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The map label for this gene is dop [H]

Identifier: 15888320

GI number: 15888320

Start: 966101

End: 967672

Strand: Direct

Name: dop [H]

Synonym: Atu0977

Alternate gene names: 15888320

Gene position: 966101-967672 (Clockwise)

Preceding gene: 159184558

Following gene: 15888321

Centisome position: 34.0

GC content: 62.72

Gene sequence:

>1572_bases
ATGTCTCATTCGCAAAACGGCCATTCCTCGCTGAAGACGGCCTCGCTGAAGACGGCCCTGAAGGCCACGACCGTTGGCGG
CCTCGCGGCGCTGATGCTGTCGACCGGTATCGCCGCACCGATCCTCCACTCCTTTGCTGCCCCCGTCGAAGTGACCGCAC
CGCAGGTTCCGAGCTTCGCCAATGTGGTTGATGCCGTCTCGCCCGCCGTCGTTTCCGTTCGCGTGCAGTCGAACGTGCAG
CCGGCTTCCGACGATTCCAGCAACTTCTCCTTCAATTTCGGCGGCCGCGGCCTCGACCAGCTGCCGGATGATCACCCGCT
GAAGCGTTTCTTCAAGGAATTCGGCGGCCAGAACCAGGATCGCTCCGACCGTGGTCCGAACCGCCACCGTGACGGCAAGG
GTCCGCTGCGCCCGGTCGCGCAAGGCTCCGGCTTCTTCATCTCCGAAGACGGTTATGTCGTCACCAACAATCACGTCGTT
GACGACGGTTCCGCCTATACGGTCGTGATGAATGACGGTACCGAACTCGAAGCCAAGCTTGTCGGCCGCGATCCGCGTAC
CGATCTGGCGCTGCTGAAGGTCGATGTGAACCGCAAGTTCACCTATGTGAAATTCGCCGATGACACCAAGATTCGCGTCG
GTGACTGGGTCGTTGCCGTCGGTAACCCCTTCGGCCTCGGCGGTACGGTGACGTCAGGTATCATTTCGGCCCGCGGCCGT
GACATCGGCTCAGGCCCCTATGACGACTATCTGCAGATCGACGCTGCCGTGAACCGTGGTAACTCGGGTGGTCCCGCCTT
CAACCTTAACGGTGAAGTGGTGGGCATCAACACCGCCATCTTCTCGCCCTCCGGCGGCAATGTCGGTATCGCCTTCGCCA
TCCCGTCCTCGGTCGCCAAGGATGTGATCGCCGACCTGCAAAAGGACGGCAAGGTCGAACGCGGCTGGCTCGGCGTGCAG
ATCCAGCCCGTCAGCAAGGATATCGCCGAATCGCTCGGCCTTGCCGAAGCCAAGGGCGCGCTGGTCGTTTCGCCGCAGTC
CGGTTCTCCGGGCGACAAGGCCGGCATCAAGCAGGGTGACATCATCACCGCCGTCAACGGCGATCCGGTCAAGGATGCCC
GCGATCTGTCGCGCCGCATCGGCGGCATGGCGCCCAACAGCAAGGTTGAAATCTCGCTGTGGCGTGGCGGCAAGTCGCAG
TCCGTGACGGTGACGCTCGGTGATCTCACCAGCGATGAAGCCTCCAAGGCGACGCCAAGCCAGAACGATGACAAGGGCGG
CAGCCAGTCCTCCAGCGAGAAGGTGCTGTCCAGCCTCGGCCTGACGGTTTCGCCTTCCGATGACGGCAACGGCCTTGCCA
TCACCGATGTCGACCCCGATAGCGACGCCGCTGCCCGGGGCCTGAAGACGGGCGAGAAGATCACCTCGGTCAACAACCAG
CAGGTGGCTTCCGCAGCTGATATCGAGAAGATCCTCGAGCAGGCCAAGAAGGACGGACGTTCCAAGGCGCTGTTCCAGAT
CCAGACGGATGACGGCAGCCGCTTCATCGCGCTGGATATCGACCAGGGTTGA

Upstream 100 bases:

>100_bases
CTCAGACACTTCGCCGTAAGGTGTTGCCTCCTATATCTTCATCATCCACCGCTTCCCCGGTCACACGGGTTCCAGTCTGA
ATGAAGAAAGAAGGTACACC

Downstream 100 bases:

