Click here to switch to the map view.

The map label for this gene is apt

Identifier: 41407144

GI number: 41407144

Start: 1095244

End: 1095786

Strand: Direct

Name: apt

Synonym: MAP1046

Alternate gene names: 41407144

Gene position: 1095244-1095786 (Clockwise)

Preceding gene: 41407143

Following gene: 41407145

Centisome position: 22.68

GC content: 74.03

Gene sequence:

>543_bases
ATGACGGACGCCGGCGAAGCGACGCCGGTCGCGGAGCTCATCGCGTCGCTGACCCGGCAGGTGCCCGATTTCCCCAAGCC
CGGCATCCAGTTCAAGGACCTCACCCCGCTGTTCGCCGAAGCGACGGCGATGACGGCCGTCACCGGCGCGCTGGCCCGGC
ACGCGTCCGGTGCCGACCTGGTGGCCGGCATCGACTCGCGCGGGTTCCTGGTCGCGGCGGCCGTGGCCGACCGGCTGCAC
ACCGGGGTGCTGGCCATCCGCAAGGGCGGCAAACTGCCGCCGCCGGTGCACGCCGAGCGCTACGACCTGGAATACGGCAG
CGCCACCCTGGAGATCCCCGCCGACGGCATCGACCTGCGTGGGCGGCGCATCGTGATCATCGACGACGTGCTGGCCACCG
GCGGTACCCTGGCCGCGGCGGCCCGACTGCTGCGGCGCACCGGCGCCACCGTGACCGCGGCGGCGGTGGTGTTCGAACTC
GGTGCGCTGGGCGGGCGGGCGGCGCTGGCGCCGTTGCCGGTGCACAGCCTGACTTGCCAGTAG

Upstream 100 bases:

>100_bases
CTGCTGATCTCCAAGAAGATGTACGCGGTGAGCAAGAACCCCACCCGGTGGGGCGCGGGGTGGAACATGGACCGATGGGC
CCTGGTGCAGTGAGGTCGGC

Downstream 100 bases:

>100_bases
CCCCGCGACATCGGAGATATCCTCGAATTCGGAGGTGAGCATCGTGGCGGAGGAAAACAGCGCGGCGCAAGCGCTTGACG
CGCCGGCGGAGTCGCCGCCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTDAGEATPVAELIASLTRQVPDFPKPGIQFKDLTPLFAEATAMTAVTGALARHASGADLVAGIDSRGFLVAAAVADRLH
TGVLAIRKGGKLPPPVHAERYDLEYGSATLEIPADGIDLRGRRIVIIDDVLATGGTLAAAARLLRRTGATVTAAAVVFEL
GALGGRAALAPLPVHSLTCQ

Sequences:

>Translated_180_residues
MTDAGEATPVAELIASLTRQVPDFPKPGIQFKDLTPLFAEATAMTAVTGALARHASGADLVAGIDSRGFLVAAAVADRLH
TGVLAIRKGGKLPPPVHAERYDLEYGSATLEIPADGIDLRGRRIVIIDDVLATGGTLAAAARLLRRTGATVTAAAVVFEL
GALGGRAALAPLPVHSLTCQ
>Mature_179_residues
TDAGEATPVAELIASLTRQVPDFPKPGIQFKDLTPLFAEATAMTAVTGALARHASGADLVAGIDSRGFLVAAAVADRLHT
GVLAIRKGGKLPPPVHAERYDLEYGSATLEIPADGIDLRGRRIVIIDDVLATGGTLAAAARLLRRTGATVTAAAVVFELG
ALGGRAALAPLPVHSLTCQ

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=44.4444444444444, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=43.75, Blast_Score=109, Evalue=1e-24,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=38.6363636363636, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17509087, Length=168, Percent_Identity=40.4761904761905, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323619, Length=165, Percent_Identity=36.3636363636364, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320649, Length=182, Percent_Identity=31.8681318681319, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=38.8235294117647, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18452; Mature: 18320

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAGEATPVAELIASLTRQVPDFPKPGIQFKDLTPLFAEATAMTAVTGALARHASGADL
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VAGIDSRGFLVAAAVADRLHTGVLAIRKGGKLPPPVHAERYDLEYGSATLEIPADGIDLR
EEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCEEEEECCCCCCCC
GRRIVIIDDVLATGGTLAAAARLLRRTGATVTAAAVVFELGALGGRAALAPLPVHSLTCQ
CCEEEEEECCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDAGEATPVAELIASLTRQVPDFPKPGIQFKDLTPLFAEATAMTAVTGALARHASGADL
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCE
VAGIDSRGFLVAAAVADRLHTGVLAIRKGGKLPPPVHAERYDLEYGSATLEIPADGIDLR
EEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEECCCCCEEEEECCCCCCCC
GRRIVIIDDVLATGGTLAAAARLLRRTGATVTAAAVVFELGALGGRAALAPLPVHSLTCQ
CCEEEEEECCHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA