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The map label for this gene is hisC

Identifier: 41407392

GI number: 41407392

Start: 1383574

End: 1384770

Strand: Direct

Name: hisC

Synonym: MAP1294

Alternate gene names: 41407392

Gene position: 1383574-1384770 (Clockwise)

Preceding gene: 41407391

Following gene: 41407393

Centisome position: 28.65

GC content: 71.18

Gene sequence:

>1197_bases
GTGACCGGCCAGCGGGCCACCCCCCAACCCACGCTGGACGACCTGCCGCTGCGCGACGACCTGCGCGGCAAATCGCCTTA
CGGGGCACCGCAATTGGCGGTCCCGGTGCGGCTGAACACCAACGAGAACCCGCACCCGCCCAGCCGGGCGCTGGTGGACG
ACGTGGTGCGCTCGGTGGCGCGGGCCGCCGCGGACCTGCACCGCTACCCCGACCGGGACGCGGTGCAGCTGCGCAGCGAC
CTGGCCCGCTACCTCACCGCCCAGACCGGCGTCCAACTGGGAGTCGAAAACCTCTGGGCGGCAAACGGTTCCAACGAGAT
CCTGCAGCAGCTGCTGCAGGCGTTCGGCGGCCCCGGACGCAGCGCCATCGGGTTCGTTCCGTCCTACTCGATGCACCCCA
TCATCTCCGACGGCACCCGCACCGAATGGCTGCAGGCCGCCCGGGCCGACGACTTCAGCCTGGACGTCGACGCCGCGGTG
GCCGCCGTGACCGAGCGCACGCCCGACGTGGTGTTCGTCGCCAGCCCGAACAACCCGTCCGGGCAGAGCGTTTCGCTGTC
CGGCCTGCGCCGGCTGCTCGACGCGGCGCCGGGCATCGTGATCGTGGACGAGGCCTACGGCGAGTTCTCGTCACAGCCCA
GCGCGGTGCAGCTGGTGGGCGAGTATCCGACCAAGCTCGTCGTCACCCGCACCATGAGCAAGGCGTTCGCCTTCGCCGGC
GGCCGGCTCGGCTACCTGATCGCCACACCGGCGGTGATCGAGGCGATGCTGCTGGTGCGGTTGCCCTACCACCTGTCGTC
GGTGACCCAGGCCGCCGCGCGGGCCGCGCTGCGGCACGCCGACGACACGCTGGGCAGCGTCGCCGCGCTGATCGCCGAAC
GCGAACGCGTGTCAACAGCCTTGACCGGCATGGGTTTTCGAGTCATTCCCAGCGACGCCAACTTCGTGCTGTTCGGCGAG
TTCACCGATGCGCCGGCCAGCTGGCAGCGCTACCTGGATGCCGGCGTGCTGATCCGCGACGTCGGCATCCCCGGCTACCT
GCGGGCCACCACCGGCCTGGCCGAGGAGAACGACGCCTTCCTGCGGGCCAGCGCCCAACTCGCCGCCACCGAGCTGGCCC
CCGTCAACGTAGGAGCGATCGCAAACGCAGCCGAGCCGCGCGCAGCGGGTCGCGACCGTGTGTTAGGAGCCCCATGA

Upstream 100 bases:

>100_bases
CCGAGGCGGCGCTGAAAGACGTGTCCGGGCACGTGATCACCCTGGCGCAGGCCGAAGACCTGCCGGCGCACGGCGAGGCG
ATACGGCGGAGGTTCGAGCG

Downstream 100 bases:

>100_bases
CCGCCGTGCAAGCTGCCCGTCGCGCGCGAATCGAGCGCCGCACCAAGGAATCCGACATCGTCATCGAACTCGACTTGGAC
GGCACCGGCCGGGTCGACGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTGQRATPQPTLDDLPLRDDLRGKSPYGAPQLAVPVRLNTNENPHPPSRALVDDVVRSVARAAADLHRYPDRDAVQLRSD
LARYLTAQTGVQLGVENLWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTRTEWLQAARADDFSLDVDAAV
AAVTERTPDVVFVASPNNPSGQSVSLSGLRRLLDAAPGIVIVDEAYGEFSSQPSAVQLVGEYPTKLVVTRTMSKAFAFAG
GRLGYLIATPAVIEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVSTALTGMGFRVIPSDANFVLFGE
FTDAPASWQRYLDAGVLIRDVGIPGYLRATTGLAEENDAFLRASAQLAATELAPVNVGAIANAAEPRAAGRDRVLGAP

Sequences:

>Translated_398_residues
MTGQRATPQPTLDDLPLRDDLRGKSPYGAPQLAVPVRLNTNENPHPPSRALVDDVVRSVARAAADLHRYPDRDAVQLRSD
LARYLTAQTGVQLGVENLWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTRTEWLQAARADDFSLDVDAAV
AAVTERTPDVVFVASPNNPSGQSVSLSGLRRLLDAAPGIVIVDEAYGEFSSQPSAVQLVGEYPTKLVVTRTMSKAFAFAG
GRLGYLIATPAVIEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVSTALTGMGFRVIPSDANFVLFGE
FTDAPASWQRYLDAGVLIRDVGIPGYLRATTGLAEENDAFLRASAQLAATELAPVNVGAIANAAEPRAAGRDRVLGAP
>Mature_397_residues
TGQRATPQPTLDDLPLRDDLRGKSPYGAPQLAVPVRLNTNENPHPPSRALVDDVVRSVARAAADLHRYPDRDAVQLRSDL
ARYLTAQTGVQLGVENLWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTRTEWLQAARADDFSLDVDAAVA
AVTERTPDVVFVASPNNPSGQSVSLSGLRRLLDAAPGIVIVDEAYGEFSSQPSAVQLVGEYPTKLVVTRTMSKAFAFAGG
RLGYLIATPAVIEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVSTALTGMGFRVIPSDANFVLFGEF
TDAPASWQRYLDAGVLIRDVGIPGYLRATTGLAEENDAFLRASAQLAATELAPVNVGAIANAAEPRAAGRDRVLGAP

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=375, Percent_Identity=32.2666666666667, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=28.169014084507, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42212; Mature: 42081

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQRATPQPTLDDLPLRDDLRGKSPYGAPQLAVPVRLNTNENPHPPSRALVDDVVRSVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
RAAADLHRYPDRDAVQLRSDLARYLTAQTGVQLGVENLWAANGSNEILQQLLQAFGGPGR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCC
SAIGFVPSYSMHPIISDGTRTEWLQAARADDFSLDVDAAVAAVTERTPDVVFVASPNNPS
CCEECCCCCCCCCEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GQSVSLSGLRRLLDAAPGIVIVDEAYGEFSSQPSAVQLVGEYPTKLVVTRTMSKAFAFAG
CCEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHCC
GRLGYLIATPAVIEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVSTA
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGMGFRVIPSDANFVLFGEFTDAPASWQRYLDAGVLIRDVGIPGYLRATTGLAEENDAF
HHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHH
LRASAQLAATELAPVNVGAIANAAEPRAAGRDRVLGAP
HHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TGQRATPQPTLDDLPLRDDLRGKSPYGAPQLAVPVRLNTNENPHPPSRALVDDVVRSVA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
RAAADLHRYPDRDAVQLRSDLARYLTAQTGVQLGVENLWAANGSNEILQQLLQAFGGPGR
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHHHCCCCC
SAIGFVPSYSMHPIISDGTRTEWLQAARADDFSLDVDAAVAAVTERTPDVVFVASPNNPS
CCEECCCCCCCCCEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCC
GQSVSLSGLRRLLDAAPGIVIVDEAYGEFSSQPSAVQLVGEYPTKLVVTRTMSKAFAFAG
CCEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHHHCC
GRLGYLIATPAVIEAMLLVRLPYHLSSVTQAAARAALRHADDTLGSVAALIAERERVSTA
CCEEEEEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGMGFRVIPSDANFVLFGEFTDAPASWQRYLDAGVLIRDVGIPGYLRATTGLAEENDAF
HHCCCEEEECCCCCEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCCCHH
LRASAQLAATELAPVNVGAIANAAEPRAAGRDRVLGAP
HHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA