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The map label for this gene is nadC

Identifier: 41407389

GI number: 41407389

Start: 1380641

End: 1381495

Strand: Direct

Name: nadC

Synonym: MAP1291

Alternate gene names: 41407389

Gene position: 1380641-1381495 (Clockwise)

Preceding gene: 41407388

Following gene: 41407391

Centisome position: 28.59

GC content: 72.63

Gene sequence:

>855_bases
ATGATCTCGGACTGCGAGCTCACCGCGGCGCGCGAGATCATCCGGCGCGGCCTGGTCGAGGACCTGCGCTACGGGCCCGA
CGTCACCACGTTGGCGACGGTGCCCGCCGAGGCGGTGGCCACCGCGTCGATGGTGCCCCGGCAGCCCGGCGTGATCGCCG
GGGTGGACATCGCGCTGCTGGTGCTGGACGAGGTGCTCGGCGCCCGCGGCTATCAGGTGCTCGACCGCGTCGAGGACGGC
GCCCACCTGCAGCCGGGCCAGTCGCTGCTGACCGTGCGGGCCGAAACCCGCGGTCTGCTGACCGCGGAGCGCACCATGCT
GAACCTGATCTGCCACCTGTCCGGGATCGCCACCACGACGGCGCACTGGGTGGCCGCCGTGCAAGGCACCAAGGCCCAGG
TGCGCGACACCCGCAAGACGCTGCCCGGCCTGCGGGCGTTGCAGAAATACGCGGTCCGGGTCGGCGGCGGCGTCAACCAC
CGGCTCGGTCTCGGCGACGCCGCGCTGATCAAGGACAACCACGTGGTGGCCGCCGGGTCGGTGGTCGACGCGCTGCGGGC
GGTGCGGGACGCGGCGCCGGAGCTGCCCTGCGAGGTGGAGGTCGACTCGCTCGAGCAGCTCGACGAGGTGCTGCCGGAAA
AGCCCGAACTGGTGCTGCTGGACAACTTCCCGGTGTGGCAGACGCAGATGGCCGTGCAGCGGCGCGACGCGCGCGCGCCC
GCGGTCCTGCTCGAGTCCTCCGGCGGCCTCAGCCTGGAGAACGCCGCCGACTACGCCGCGACCGGGGTGGATTACCTGGC
CGTCGGCGCGCTGACCCATTCGGTGCGGGTGCTCGACATCGGCCTGGACATGTAG

Upstream 100 bases:

>100_bases
ATCCGCAGGCCGCGCCCGAGCAGGCGCGCAGCAACCTGCTGCGACTGGCCGACGACCAGAACTCGGTGCTGGTGCAGGCG
CTGGCGGCGGTGGTGTGACG

Downstream 100 bases:

>100_bases
CGGGTTGGGCATCCTGGGCGCCTTGGGCGCCCGAGTGGGCATCCTGGGCGTTCGGTGTAGCACCAGGTAGCGACTTCTCG
GCGTGTCGGCGCCACCAGTG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPAEAVATASMVPRQPGVIAGVDIALLVLDEVLGARGYQVLDRVEDG
AHLQPGQSLLTVRAETRGLLTAERTMLNLICHLSGIATTTAHWVAAVQGTKAQVRDTRKTLPGLRALQKYAVRVGGGVNH
RLGLGDAALIKDNHVVAAGSVVDALRAVRDAAPELPCEVEVDSLEQLDEVLPEKPELVLLDNFPVWQTQMAVQRRDARAP
AVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLDM

Sequences:

>Translated_284_residues
MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPAEAVATASMVPRQPGVIAGVDIALLVLDEVLGARGYQVLDRVEDG
AHLQPGQSLLTVRAETRGLLTAERTMLNLICHLSGIATTTAHWVAAVQGTKAQVRDTRKTLPGLRALQKYAVRVGGGVNH
RLGLGDAALIKDNHVVAAGSVVDALRAVRDAAPELPCEVEVDSLEQLDEVLPEKPELVLLDNFPVWQTQMAVQRRDARAP
AVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLDM
>Mature_284_residues
MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPAEAVATASMVPRQPGVIAGVDIALLVLDEVLGARGYQVLDRVEDG
AHLQPGQSLLTVRAETRGLLTAERTMLNLICHLSGIATTTAHWVAAVQGTKAQVRDTRKTLPGLRALQKYAVRVGGGVNH
RLGLGDAALIKDNHVVAAGSVVDALRAVRDAAPELPCEVEVDSLEQLDEVLPEKPELVLLDNFPVWQTQMAVQRRDARAP
AVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLDM

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=262, Percent_Identity=35.4961832061069, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786299, Length=253, Percent_Identity=42.2924901185771, Blast_Score=177, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321162, Length=288, Percent_Identity=29.5138888888889, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30211; Mature: 30211

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPAEAVATASMVPRQPGVIAGVDIALL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCCCEEEHHHHHHH
VLDEVLGARGYQVLDRVEDGAHLQPGQSLLTVRAETRGLLTAERTMLNLICHLSGIATTT
HHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
AHWVAAVQGTKAQVRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVVAAGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEHHH
VVDALRAVRDAAPELPCEVEVDSLEQLDEVLPEKPELVLLDNFPVWQTQMAVQRRDARAP
HHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
AVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLDM
EEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHCEEEEEECCCC
>Mature Secondary Structure
MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPAEAVATASMVPRQPGVIAGVDIALL
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCCCCEEEHHHHHHH
VLDEVLGARGYQVLDRVEDGAHLQPGQSLLTVRAETRGLLTAERTMLNLICHLSGIATTT
HHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHH
AHWVAAVQGTKAQVRDTRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVVAAGS
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEHHH
VVDALRAVRDAAPELPCEVEVDSLEQLDEVLPEKPELVLLDNFPVWQTQMAVQRRDARAP
HHHHHHHHHHCCCCCCCEECHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCC
AVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLDM
EEEEECCCCCCCCCCCHHHHCCHHHHHHHHHHHCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]