>100_bases
TAGGCTGAAATGCGATGCCGGCTTCCTTGGGAGGCCGGCGCCGCCCCAGACTATGTCTTGGCTTTAAGGCGGGACAAAGC
ATGTGGAACGAGCCCTCGCC

Product: serine protease DO-like protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSHSQNGHSSLKTASLKTALKATTVGGLAALMLSTGIAAPILHSFAAPVEVTAPQVPSFANVVDAVSPAVVSVRVQSNVQ
PASDDSSNFSFNFGGRGLDQLPDDHPLKRFFKEFGGQNQDRSDRGPNRHRDGKGPLRPVAQGSGFFISEDGYVVTNNHVV
DDGSAYTVVMNDGTELEAKLVGRDPRTDLALLKVDVNRKFTYVKFADDTKIRVGDWVVAVGNPFGLGGTVTSGIISARGR
DIGSGPYDDYLQIDAAVNRGNSGGPAFNLNGEVVGINTAIFSPSGGNVGIAFAIPSSVAKDVIADLQKDGKVERGWLGVQ
IQPVSKDIAESLGLAEAKGALVVSPQSGSPGDKAGIKQGDIITAVNGDPVKDARDLSRRIGGMAPNSKVEISLWRGGKSQ
SVTVTLGDLTSDEASKATPSQNDDKGGSQSSSEKVLSSLGLTVSPSDDGNGLAITDVDPDSDAAARGLKTGEKITSVNNQ
QVASAADIEKILEQAKKDGRSKALFQIQTDDGSRFIALDIDQG

Sequences:

>Translated_523_residues
MSHSQNGHSSLKTASLKTALKATTVGGLAALMLSTGIAAPILHSFAAPVEVTAPQVPSFANVVDAVSPAVVSVRVQSNVQ
PASDDSSNFSFNFGGRGLDQLPDDHPLKRFFKEFGGQNQDRSDRGPNRHRDGKGPLRPVAQGSGFFISEDGYVVTNNHVV
DDGSAYTVVMNDGTELEAKLVGRDPRTDLALLKVDVNRKFTYVKFADDTKIRVGDWVVAVGNPFGLGGTVTSGIISARGR
DIGSGPYDDYLQIDAAVNRGNSGGPAFNLNGEVVGINTAIFSPSGGNVGIAFAIPSSVAKDVIADLQKDGKVERGWLGVQ
IQPVSKDIAESLGLAEAKGALVVSPQSGSPGDKAGIKQGDIITAVNGDPVKDARDLSRRIGGMAPNSKVEISLWRGGKSQ
SVTVTLGDLTSDEASKATPSQNDDKGGSQSSSEKVLSSLGLTVSPSDDGNGLAITDVDPDSDAAARGLKTGEKITSVNNQ
QVASAADIEKILEQAKKDGRSKALFQIQTDDGSRFIALDIDQG
>Mature_522_residues
SHSQNGHSSLKTASLKTALKATTVGGLAALMLSTGIAAPILHSFAAPVEVTAPQVPSFANVVDAVSPAVVSVRVQSNVQP
ASDDSSNFSFNFGGRGLDQLPDDHPLKRFFKEFGGQNQDRSDRGPNRHRDGKGPLRPVAQGSGFFISEDGYVVTNNHVVD
DGSAYTVVMNDGTELEAKLVGRDPRTDLALLKVDVNRKFTYVKFADDTKIRVGDWVVAVGNPFGLGGTVTSGIISARGRD
IGSGPYDDYLQIDAAVNRGNSGGPAFNLNGEVVGINTAIFSPSGGNVGIAFAIPSSVAKDVIADLQKDGKVERGWLGVQI
QPVSKDIAESLGLAEAKGALVVSPQSGSPGDKAGIKQGDIITAVNGDPVKDARDLSRRIGGMAPNSKVEISLWRGGKSQS
VTVTLGDLTSDEASKATPSQNDDKGGSQSSSEKVLSSLGLTVSPSDDGNGLAITDVDPDSDAAARGLKTGEKITSVNNQQ
VASAADIEKILEQAKKDGRSKALFQIQTDDGSRFIALDIDQG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=282, Percent_Identity=36.1702127659575, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI24308541, Length=260, Percent_Identity=34.2307692307692, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI22129776, Length=268, Percent_Identity=35.0746268656716, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7019477, Length=284, Percent_Identity=33.4507042253521, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1786356, Length=472, Percent_Identity=37.5, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1789629, Length=478, Percent_Identity=38.9121338912134, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1789630, Length=289, Percent_Identity=35.6401384083045, Blast_Score=165, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6324206, Length=299, Percent_Identity=28.0936454849498, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24646839, Length=295, Percent_Identity=32.8813559322034, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 54437; Mature: 54306

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSQNGHSSLKTASLKTALKATTVGGLAALMLSTGIAAPILHSFAAPVEVTAPQVPSFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHH
NVVDAVSPAVVSVRVQSNVQPASDDSSNFSFNFGGRGLDQLPDDHPLKRFFKEFGGQNQD
HHHHHCCCEEEEEEEECCCCCCCCCCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCC
RSDRGPNRHRDGKGPLRPVAQGSGFFISEDGYVVTNNHVVDDGSAYTVVMNDGTELEAKL
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEE
VGRDPRTDLALLKVDVNRKFTYVKFADDTKIRVGDWVVAVGNPFGLGGTVTSGIISARGR
ECCCCCCCEEEEEEECCCEEEEEEECCCCEEEECCEEEECCCCCCCCHHHHHHHHHHCCC
DIGSGPYDDYLQIDAAVNRGNSGGPAFNLNGEVVGINTAIFSPSGGNVGIAFAIPSSVAK
CCCCCCCCCCEEEEEEECCCCCCCCEEECCCEEEEEEEEEECCCCCCEEEEEECCHHHHH
DVIADLQKDGKVERGWLGVQIQPVSKDIAESLGLAEAKGALVVSPQSGSPGDKAGIKQGD
HHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
IITAVNGDPVKDARDLSRRIGGMAPNSKVEISLWRGGKSQSVTVTLGDLTSDEASKATPS
EEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCC
QNDDKGGSQSSSEKVLSSLGLTVSPSDDGNGLAITDVDPDSDAAARGLKTGEKITSVNNQ
CCCCCCCCCCHHHHHHHHCCCEECCCCCCCEEEEEECCCCCHHHHHCCCCCHHHHCCCCH
QVASAADIEKILEQAKKDGRSKALFQIQTDDGSRFIALDIDQG
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCC
>Mature Secondary Structure 
SHSQNGHSSLKTASLKTALKATTVGGLAALMLSTGIAAPILHSFAAPVEVTAPQVPSFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHH
NVVDAVSPAVVSVRVQSNVQPASDDSSNFSFNFGGRGLDQLPDDHPLKRFFKEFGGQNQD
HHHHHCCCEEEEEEEECCCCCCCCCCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCC
RSDRGPNRHRDGKGPLRPVAQGSGFFISEDGYVVTNNHVVDDGSAYTVVMNDGTELEAKL
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECCEEEECCCEEEEEECCCCEEEEEE
VGRDPRTDLALLKVDVNRKFTYVKFADDTKIRVGDWVVAVGNPFGLGGTVTSGIISARGR
ECCCCCCCEEEEEEECCCEEEEEEECCCCEEEECCEEEECCCCCCCCHHHHHHHHHHCCC
DIGSGPYDDYLQIDAAVNRGNSGGPAFNLNGEVVGINTAIFSPSGGNVGIAFAIPSSVAK
CCCCCCCCCCEEEEEEECCCCCCCCEEECCCEEEEEEEEEECCCCCCEEEEEECCHHHHH
DVIADLQKDGKVERGWLGVQIQPVSKDIAESLGLAEAKGALVVSPQSGSPGDKAGIKQGD
HHHHHHHHCCCCCCCEEEEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCC
IITAVNGDPVKDARDLSRRIGGMAPNSKVEISLWRGGKSQSVTVTLGDLTSDEASKATPS
EEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCC
QNDDKGGSQSSSEKVLSSLGLTVSPSDDGNGLAITDVDPDSDAAARGLKTGEKITSVNNQ
CCCCCCCCCCHHHHHHHHCCCEECCCCCCCEEEEEECCCCCHHHHHCCCCCHHHHCCCCH
QVASAADIEKILEQAKKDGRSKALFQIQTDDGSRFIALDIDQG
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]