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The map label for this gene is hisD

Identifier: 41407391

GI number: 41407391

Start: 1382135

End: 1383577

Strand: Direct

Name: hisD

Synonym: MAP1293

Alternate gene names: 41407391

Gene position: 1382135-1383577 (Clockwise)

Preceding gene: 41407389

Following gene: 41407392

Centisome position: 28.62

GC content: 74.22

Gene sequence:

>1443_bases
CTGTACCGGCCGGATATCGACTTGAGTTCCTCTGGGACAATGGACACCGTGAGTCCCACCCCGGCGTCACCGATGGCCGG
CATCGACCTGCGGGGCGCCGAGCTGACCGCTGCCCGATTGCGGTCGGCGCTGCCGCGCGGCGGCGCCGACGTGGAGACGG
TGCTGCCCAAGGTGCGACCCATCGTGCAGGCGGTGGCCGAGCGCGGCGCCGACGCCGCGCTGGAGTTCGGCGCCTCCTTC
GACGGTGTCCGCCCGGCGGCGGTCCGGGTGCCGGAGGCGGCGCTGGACAAGGCCCTGGCCGACCTGGACGCGGCCGTCGC
AGACGCCCTGCGGGTGATGATCGACCGCGCCCGCGCCGTGCACGCCGACCAGCGCCGCACCGACGTCACCACCACGCTGG
GACCGGGCGCGACGGTGACCGAGCGCTGGGTGCCGGTCGAGCGGGTGGGCCTGTACGTGCCCGGCGGCAACGCCGTCTAC
CCGTCCAGCGTGGTGATGAACGTGGTGCCCGCCCAGGCCGCCGGCGTCGCGTCGCTGGTGGTGGCCAGCCCGCCGCAGGC
CCAGTTCGACGGGCTGCCGCATCCGACCATCCTGGCCGCGGCCCGGCTGCTGGGCGTCGACGAGGTGTGGGCGGTCGGCG
GCGCGCAGGCGGTGGCGCTGCTGGCCTACGGCGGGACCGATACCGGGGCCGAATGGCCCGGCTTCTCCTCGGATCGCGCA
CGATCCGCATCGTCGCCGGGGGCAGACGCCGAGCTGGTGCCGGTCGACATGATCACCGGGCCGGGCAACATCTACGTCAC
CGCCGCCAAGCGGCTGTGCCGGTCGCGGGTCGGCATCGACGCCGAGGCCGGGCCGACCGAGATCGCGATCCTGGCCGACC
ACACCGCCGACCCCGCGCACGTGGCCGCCGACCTGATCAGCCAGGCCGAGCACGACGAGATGGCCGGCAGCGTGCTGGTC
ACCCCCAGCGAGGACCTGGCCGCGGCCACCGACGCGGAACTGGCCGCCCAGCTGCCGACCACCGTGCACCGCGAGCGGGT
GACCGCCGCGCTGGGCGGACGCCAGTCGGCGATCATCCTGGTCGACGACCTGGACGCCGGGATCACGGTCGTCAACGCCT
ACGCCGCCGAGCACCTGGAGATCCAGACCGCCGACGCGGCGGCCGTGGCCGGCCGGATCCGCGCGGCCGGAGCCGTTTTC
GTCGGCCCGTACTCGCCGGTCAGCCTGGGCGACTACTGCGCCGGCTCCAATCACGTCCTGCCCACCGCGGGCAGCGCCCG
GCATTCCAGCGGCCTGTCGGTGCAGACCTTCTTGCGCGGCATCCACGTCGTCGACTACACCGAGGCGGCGCTGAAAGACG
TGTCCGGGCACGTGATCACCCTGGCGCAGGCCGAAGACCTGCCGGCGCACGGCGAGGCGATACGGCGGAGGTTCGAGCGG
TGA

Upstream 100 bases:

>100_bases
CTCCGTGGGGTCGGCTCGTGCTGTCGGCGCGGGGTAGGGCCTCGATCCCGGCCTCGATCCCGGCCTCGATACGGGCACTG
TACCGGCCGCGATCCAGGCG

Downstream 100 bases:

>100_bases
CCGGCCAGCGGGCCACCCCCCAACCCACGCTGGACGACCTGCCGCTGCGCGACGACCTGCGCGGCAAATCGCCTTACGGG
GCACCGCAATTGGCGGTCCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQAVAERGADAALEFGASF
DGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVY
PSSVVMNVVPAQAAGVASLVVASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRA
RSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLISQAEHDEMAGSVLV
TPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVF
VGPYSPVSLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER

Sequences:

>Translated_480_residues
MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQAVAERGADAALEFGASF
DGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVY
PSSVVMNVVPAQAAGVASLVVASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRA
RSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLISQAEHDEMAGSVLV
TPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVF
VGPYSPVSLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER
>Mature_480_residues
MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRPIVQAVAERGADAALEFGASF
DGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAVHADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVY
PSSVVMNVVPAQAAGVASLVVASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRA
RSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAHVAADLISQAEHDEMAGSVLV
TPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIILVDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVF
VGPYSPVSLGDYCAGSNHVLPTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=447, Percent_Identity=35.3467561521253, Blast_Score=220, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319819, Length=452, Percent_Identity=34.070796460177, Blast_Score=228, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_MYCPA (P60860)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960227.1
- ProteinModelPortal:   P60860
- SMR:   P60860
- EnsemblBacteria:   EBMYCT00000039273
- GeneID:   2717805
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1293
- NMPDR:   fig|262316.1.peg.1293
- GeneTree:   EBGT00050000017368
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 49373; Mature: 49373

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 377-377 ACT_SITE 378-378 BINDING 152-152 BINDING 216-216 BINDING 263-263 BINDING 286-286 BINDING 308-308 BINDING 311-311 BINDING 378-378 BINDING 411-411 BINDING 465-465 BINDING 470-470

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
IVQAVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAV
HHHHHHHCCCCHHHHCCCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVASLV
HCCCCCCCCEEECCCCCCHHHCCCCHHHEEEEECCCCCCCCCHHHHHCCCCHHCCCEEEE
VASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRA
EECCCCHHHCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHH
RSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAH
CCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHH
VAADLISQAEHDEMAGSVLVTPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIIL
HHHHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
VDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPVSLGDYCAGSNHVL
EECCCCCEEEEEHHHHHHEEEECCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCEE
PTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER
CCCCCCCCCCCCCHHHHHHHCEEEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MYRPDIDLSSSGTMDTVSPTPASPMAGIDLRGAELTAARLRSALPRGGADVETVLPKVRP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHH
IVQAVAERGADAALEFGASFDGVRPAAVRVPEAALDKALADLDAAVADALRVMIDRARAV
HHHHHHHCCCCHHHHCCCCCCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HADQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVASLV
HCCCCCCCCEEECCCCCCHHHCCCCHHHEEEEECCCCCCCCCHHHHHCCCCHHCCCEEEE
VASPPQAQFDGLPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTGAEWPGFSSDRA
EECCCCHHHCCCCCHHHHHHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHH
RSASSPGADAELVPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPAH
CCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHH
VAADLISQAEHDEMAGSVLVTPSEDLAAATDAELAAQLPTTVHRERVTAALGGRQSAIIL
HHHHHHHHHHHHHHCCCEEECCCHHHHHHCCHHHHHHCCHHHHHHHHHHHHCCCCEEEEE
VDDLDAGITVVNAYAAEHLEIQTADAAAVAGRIRAAGAVFVGPYSPVSLGDYCAGSNHVL
EECCCCCEEEEEHHHHHHEEEECCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCEE
PTAGSARHSSGLSVQTFLRGIHVVDYTEAALKDVSGHVITLAQAEDLPAHGEAIRRRFER
CCCCCCCCCCCCCHHHHHHHCEEEEHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA