSPGMSVVVHLDKSKAPDGAETAAK
CCCCCCHHHHHHHHCCEEEEEECCCCCHHHCCCCCEEEEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]