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The map label for this gene is dfp [H]

Identifier: 159184253

GI number: 159184253

Start: 309110

End: 310315

Strand: Direct

Name: dfp [H]

Synonym: Atu0316

Alternate gene names: 159184253

Gene position: 309110-310315 (Clockwise)

Preceding gene: 15887665

Following gene: 15887667

Centisome position: 10.88

GC content: 61.11

Gene sequence:

>1206_bases
ATGACGCTTTCAGGCAAACATATTCTCCTCATCATCTCCGGCGGCATCGCAGCCTATAAGAGCCTCGATCTCATCCGCCG
CCTGAAAGAGCGCGGCGCGAAGGTGACACCTGTCATGACCAAGGGTGCTCAGGAATTCGTCACTCCGCTTGCCGTCGGCG
CGCTTTCAGCCAGCAATGTCTTCACCGAGATTTTTTCCAGGCAGGACGAGCAGGATGTCGGCCATATCAGGCTGGCGCGC
GACTGCGATCTCGTGCTGGTGGCGCCCGCCACCGCCGATCTGATGGCGAAGATGGCGAATGGCTTGGCTGACGATCTTGC
CTCCGCAGTCCTTCTCGCGACGGATCGCAAGGTGCTTGTTGCACCGGCCATGAATCCGAAAATGTGGTCGGCAAAGCCAA
CGATGCGCAATGTCGAAACGCTGAAGAGGGATGGCGTGTTTTTCATCGGGCCCATGGCCGGCGAGATGGCGGAGACGGGC
GAGGCTGGCCTTGGCCGCATGGCGGAGCCTTTGCAGATCGTCGAAGCCGTCTTATCGCTGCTGGATGGCAGCTCGAAGCC
GCTCAAAGGCAAAACGGCGATCGTCACTTCCGGGCCTACGCATGAGCCGATCGATCCGGTGCGGTATATTGCCAACCGCT
CTTCCGGCAAGCAGGGTCATGCCATCGCAGCGGCTCTCGCGGCACTGGGCGCGGAGGTCACGCTGGTTTCCGGCCCCGTC
ACCATCGCCGATCCCGCCGGGGTGACAACGATCCATGTCGAGCGCGCAGAAGAGATGCGCGATGCGGTGATCTCTAGGCT
TCCTGCGGATATCGCCGTCATGGTCGCCGCGGTTGCCGACTGGCGGGTGACAGGTTCCTCGGAACAAAAGATCAAGAAGC
AGCCGGGCGATGCGCCGCCGGCGCTGCAGCTGACGGAGAATCCGGATATTCTCAAGACCGTCGGCCACCATGAAAAGCGC
CCCAGGGTGGTGGTGGGTTTCGCCGCCGAAACGCAGGATGTGGAGAAAAACGGCCGCGCCAAGCTGGAGCGTAAGGGTGC
GGATTATATCATCGCCAACGATGTATCGGCAGAAACCGGCATCATGGGCGGAGACCGCAACAGCGTGAAGATCATTTCGG
CCGATGGTGTCGAGGCCTGGCCGGATCTCGACAAGGCGGAAGTCGCAAAACGTCTGGCAGCCCTTATCGCGGAGAAACTC
GCATGA

Upstream 100 bases:

>100_bases
CAAGGAATATCACGTCGCCAAGGCGGCGTGATATCAGCCGGATTGCACTTTGAATGCCAAGGGCTTAGTTTCCCCGTAAA
CGGGAAACTGGTCCGGCATC

Downstream 100 bases:

>100_bases
CCCTCTTTGATCGCAAGACATTCGACAGGGTGCTTGGCGAATGGCCGGGCGTGCGTTTCGTCGATCAATGGGATTCACAT
GTGGCCAAGGTGGGCGACAA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNVFTEIFSRQDEQDVGHIRLAR
DCDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLVAPAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETG
EAGLGRMAEPLQIVEAVLSLLDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPV
TIADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPPALQLTENPDILKTVGHHEKR
PRVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETGIMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKL
A

Sequences:

>Translated_401_residues
MTLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNVFTEIFSRQDEQDVGHIRLAR
DCDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLVAPAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETG
EAGLGRMAEPLQIVEAVLSLLDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPV
TIADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPPALQLTENPDILKTVGHHEKR
PRVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETGIMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKL
A
>Mature_400_residues
TLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNVFTEIFSRQDEQDVGHIRLARD
CDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLVAPAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETGE
AGLGRMAEPLQIVEAVLSLLDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPVT
IADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPPALQLTENPDILKTVGHHEKRP
RVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETGIMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKLA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=36.6666666666667, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=44.5569620253165, Blast_Score=274, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17560194, Length=188, Percent_Identity=34.0425531914894, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657262, Length=184, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42355; Mature: 42224

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNV
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCHHHHHHHHHHHHHHHHHH
FTEIFSRQDEQDVGHIRLARDCDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLV
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
APAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETGEAGLGRMAEPLQIVEAVLSL
ECCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
LDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPV
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECCE
TIADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPP
EEECCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEECCCCHHHHHHCCCCCCC
ALQLTENPDILKTVGHHEKRPRVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETG
CEEECCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHCCCHHHHHCCCCEEEEECCCCCCC
IMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKLA
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNV
CCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCHHHHHHHHHHHHHHHHHH
FTEIFSRQDEQDVGHIRLARDCDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLV
HHHHHCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHEECCCEEEE
APAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETGEAGLGRMAEPLQIVEAVLSL
ECCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
LDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPV
HCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEEECCE
TIADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPP
EEECCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEECCCCHHHHHHCCCCCCC
ALQLTENPDILKTVGHHEKRPRVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETG
CEEECCCCCHHHHHCCCCCCCEEEEEECCCCHHHHHCCCHHHHHCCCCEEEEECCCCCCC
IMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKLA
CCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA