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The map label for this gene is ragA [H]

Identifier: 15888321

GI number: 15888321

Start: 967945

End: 968703

Strand: Direct

Name: ragA [H]

Synonym: Atu0978

Alternate gene names: 15888321

Gene position: 967945-968703 (Clockwise)

Preceding gene: 15888320

Following gene: 159184559

Centisome position: 34.06

GC content: 59.82

Gene sequence:

>759_bases
ATGGAAAACAAGGTTCAGGAAATGTCTGTCACATCTCTTTCCGGTTGTGCGGAAAAGGGCGACGGCGCTATTGTCCCGCA
CATGAAGATTCTTGTCATTGAAGACGACCTCGAGGCTGCGGCCTATATGACCAAGGCGTTCCGCGAAGCCGGAATTGTCG
CCGACCATGCCAGCGATGGCGAGAGCGGTTTGTTCATGGGCTGCGAGAATGCCTACGACGTACTGGTGATCGACCGCATG
CTGCCGCGACGCGACGGGCTTTCGGTCATCAGCGAGCTGCGCCGCCGCGGTATCGAGACGCCGGTGCTGATCCTTTCCGC
ATTGGGCCAGGTCGATGACCGCGTGACCGGCCTGCGCGCCGGCGGCGATGATTACCTGCCGAAACCCTATGCCTTTTCCG
AACTGCTCGCCCGCATCGAGGTGCTCGGCCGCCGCAAGGGCAAGCCCGAGCAGGACATGATCTACCGCGTGGGTGATCTC
GAACTCGACCGCCTGTCGCACGATGTCCGCCGCGGCGGCAAGGAAATCCTGCTGCAGCCGCGCGAATTCCGGCTGCTGGA
ATATCTGATGAAGAATGCCGGCCAGGTGGTGACCCGCACCATGCTGCTGGAAAATGTCTGGGATTATCATTTCGACCCGC
AGACCAATGTCATCGACGTCCATGTTTCCCGCCTGCGCTCGAAGATCGAGAAGGACTTCGAGAAACCGCTCTTGAAGACC
ATTCGCGGTGCCGGTTACATGATGAAGGACGAGGGCTGA

Upstream 100 bases:

>100_bases
AACGTGACCCCCTCATCCGACCCTTCGGGCCACCCTCTCCCCGGCGGGGAGGAGAAAGGACCGGCAACCCCGGTCAAGGC
AGCACCGCGGAGGAAACCTC

Downstream 100 bases:

>100_bases
TTGGCGAAAATGGCCCGCCTCAGAATATTGTTCAGATCGACAGCGGTGCGCCTTTCGGCGCTCTATATCCTGCTCTTCGC
ACTCTGCGCCGCCTTCCTCG

Product: two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MENKVQEMSVTSLSGCAEKGDGAIVPHMKILVIEDDLEAAAYMTKAFREAGIVADHASDGESGLFMGCENAYDVLVIDRM
LPRRDGLSVISELRRRGIETPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARIEVLGRRKGKPEQDMIYRVGDL
ELDRLSHDVRRGGKEILLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFEKPLLKT
IRGAGYMMKDEG

Sequences:

>Translated_252_residues
MENKVQEMSVTSLSGCAEKGDGAIVPHMKILVIEDDLEAAAYMTKAFREAGIVADHASDGESGLFMGCENAYDVLVIDRM
LPRRDGLSVISELRRRGIETPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARIEVLGRRKGKPEQDMIYRVGDL
ELDRLSHDVRRGGKEILLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFEKPLLKT
IRGAGYMMKDEG
>Mature_252_residues
MENKVQEMSVTSLSGCAEKGDGAIVPHMKILVIEDDLEAAAYMTKAFREAGIVADHASDGESGLFMGCENAYDVLVIDRM
LPRRDGLSVISELRRRGIETPVLILSALGQVDDRVTGLRAGGDDYLPKPYAFSELLARIEVLGRRKGKPEQDMIYRVGDL
ELDRLSHDVRRGGKEILLQPREFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFEKPLLKT
IRGAGYMMKDEG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=43.2432432432432, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=40.6392694063927, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=36, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=37.3333333333333, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=33.1818181818182, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=32.7272727272727, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=29.7297297297297, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=30.4721030042918, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.5263157894737, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.6742081447964, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=29.0178571428571, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=31.1965811965812, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=27.7056277056277, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.936170212766, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=29.7297297297297, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28395; Mature: 28395

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENKVQEMSVTSLSGCAEKGDGAIVPHMKILVIEDDLEAAAYMTKAFREAGIVADHASDG
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCC
ESGLFMGCENAYDVLVIDRMLPRRDGLSVISELRRRGIETPVLILSALGQVDDRVTGLRA
CCCEEEECCCCCHHEEHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GGDDYLPKPYAFSELLARIEVLGRRKGKPEQDMIYRVGDLELDRLSHDVRRGGKEILLQP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHCCCHHEECCC
REFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFEKPLLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRGAGYMMKDEG
HHCCCCEECCCC
>Mature Secondary Structure
MENKVQEMSVTSLSGCAEKGDGAIVPHMKILVIEDDLEAAAYMTKAFREAGIVADHASDG
CCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEECCCCC
ESGLFMGCENAYDVLVIDRMLPRRDGLSVISELRRRGIETPVLILSALGQVDDRVTGLRA
CCCEEEECCCCCHHEEHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
GGDDYLPKPYAFSELLARIEVLGRRKGKPEQDMIYRVGDLELDRLSHDVRRGGKEILLQP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEECCCCCHHHHHHHHHHCCCHHEECCC
REFRLLEYLMKNAGQVVTRTMLLENVWDYHFDPQTNVIDVHVSRLRSKIEKDFEKPLLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRGAGYMMKDEG
HHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]