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The map label for this gene is ubiB [C]

Identifier: 41410217

GI number: 41410217

Start: 4589711

End: 4591069

Strand: Reverse

Name: ubiB [C]

Synonym: MAP4119c

Alternate gene names: 41410217

Gene position: 4591069-4589711 (Counterclockwise)

Preceding gene: 41410218

Following gene: 41410216

Centisome position: 95.06

GC content: 67.99

Gene sequence:

>1359_bases
ATGAGCTCTACCAAACATCGAGAGGTGGCCAAGCTCGACCGGGTGCCGTTGCCGGTCGAGGCGGCCCGGGTAGCGGCGAC
CGGTTGGCAGGTCACCCGCTCCGCCGCTCGCGTCCTCACCAAGCTGCCGGCCAAGGGCCCGTGGCAGCAGAAAGTGATCA
AGCAGCTCCCCCAGACGTTCGCCGACCTGGGGCCCACCTACGTCAAGTTCGGGCAGATCATCGCGTCCAGCCCCGGCGCG
TTCGGCGAATCGCTGTCCCGGGAGTTCCGCGGCCTGTTGGACCGGGTGCCGCCCGCCGACCCCGACGAGGTGCACAAGCT
GTTCCTCGAGGAGCTCGGGGCCGACCCGTCCGAGCTGTTCGCCAGCTGGGACGAGACCCCGTTCGCCTCGGCGTCCATCG
CCCAGGTGCACTACGCCACCCTGCACACCGGCGAGGAGGTCGTCGTCAAGATCCAGCGGCCGGGCATCCGCCGCCGGGTC
GCCGCCGACCTGCAGATCCTCAAGCGCTTCGCCCAGGCCGTCGAGCTGGCCAAGCTCGGCCGCCGGCTGTCCGCCCAGGA
CGTGGTCGCCGACTTCTCCGACAACCTGGCCGAGGAGCTGAACTTCCGGCTGGAGGCCCAGTCGATGGAGGCCTGGGTGT
CGCACCTGCACGCCTCGCCGCTGGGCAAAAACATCCGGGTGCCGCAGGTGTACTGGGACTTCACCACCGACCGGGTGCTG
ACCATGGAGCGGGTGTCCGGGATCCGCATCGACGACGTCGCCGCGGTCCGCAAGGCCGGGTTCGACGGGGTTGAGCTGGT
CAAGGCGCTGCTGTTCAGCCTGTTCGAGGGCGGGCTGCGGCACGGCCTGTTCCACGGCGACCTGCACGCCGGCAACCTCT
ACGTCGACGAGGCGGGCCGCATCGTGTTCTTCGACTTCGGCATCATGGGCCGCATCGACCCGCGCACCCGCTGGCTGCTG
CGCGAGCTCGTGTATGCGCTGCTGGTCAAGAAGGACCACGCCGCGGCCGGCAAGATCGTGGTGCTGATGGGCGCCGTGGG
CACCGTGAAACCCGAAGCCCAGGCCGCCAAGGACCTGGAGAAATTCGCCACCCCGCTGACCATGCAGACCCTGGGCGACA
TGTCCTATGCCGACATCGGCCGCCAGCTGTCGGCGCTGGCCGACGCCTACGACGTCAAGCTGCCCCGCGAGCTGGTGCTG
ATCGGCAAGCAGTTCCTCTACGTCGAGCGCTACATGAAGCTGCTGGCACCCAAGTGGCAGATGATGTCGGATCCTCAACT
GACCGGGTATTTCGCCAACTTCATGGTCGAGGTCAGCCGCGAGCACTCCTCCGAGTTCGAATCCGACGTCGAGGTCTAG

Upstream 100 bases:

>100_bases
AGGGCTGGGCCATCGAGGGCTGGGTGCAGCCCTGGAAGGGCGGCGGCGATCGTCGCTAGCGGATTGGGACTCGCCAGCGC
CGATTTGGCACACTGCACTG

Downstream 100 bases:

>100_bases
GGGCCTTCGATGGTGCAGGTCCGCACGGGGCACGCCATATCAGGCGACCTGAAGCTCTACTACGAGGACATGGGCGACAT
CGACGACCCGCCGGTGCTGC

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSSTKHREVAKLDRVPLPVEAARVAATGWQVTRSAARVLTKLPAKGPWQQKVIKQLPQTFADLGPTYVKFGQIIASSPGA
FGESLSREFRGLLDRVPPADPDEVHKLFLEELGADPSELFASWDETPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRV
AADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWVSHLHASPLGKNIRVPQVYWDFTTDRVL
TMERVSGIRIDDVAAVRKAGFDGVELVKALLFSLFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLL
RELVYALLVKKDHAAAGKIVVLMGAVGTVKPEAQAAKDLEKFATPLTMQTLGDMSYADIGRQLSALADAYDVKLPRELVL
IGKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVEVSREHSSEFESDVEV

Sequences:

>Translated_452_residues
MSSTKHREVAKLDRVPLPVEAARVAATGWQVTRSAARVLTKLPAKGPWQQKVIKQLPQTFADLGPTYVKFGQIIASSPGA
FGESLSREFRGLLDRVPPADPDEVHKLFLEELGADPSELFASWDETPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRV
AADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWVSHLHASPLGKNIRVPQVYWDFTTDRVL
TMERVSGIRIDDVAAVRKAGFDGVELVKALLFSLFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLL
RELVYALLVKKDHAAAGKIVVLMGAVGTVKPEAQAAKDLEKFATPLTMQTLGDMSYADIGRQLSALADAYDVKLPRELVL
IGKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVEVSREHSSEFESDVEV
>Mature_451_residues
SSTKHREVAKLDRVPLPVEAARVAATGWQVTRSAARVLTKLPAKGPWQQKVIKQLPQTFADLGPTYVKFGQIIASSPGAF
GESLSREFRGLLDRVPPADPDEVHKLFLEELGADPSELFASWDETPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRVA
ADLQILKRFAQAVELAKLGRRLSAQDVVADFSDNLAEELNFRLEAQSMEAWVSHLHASPLGKNIRVPQVYWDFTTDRVLT
MERVSGIRIDDVAAVRKAGFDGVELVKALLFSLFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLR
ELVYALLVKKDHAAAGKIVVLMGAVGTVKPEAQAAKDLEKFATPLTMQTLGDMSYADIGRQLSALADAYDVKLPRELVLI
GKQFLYVERYMKLLAPKWQMMSDPQLTGYFANFMVEVSREHSSEFESDVEV

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=273, Percent_Identity=32.2344322344322, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI40254938, Length=248, Percent_Identity=29.8387096774194, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI217035081, Length=244, Percent_Identity=29.0983606557377, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI27363457, Length=259, Percent_Identity=30.8880308880309, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI217416386, Length=207, Percent_Identity=32.8502415458937, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI34147522, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI2367309, Length=364, Percent_Identity=29.9450549450549, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17559152, Length=339, Percent_Identity=27.7286135693215, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32565180, Length=149, Percent_Identity=32.8859060402685, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323282, Length=299, Percent_Identity=28.0936454849498, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=202, Percent_Identity=30.1980198019802, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325148, Length=252, Percent_Identity=24.6031746031746, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24662575, Length=299, Percent_Identity=29.0969899665552, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI22024280, Length=270, Percent_Identity=28.5185185185185, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859849, Length=257, Percent_Identity=28.7937743190661, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 50357; Mature: 50225

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTKHREVAKLDRVPLPVEAARVAATGWQVTRSAARVLTKLPAKGPWQQKVIKQLPQTF
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPADPDEVHKLFLEELGADPSELF
HHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
ASWDETPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRVAADLQILKRFAQAVELAKLG
HCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSAQDVVADFSDNLAEELNFRLEAQSMEAWVSHLHASPLGKNIRVPQVYWDFTTDRVL
HHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHH
TMERVSGIRIDDVAAVRKAGFDGVELVKALLFSLFEGGLRHGLFHGDLHAGNLYVDEAGR
HHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
IVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTVKPEAQAAKDLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
KFATPLTMQTLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPKWQ
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
MMSDPQLTGYFANFMVEVSREHSSEFESDVEV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSTKHREVAKLDRVPLPVEAARVAATGWQVTRSAARVLTKLPAKGPWQQKVIKQLPQTF
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ADLGPTYVKFGQIIASSPGAFGESLSREFRGLLDRVPPADPDEVHKLFLEELGADPSELF
HHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
ASWDETPFASASIAQVHYATLHTGEEVVVKIQRPGIRRRVAADLQILKRFAQAVELAKLG
HCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSAQDVVADFSDNLAEELNFRLEAQSMEAWVSHLHASPLGKNIRVPQVYWDFTTDRVL
HHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHH
TMERVSGIRIDDVAAVRKAGFDGVELVKALLFSLFEGGLRHGLFHGDLHAGNLYVDEAGR
HHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
IVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTVKPEAQAAKDLE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHH
KFATPLTMQTLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPKWQ
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHH
MMSDPQLTGYFANFMVEVSREHSSEFESDVEV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]