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The map label for this gene is nadB

Identifier: 41407388

GI number: 41407388

Start: 1379046

End: 1380638

Strand: Direct

Name: nadB

Synonym: MAP1290

Alternate gene names: 41407388

Gene position: 1379046-1380638 (Clockwise)

Preceding gene: 41407387

Following gene: 41407389

Centisome position: 28.55

GC content: 75.71

Gene sequence:

>1593_bases
ATGATCGCCCGTCCCCAGTGGACACACAGCGCCGACGTCGTCGTGATCGGCACCGGCGTCGCCGGATTGGCCGCCGCGCT
GGCCGCCCACCGCGCCGGCCGCAGCGTCGTCGTGCTGAGCAAGGCCGACCAGGCGCGCGGGGCCACCGCCACCCACTACG
CGCAGGGCGGCATCGCGGTGGTGTTGCCGCACAACGACGATTCGGTCGAGGCCCATGTCGCCGACACCGTCGTCGCGGGC
GCGGGCCTGTGCGACCCGCAGGCGGTCTACTCGATCGTGGCCGACGGGTACGCGGCGGTCTCCGAATTGGTCGGTGACGG
AGCGCGATTCGACGAATCGGCCCCCGGCCAGTGGGCGCTGACCCGCGAGGGCGGGCACTCCCGGCGCCGCATCGTGCACG
CCGGCGGCGACGCCACCGGCGCCGAGGTGCAGCGCGCGCTCGACCACGCCGCACGGATGCTGGACATCCGCACCGCGCAC
GTGGCGCTGCGGGTGCTGCACGACGGCTCCATGGGCGACGAAGCCGTCACCGGCGTGCTGGTCGGCAACCCGCACGGCTG
CGGGATCATCAGCGCGCCGTCGGTGATCCTGGCCTCGGGCGGTCTCGGGCACCTCTACGGCGCGACCACCAACCCGGAGG
GCTCCACCGGCGACGGCATCGCGCTGGGCCTGTGGGCCGGTGTCGCGGTCAGCGACCTGGAGTTCATCCAGTTCCATCCC
ACCATGCTCTTCGCCCCCGGCGCCGGCGGCGGTCGGCGCCCGCTGGTCACCGAGGCCATCCGCGGCGAGGGAGCGAAACT
GATTGATTCCCAAGGCGATTCGGTGACCGCCGGGGTGCACCCGATGGGCGACCTGGCGCCGCGCGACGTGGTCGCCGCCG
CCATCGACGCGCGGCTGAAAGCCACCGGCGACGCCTGCGTCTACCTGGACGCGCGGCACATCTTCGACTTCGCCGACCGG
TTCCCGACCGTGACGGCGGCCTGCCGGGCCGCCGGCATCGACCCGGTGCGCCAACCCATCCCCGTGGTGCCCGGGGCGCA
CTACAGCTGCGGCGGCGTCGTCACCGACGTGTACGGCCGGACCGAGCTGCCCGGCCTGTTCGCCGCCGGCGAGGTGGCCC
GCACCGGGCTGCACGGCGCCAACCGGCTGGCGTCCAACAGCCTGCTGGAAGGTCTGGTGGTCGGGGGCCGGGCCGGCAGG
GCGGCGGCCGCGCATGCGGCGGAGGCCGGCCGCCCCCGCGCGCTGGCGCCCGAGCCCGTTGCGCACACCGCGCCGCCGCG
CGCGGAGTTGCAGGCCGCGATGAGCCGCGACGCGTCGGTGGTGCGCGACCCGGCCGGGCTGACCCGGTTGTCGGCCACCC
TGTCGCAGGCGCCGGCCCGCAGCATCGGCGGCCGCCGCGACTTCGAGGACGTGGCGTTGGCCGTCGCCGCCCGCGCGGTC
GCGGCCGCGGCCCTGGCCCGCACCGAGAGCCGCGGCTGCCACCACCGCGAGGAGCATCCGCAGGCCGCGCCCGAGCAGGC
GCGCAGCAACCTGCTGCGACTGGCCGACGACCAGAACTCGGTGCTGGTGCAGGCGCTGGCGGCGGTGGTGTGA

Upstream 100 bases:

>100_bases
TCGAGGGCGCCGACGAGGTGCACGTCGATCCCGGCATCGCGGCTGCCGGCCGGCGCAGCGTGCAGCGCATGATCGAGATC
GGCCAGCCGGGCGGTGGCGA

Downstream 100 bases:

>100_bases
CGATGATCTCGGACTGCGAGCTCACCGCGGCGCGCGAGATCATCCGGCGCGGCCTGGTCGAGGACCTGCGCTACGGGCCC
GACGTCACCACGTTGGCGAC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MIARPQWTHSADVVVIGTGVAGLAAALAAHRAGRSVVVLSKADQARGATATHYAQGGIAVVLPHNDDSVEAHVADTVVAG
AGLCDPQAVYSIVADGYAAVSELVGDGARFDESAPGQWALTREGGHSRRRIVHAGGDATGAEVQRALDHAARMLDIRTAH
VALRVLHDGSMGDEAVTGVLVGNPHGCGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFIQFHP
TMLFAPGAGGGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDLAPRDVVAAAIDARLKATGDACVYLDARHIFDFADR
FPTVTAACRAAGIDPVRQPIPVVPGAHYSCGGVVTDVYGRTELPGLFAAGEVARTGLHGANRLASNSLLEGLVVGGRAGR
AAAAHAAEAGRPRALAPEPVAHTAPPRAELQAAMSRDASVVRDPAGLTRLSATLSQAPARSIGGRRDFEDVALAVAARAV
AAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALAAVV

Sequences:

>Translated_530_residues
MIARPQWTHSADVVVIGTGVAGLAAALAAHRAGRSVVVLSKADQARGATATHYAQGGIAVVLPHNDDSVEAHVADTVVAG
AGLCDPQAVYSIVADGYAAVSELVGDGARFDESAPGQWALTREGGHSRRRIVHAGGDATGAEVQRALDHAARMLDIRTAH
VALRVLHDGSMGDEAVTGVLVGNPHGCGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFIQFHP
TMLFAPGAGGGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDLAPRDVVAAAIDARLKATGDACVYLDARHIFDFADR
FPTVTAACRAAGIDPVRQPIPVVPGAHYSCGGVVTDVYGRTELPGLFAAGEVARTGLHGANRLASNSLLEGLVVGGRAGR
AAAAHAAEAGRPRALAPEPVAHTAPPRAELQAAMSRDASVVRDPAGLTRLSATLSQAPARSIGGRRDFEDVALAVAARAV
AAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALAAVV
>Mature_530_residues
MIARPQWTHSADVVVIGTGVAGLAAALAAHRAGRSVVVLSKADQARGATATHYAQGGIAVVLPHNDDSVEAHVADTVVAG
AGLCDPQAVYSIVADGYAAVSELVGDGARFDESAPGQWALTREGGHSRRRIVHAGGDATGAEVQRALDHAARMLDIRTAH
VALRVLHDGSMGDEAVTGVLVGNPHGCGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFIQFHP
TMLFAPGAGGGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDLAPRDVVAAAIDARLKATGDACVYLDARHIFDFADR
FPTVTAACRAAGIDPVRQPIPVVPGAHYSCGGVVTDVYGRTELPGLFAAGEVARTGLHGANRLASNSLLEGLVVGGRAGR
AAAAHAAEAGRPRALAPEPVAHTAPPRAELQAAMSRDASVVRDPAGLTRLSATLSQAPARSIGGRRDFEDVALAVAARAV
AAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALAAVV

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=535, Percent_Identity=31.214953271028, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788928, Length=523, Percent_Identity=39.5793499043977, Blast_Score=308, Evalue=8e-85,
Organism=Escherichia coli, GI1790597, Length=539, Percent_Identity=31.7254174397032, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1786942, Length=574, Percent_Identity=31.8815331010453, Blast_Score=175, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17505833, Length=553, Percent_Identity=29.1139240506329, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=542, Percent_Identity=29.3357933579336, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=572, Percent_Identity=31.2937062937063, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6322416, Length=575, Percent_Identity=30.2608695652174, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320788, Length=475, Percent_Identity=27.3684210526316, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137288, Length=566, Percent_Identity=31.2720848056537, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24655642, Length=566, Percent_Identity=31.2720848056537, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24655647, Length=566, Percent_Identity=31.2720848056537, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24663005, Length=562, Percent_Identity=29.3594306049822, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 54029; Mature: 54029

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARPQWTHSADVVVIGTGVAGLAAALAAHRAGRSVVVLSKADQARGATATHYAQGGIAV
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCEEE
VLPHNDDSVEAHVADTVVAGAGLCDPQAVYSIVADGYAAVSELVGDGARFDESAPGQWAL
EEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
TREGGHSRRRIVHAGGDATGAEVQRALDHAARMLDIRTAHVALRVLHDGSMGDEAVTGVL
ECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEE
VGNPHGCGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFIQFHP
EECCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHCCHHHCCCEEEECC
TMLFAPGAGGGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDLAPRDVVAAAIDARLK
EEEEECCCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHE
ATGDACVYLDARHIFDFADRFPTVTAACRAAGIDPVRQPIPVVPGAHYSCGGVVTDVYGR
ECCCEEEEEEHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEECCCC
TELPGLFAAGEVARTGLHGANRLASNSLLEGLVVGGRAGRAAAAHAAEAGRPRALAPEPV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCC
AHTAPPRAELQAAMSRDASVVRDPAGLTRLSATLSQAPARSIGGRRDFEDVALAVAARAV
CCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHH
AAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALAAVV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MIARPQWTHSADVVVIGTGVAGLAAALAAHRAGRSVVVLSKADQARGATATHYAQGGIAV
CCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCCCEEE
VLPHNDDSVEAHVADTVVAGAGLCDPQAVYSIVADGYAAVSELVGDGARFDESAPGQWAL
EEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
TREGGHSRRRIVHAGGDATGAEVQRALDHAARMLDIRTAHVALRVLHDGSMGDEAVTGVL
ECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEE
VGNPHGCGIISAPSVILASGGLGHLYGATTNPEGSTGDGIALGLWAGVAVSDLEFIQFHP
EECCCCCCEECCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHCCHHHCCCEEEECC
TMLFAPGAGGGRRPLVTEAIRGEGAKLIDSQGDSVTAGVHPMGDLAPRDVVAAAIDARLK
EEEEECCCCCCCCCHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHE
ATGDACVYLDARHIFDFADRFPTVTAACRAAGIDPVRQPIPVVPGAHYSCGGVVTDVYGR
ECCCEEEEEEHHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCEECCCC
TELPGLFAAGEVARTGLHGANRLASNSLLEGLVVGGRAGRAAAAHAAEAGRPRALAPEPV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCC
AHTAPPRAELQAAMSRDASVVRDPAGLTRLSATLSQAPARSIGGRRDFEDVALAVAARAV
CCCCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHH
AAAALARTESRGCHHREEHPQAAPEQARSNLLRLADDQNSVLVQALAAVV
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]