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The map label for this gene is hemN [H]

Identifier: 57651976

GI number: 57651976

Start: 1670210

End: 1671367

Strand: Reverse

Name: hemN [H]

Synonym: SACOL1640

Alternate gene names: 57651976

Gene position: 1671367-1670210 (Counterclockwise)

Preceding gene: 57651977

Following gene: 57651975

Centisome position: 59.49

GC content: 32.82

Gene sequence:

>1158_bases
TTGGATAAAAAGTCTGAGAAGCGGGGCATTAAAATGACGGTACAAAGTGCATATATACATATTCCATTTTGTGTAAGAAT
ATGTACATATTGTGATTTCAATAAATATTTTATACAGAATCAACCTGTAGATGAGTACTTAGATGCACTAATCACAGAAA
TGTCTACAGCAAAATATAGGATCTTAAAGACCATGTATGTAGGTGGCGGCACACCAACGGCCCTTTCTATTAATCAGTTG
GAAAGATTACTTAAAGCAATACGTGATACGTTTACAATCACAGGCGAGTATACATTTGAAGCAAATCCTGATGAGTTAAC
TAAAGAGAAAGTCCAACTATTAGAGAAATATGGAGTAAAAAGGATTTCAATGGGCGTTCAAACATTCAAGCCGGAGTTAT
TGTCTGTTTTAGGTAGAACGCACAATACTGAAGATATTTACACTTCGGTGTTAAATGCTAAAAACGCAGGTATTAAATCA
ATCAGTTTAGATTTAATGTATCATTTACCGAAACAGACGATTGAAGATTTTGAACAAAGTTTAGATCTAGCTTTAGATAT
GGATATTCAACATATTTCGAGTTACGGCTTAATACTTGAACCTAAAACCCAATTTTATAATATGTATAGAAAAGGCTTGC
TCAAACTTCCTAATGAGGATTTAGGTGCTGACATGTATCAGTTGCTGATGTCTAAGATAGAACAATCTCCTTTCCATCAA
TACGAAATATCTAATTTTGCATTAGATGGCCATGAATCAGAACATAATAAGGTTTACTGGTTTAATGAGGAATATTATGG
ATTTGGAGCAGGTGCAAGTGGTTATGTAGATGGTGTGCGTTATACGAATATCAATCCAGTGAATCATTATATCAAAGCTA
TAAATAAAGAAAGTAAAGCAATTTTAGTATCAAATAAACCTTCTTTGACTGAGAGAATGGAAGAAGAAATGTTTCTTGGG
TTGCGTTTAAATGAAGGTGTGAGTAGTAGTAGGTTCAAAAAGAAGTTTGACCAATCTATTGAAAGTGTCTTTGGTCAAAC
AATAAATAATTTAAAAGAGAAGGAATTAATTGTAGAAAAGAACGATGTGATTGCACTTACAAATAGAGGGAAAGTCATAG
GTAATGAGGTTTTTGAAGCTTTCCTAATAAATGATTAA

Upstream 100 bases:

>100_bases
GAATAAATATTAAAATGAATCGATATATTAGACAATCATTGATTAAACGTTAAAGTTAAAAGTAAGAATAATTGCAGATA
GTCCAACAGGATATAGCCGA

Downstream 100 bases:

>100_bases
AAAAATTGAAATTTCGAGTCTTTAACATTGACTTACTTTGACCAATTTGATAAATTATAATTAGCACTTGAGATAAGTGA
GTGCTAATGAGGTGAAAACA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQL
ERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKS
ISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLG
LRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND

Sequences:

>Translated_385_residues
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQL
ERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKS
ISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLG
LRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND
>Mature_385_residues
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQL
ERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKS
ISLDLMYHLPKQTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLG
LRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=33.4600760456274, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789325, Length=387, Percent_Identity=31.5245478036176, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87082341, Length=388, Percent_Identity=25.2577319587629, Blast_Score=121, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44169; Mature: 44169

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYR
CCCCCCCCCCEEEEEEEEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
ILKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVK
HHHHEEECCCCCCEEEHHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHCCH
RISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHCCHHHHHHHHHH
LDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
HCEEECCCHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCE
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKA
EECCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCE
ILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEK
EEEECCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
NDVIALTNRGKVIGNEVFEAFLIND
CCEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MDKKSEKRGIKMTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYR
CCCCCCCCCCEEEEEEEEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHH
ILKTMYVGGGTPTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVK
HHHHEEECCCCCCEEEHHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHCCH
RISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHCCHHHHHHHHHH
LDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQ
HCEEECCCHHHHHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCE
YEISNFALDGHESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKA
EECCCEEECCCCCCCCEEEEECCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCE
ILVSNKPSLTERMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEK
EEEECCCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
NDVIALTNRGKVIGNEVFEAFLIND
CCEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]