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The map label for this gene is relA

Identifier: 41407145

GI number: 41407145

Start: 1095830

End: 1098196

Strand: Direct

Name: relA

Synonym: MAP1047

Alternate gene names: 41407145

Gene position: 1095830-1098196 (Clockwise)

Preceding gene: 41407144

Following gene: 41407149

Centisome position: 22.69

GC content: 68.86

Gene sequence:

>2367_bases
GTGGCGGAGGAAAACAGCGCGGCGCAAGCGCTTGACGCGCCGGCGGAGTCGCCGCCCAACCCGGTGATCGAGACTCCCGA
GCCGCCGACCGAATCGCTCAAGACGTCCAGCAGCGCGTCGCGCCGGGTCCGGGCCCGGCTGGCCCGGCGGATGACCGCCC
AGCGCAGCACGCTCAACCCGGTGCTGGAGCCGCTGGTGGCGATGCACCGCGAGATCTACCCCAAGGCCAACGTGCAGCTG
CTGCAGCGCGCATTCGAGGTCGCCGACCAGCGGCACGCCAGCCAGTTGCGCCACTCCGGCGACCCCTACATCACCCATCC
GCTGGCCGTCGCCACCATCCTGGCCGAATTGGGCATGGACACCACCACTTTGGTGGCCGCGCTGTTGCACGACACCGTCG
AGGACACCGGCTACACCCTGGCCCAGCTGTCCGAGGAATTCGGCGAAGAGGTCGGTCATCTGGTCGACGGGGTGACCAAG
CTGGACCGGGTGGTGCTGGGCAGCGCCGCCGAGGGCGAGACCATCCGCAAGATGATCACCGCGATGGCCCGCGACCCGCG
GGTGCTGGTGATCAAGGTCGCCGACCGGCTGCACAACATGCGCACCATGCGGTTCCTGCCGCCGGAGAAGCAGGCCCGCA
AGGCCCGCGAGACGCTGGAAGTCATTGCGCCCCTCGCCCATCGGCTGGGCATGGCCAGCGTCAAGTGGGAGTTGGAGGAC
CTGTCGTTCGCCATCCTGCATCCCAAGAAGTACGACGAGATCGTCCGGCTGGTCGCCGGCCGGGCCCCGTCGCGGGACAC
CTACCTGGCCAAGGTGCGGGCCGAGATCATCAACACGCTGAACGCGTCGAAGATCAAGGCGACGGTGGAGGGCCGGCCCA
AGCACTACTGGTCGATCTACCAGAAGATGATCGTCAAGGGCCGCGACTTCGACGACATCCACGACCTGGTCGGCATCCGC
ATCCTGTGCGACGAGATCCGGGACTGCTATGCCGCTGTGGGCGTGGTGCATTCGCTGTGGCAGCCGATGGCCGGGCGGTT
CAAGGACTACATCGCCCAGCCGCGCTACGGCGTCTACCAGTCGCTGCACACCACCGTCGTCGGGCCGGAGGGCAAGCCGC
TGGAGGTGCAGATCCGCACCCGCGACATGCACCGCACCGCCGAGTACGGCATCGCCGCGCACTGGCGCTACAAGGAAGCC
AAGGGCCGCAACGGCGTTCCGCACCCGCACGCCGCCGCCGAGATCGACGACATGGCCTGGATGCGCCAGCTGCTCGACTG
GCAGCGGGAAGCCGCCGACCCGGGCGAATTCCTCGAGTCGCTGCGCTATGACCTTGCGGTACAAGAGATCTTCGTGTTCA
CCCCCAAGGGCGACGTGATCACCCTGCCCACCGGGTCGACGCCGATCGACTTCGCCTATGCCGTGCACACCGAGGTCGGG
CACCGCTGCATCGGCGCCCGGGTCAACGGCCGGCTGGTGGCGCTGGAACGCAAGCTGGAAAACGGGGAAGTCGTCGAGGT
TTTCACCTCCAAGGCGGCCAACGCGGGCCCGTCGCGGGACTGGCAGCAGTTCGTGGTGTCGCCGCGGGCCAAGGCCAAGA
TCCGGCAGTGGTTCGCCAAGGAGCGGCGCGAGGAGGCCCTGGAGGCCGGCAAGGACGCGATGGCCCGCGAGGTGCGCCGC
GGCGGACTTCCGTTGCAGCGCTTGGTCAATGCCGAATCCATGAGCGCGGTGGCCCGCGAACTGCACTACGCCGACGTGTC
GGCCCTCTACACCGCGATCGGTGAGGGGCATGTGTCGGCCCGGCACGTGGTGCAGCGGCTGCTGGCCGAGCTCGGCGGCA
TCGACCAGACCGAGGAGGACCTCGCCGAGCGGTCCACCCCGACCACCATGCTGCGCCGCCCGCGCAGCAGCGACGACGTC
GGCGTGTCGGTGCCCGGCGCCCCGGGCGTGCTGACCAAGCTGGCCAAATGCTGCACGCCGGTGCCTGGGGACCAGATCAT
GGGATTCGTCACCCGCGGCGGCGGGGTGAGCGTGCACCGCACCGACTGCACCAACGCCGCCTCGCTGCAGCAGCAGTCCG
AGCGCATCATCGAGGTGCACTGGGCGCCGTCGCCGTCGTCGGTGTTCCTGGTGGCCATTCAGGTCGAGGCGCTCGACCGG
CACCGGCTGTTGTCCGACGTCACCCGGGTGCTGGCCGACGAGAAGGTCAACATCCTGTCCGCGTCGGTCACCACCTCCGG
TGACCGGGTTGCCATCAGCCGCTTCACCTTTGAGATGGGCGACCCCAAGCACCTCGGCCACCTGCTCAACGTGGTGCGCA
ACGTCGAAGGCGTCTACGACGTCTACCGGGTGACCTCCGCCGCCTGA

Upstream 100 bases:

>100_bases
CTGGGCGGGCGGGCGGCGCTGGCGCCGTTGCCGGTGCACAGCCTGACTTGCCAGTAGCCCCGCGACATCGGAGATATCCT
CGAATTCGGAGGTGAGCATC

Downstream 100 bases:

>100_bases
GCCCTAGCTGTACTGACCTGAGAGGTTAGGTACGCGGCTGGCGGGTGGTTGGCCGCCAAGTGCGGTGTGGCCGCGGTGGT
GATTGTAGGTGTGCAGCCAG

Product: RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 788; Mature: 787

Protein sequence:

>788_residues
MAEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNPVLEPLVAMHREIYPKANVQL
LQRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTLAQLSEEFGEEVGHLVDGVTK
LDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELED
LSFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTLNASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIR
ILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEA
KGRNGVPHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVG
HRCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAKERREEALEAGKDAMAREVRR
GGLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSARHVVQRLLAELGGIDQTEEDLAERSTPTTMLRRPRSSDDV
GVSVPGAPGVLTKLAKCCTPVPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDR
HRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA

Sequences:

>Translated_788_residues
MAEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNPVLEPLVAMHREIYPKANVQL
LQRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTLAQLSEEFGEEVGHLVDGVTK
LDRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELED
LSFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTLNASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIR
ILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEA
KGRNGVPHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVG
HRCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAKERREEALEAGKDAMAREVRR
GGLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSARHVVQRLLAELGGIDQTEEDLAERSTPTTMLRRPRSSDDV
GVSVPGAPGVLTKLAKCCTPVPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDR
HRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA
>Mature_787_residues
AEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNPVLEPLVAMHREIYPKANVQLL
QRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTGYTLAQLSEEFGEEVGHLVDGVTKL
DRVVLGSAAEGETIRKMITAMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELEDL
SFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTLNASKIKATVEGRPKHYWSIYQKMIVKGRDFDDIHDLVGIRI
LCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQSLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAK
GRNGVPHPHAAAEIDDMAWMRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVGH
RCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAKERREEALEAGKDAMAREVRRG
GLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSARHVVQRLLAELGGIDQTEEDLAERSTPTTMLRRPRSSDDVG
VSVPGAPGVLTKLAKCCTPVPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDRH
RLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYDVYRVTSAA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=141, Percent_Identity=39.7163120567376, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790082, Length=730, Percent_Identity=39.1780821917808, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=37.9160636758321, Blast_Score=483, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 87359; Mature: 87228

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNP
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VLEPLVAMHREIYPKANVQLLQRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCC
TTTLVAALLHDTVEDTGYTLAQLSEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMIT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELED
HHCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHH
LSFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTLNASKIKATVEGRPKHYWSIY
CEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHH
QKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVPHPHAAAEIDDMAW
HHHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHHHH
MRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVG
HHHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHEEHHHHHC
HRCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAK
CHHCCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
ERREEALEAGKDAMAREVRRGGLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSA
HHHHHHHHHCHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RHVVQRLLAELGGIDQTEEDLAERSTPTTMLRRPRSSDDVGVSVPGAPGVLTKLAKCCTP
HHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCC
VPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDR
CCCHHHEEEEECCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCCCEEEEEEEEHHHHH
HRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYD
HHHHHHHHHHHHCCCHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
VYRVTSAA
HHHHHCCC
>Mature Secondary Structure 
AEENSAAQALDAPAESPPNPVIETPEPPTESLKTSSSASRRVRARLARRMTAQRSTLNP
CCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
VLEPLVAMHREIYPKANVQLLQRAFEVADQRHASQLRHSGDPYITHPLAVATILAELGMD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCC
TTTLVAALLHDTVEDTGYTLAQLSEEFGEEVGHLVDGVTKLDRVVLGSAAEGETIRKMIT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AMARDPRVLVIKVADRLHNMRTMRFLPPEKQARKARETLEVIAPLAHRLGMASVKWELED
HHCCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHH
LSFAILHPKKYDEIVRLVAGRAPSRDTYLAKVRAEIINTLNASKIKATVEGRPKHYWSIY
CEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHH
QKMIVKGRDFDDIHDLVGIRILCDEIRDCYAAVGVVHSLWQPMAGRFKDYIAQPRYGVYQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SLHTTVVGPEGKPLEVQIRTRDMHRTAEYGIAAHWRYKEAKGRNGVPHPHAAAEIDDMAW
HHHHEEECCCCCCEEEEEECCHHHHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHHHHH
MRQLLDWQREAADPGEFLESLRYDLAVQEIFVFTPKGDVITLPTGSTPIDFAYAVHTEVG
HHHHHHHHHHCCCHHHHHHHHHHHHEEEHEEEECCCCCEEEECCCCCCCCHHEEHHHHHC
HRCIGARVNGRLVALERKLENGEVVEVFTSKAANAGPSRDWQQFVVSPRAKAKIRQWFAK
CHHCCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
ERREEALEAGKDAMAREVRRGGLPLQRLVNAESMSAVARELHYADVSALYTAIGEGHVSA
HHHHHHHHHCHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RHVVQRLLAELGGIDQTEEDLAERSTPTTMLRRPRSSDDVGVSVPGAPGVLTKLAKCCTP
HHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCCEEECCCCCHHHHHHHHHCCC
VPGDQIMGFVTRGGGVSVHRTDCTNAASLQQQSERIIEVHWAPSPSSVFLVAIQVEALDR
CCCHHHEEEEECCCCCEEEECCCCCHHHHHHHCCCEEEEEECCCCCCEEEEEEEEHHHHH
HRLLSDVTRVLADEKVNILSASVTTSGDRVAISRFTFEMGDPKHLGHLLNVVRNVEGVYD
HHHHHHHHHHHHCCCHHEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
VYRVTSAA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]