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The map label for this gene is mprB [H]

Identifier: 41407015

GI number: 41407015

Start: 949137

End: 950672

Strand: Direct

Name: mprB [H]

Synonym: MAP0917

Alternate gene names: 41407015

Gene position: 949137-950672 (Clockwise)

Preceding gene: 41407014

Following gene: 41407016

Centisome position: 19.65

GC content: 69.86

Gene sequence:

>1536_bases
TTGCGCGCGCCCCTGCGCGCCACCCCCTCGCTGTCGCTGCGATGGCGGGTGATGCTGCTGGCCATGTCGATGGTGGCCAT
GGTCGTGGTGCTGATGGCGTTCGCCGTCTATGCCGTGATTTCGGCCGCTCTCTACAGCGACATCGACAACCAACTGCAGA
GCCGGGCGCAACTGCTGATCGCCAGCGGCTCGTTGGCCGCCGACCCCGGCAAGGCGATCGAGGGCACCGCCTATTCGGAC
GTCAACGCGATGCTGGTGAACCCCGGCCACGCCATCTACACCGCCCAGCAGCCGGGTCAGACGCTGCCGGTGGGGTCGCC
GGAAAAGGCGGTCATCCACGGCGAACTGTTCATGTCGCGGCGCACCGCGGGCGATCAGCGCATCCTGGCCGTGCACCTGC
AGAACGGCACGTCGTTGCTGATCTCCAAGAGCCTCAAGCCGACCGAGGCGGTGATGAACAAACTGCGGTGGGTGCTGCTG
ATCGTCGGAGGTGTCGGCGTGGCCGTCGCGGCGGTGGCGGGCGGCATGGTCACCCGGGCCGGGTTGCGCCCGGTGGCCCG
CCTGACCGAAGCGGCCGAGCGGGTGGCGCGCACCGACGACCTGCGGCCCATCCCGGTGTTCGGCAGCGACGAATTGGCCA
GGCTCACCGAGTCGTTCAACCTGATGCTGCGGGCGCTGGCCGAGTCCCGGGAGCGACAGGCCCGGCTGGTCACCGACGCC
GGACACGAATTGCGCACCCCGCTGACGTCGCTGCGCACCAACGTCGAGCTGCTGATGGCCTCGATGGAGCCGGGCGCCCC
GCGGCTGCCCGAGCAGGAGATGGTCGAGCTGCGCGCCGATGTGCTCGCCCAGATCGAGGAATTGTCAACGCTGGTAGGCG
ATTTGGTGGACCTCACCCGCGACGACGCCGGGCAGGTGGTGCACGAGCCGGTCGACATGTCCGATGTGATCGATCGCAGC
CTGGAGCGAGTCAGGCGGCGGCGCAACGACATTCACTTCGACGTCGATGTGACGCCGTGGCAGATGTACGGCGATGCCGC
CGGGTTGTCGCGTGCGGTGCTCAACCTGTTGGACAACGCGGCCAAGTGGAGCCCGCCCGGCGGGCACGTCGGCGTCACGA
TGCGCCAGCTCGACCCGTCGCACGTCGAGCTGGTGGTCTCTGACCACGGGCCCGGCATTCCGCCGCAGGAGCGCCGGCTG
GTGTTCGAGCGGTTCTACCGCTCGACGTCGGCGCGGGCCATGCCCGGCTCCGGGCTGGGGCTGGCCATCGTCAAGAAGGT
CGTGCTCAACCACGGCGGCATGCTGCGCGTCGAGGACACGGTGCCGGGCGGCCAGCCGCCGGGCACCTCCTTCTATGTGC
TGCTGCCGGGGCGGTCGCTGCCGCCGGCCGGCCACTCGACGCCCGCCGGCGAGTCGGAAACCGACCAGGCGGAGGCCGCC
ACCGACCCCGCCGTACCGGTGGCCGGGGACACGGCGAACTCTCGGGAATCGGCGAACGTTATCTCAGTGGACTCTCAGTC
CGCGCGGGCAAGGTAG

Upstream 100 bases:

>100_bases
ATCCACACTGTGCGCGGGGTGGGTTACGTGCTTCGGGAGACGCCGCCGTGACGAGCCGCCCGCCGCGATGATCCGGTTGT
ACCGGCCCCAGCGCCCCCCG

Downstream 100 bases:

>100_bases
GTCTGCGGCTACTGTTAAACCCAGCCGAGCCGAGCCCACCGCGAGCCGAAACGCCGAGATAGAGGAAGAGCGACTTAGCG
ACATGACGAATGACCCGAGG

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MRAPLRATPSLSLRWRVMLLAMSMVAMVVVLMAFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSD
VNAMLVNPGHAIYTAQQPGQTLPVGSPEKAVIHGELFMSRRTAGDQRILAVHLQNGTSLLISKSLKPTEAVMNKLRWVLL
IVGGVGVAVAAVAGGMVTRAGLRPVARLTEAAERVARTDDLRPIPVFGSDELARLTESFNLMLRALAESRERQARLVTDA
GHELRTPLTSLRTNVELLMASMEPGAPRLPEQEMVELRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPVDMSDVIDRS
LERVRRRRNDIHFDVDVTPWQMYGDAAGLSRAVLNLLDNAAKWSPPGGHVGVTMRQLDPSHVELVVSDHGPGIPPQERRL
VFERFYRSTSARAMPGSGLGLAIVKKVVLNHGGMLRVEDTVPGGQPPGTSFYVLLPGRSLPPAGHSTPAGESETDQAEAA
TDPAVPVAGDTANSRESANVISVDSQSARAR

Sequences:

>Translated_511_residues
MRAPLRATPSLSLRWRVMLLAMSMVAMVVVLMAFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSD
VNAMLVNPGHAIYTAQQPGQTLPVGSPEKAVIHGELFMSRRTAGDQRILAVHLQNGTSLLISKSLKPTEAVMNKLRWVLL
IVGGVGVAVAAVAGGMVTRAGLRPVARLTEAAERVARTDDLRPIPVFGSDELARLTESFNLMLRALAESRERQARLVTDA
GHELRTPLTSLRTNVELLMASMEPGAPRLPEQEMVELRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPVDMSDVIDRS
LERVRRRRNDIHFDVDVTPWQMYGDAAGLSRAVLNLLDNAAKWSPPGGHVGVTMRQLDPSHVELVVSDHGPGIPPQERRL
VFERFYRSTSARAMPGSGLGLAIVKKVVLNHGGMLRVEDTVPGGQPPGTSFYVLLPGRSLPPAGHSTPAGESETDQAEAA
TDPAVPVAGDTANSRESANVISVDSQSARAR
>Mature_511_residues
MRAPLRATPSLSLRWRVMLLAMSMVAMVVVLMAFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSD
VNAMLVNPGHAIYTAQQPGQTLPVGSPEKAVIHGELFMSRRTAGDQRILAVHLQNGTSLLISKSLKPTEAVMNKLRWVLL
IVGGVGVAVAAVAGGMVTRAGLRPVARLTEAAERVARTDDLRPIPVFGSDELARLTESFNLMLRALAESRERQARLVTDA
GHELRTPLTSLRTNVELLMASMEPGAPRLPEQEMVELRADVLAQIEELSTLVGDLVDLTRDDAGQVVHEPVDMSDVIDRS
LERVRRRRNDIHFDVDVTPWQMYGDAAGLSRAVLNLLDNAAKWSPPGGHVGVTMRQLDPSHVELVVSDHGPGIPPQERRL
VFERFYRSTSARAMPGSGLGLAIVKKVVLNHGGMLRVEDTVPGGQPPGTSFYVLLPGRSLPPAGHSTPAGESETDQAEAA
TDPAVPVAGDTANSRESANVISVDSQSARAR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=31.7343173431734, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=30.0724637681159, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786783, Length=329, Percent_Identity=27.355623100304, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789808, Length=285, Percent_Identity=28.7719298245614, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=33.4782608695652, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=30.952380952381, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=26.1648745519713, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1786912, Length=271, Percent_Identity=28.4132841328413, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789403, Length=469, Percent_Identity=24.3070362473348, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=26.6917293233083, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=25.6410256410256, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=26.1016949152542, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790551, Length=291, Percent_Identity=26.4604810996564, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788549, Length=248, Percent_Identity=25.4032258064516, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=351, Percent_Identity=26.7806267806268, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=24.8945147679325, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=293, Percent_Identity=28.3276450511945, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=26.1061946902655, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789149, Length=521, Percent_Identity=20.5374280230326, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54829; Mature: 54829

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPLRATPSLSLRWRVMLLAMSMVAMVVVLMAFAVYAVISAALYSDIDNQLQSRAQLLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
ASGSLAADPGKAIEGTAYSDVNAMLVNPGHAIYTAQQPGQTLPVGSPEKAVIHGELFMSR
ECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHH
RTAGDQRILAVHLQNGTSLLISKSLKPTEAVMNKLRWVLLIVGGVGVAVAAVAGGMVTRA
CCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRPVARLTEAAERVARTDDLRPIPVFGSDELARLTESFNLMLRALAESRERQARLVTDA
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GHELRTPLTSLRTNVELLMASMEPGAPRLPEQEMVELRADVLAQIEELSTLVGDLVDLTR
CHHHHCCHHHHHHCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDAGQVVHEPVDMSDVIDRSLERVRRRRNDIHFDVDVTPWQMYGDAAGLSRAVLNLLDNA
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHH
AKWSPPGGHVGVTMRQLDPSHVELVVSDHGPGIPPQERRLVFERFYRSTSARAMPGSGLG
HCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
LAIVKKVVLNHGGMLRVEDTVPGGQPPGTSFYVLLPGRSLPPAGHSTPAGESETDQAEAA
HHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHC
TDPAVPVAGDTANSRESANVISVDSQSARAR
CCCCCCCCCCCCCCCCCCCEEEECCHHCCCC
>Mature Secondary Structure
MRAPLRATPSLSLRWRVMLLAMSMVAMVVVLMAFAVYAVISAALYSDIDNQLQSRAQLLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
ASGSLAADPGKAIEGTAYSDVNAMLVNPGHAIYTAQQPGQTLPVGSPEKAVIHGELFMSR
ECCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHH
RTAGDQRILAVHLQNGTSLLISKSLKPTEAVMNKLRWVLLIVGGVGVAVAAVAGGMVTRA
CCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLRPVARLTEAAERVARTDDLRPIPVFGSDELARLTESFNLMLRALAESRERQARLVTDA
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GHELRTPLTSLRTNVELLMASMEPGAPRLPEQEMVELRADVLAQIEELSTLVGDLVDLTR
CHHHHCCHHHHHHCHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DDAGQVVHEPVDMSDVIDRSLERVRRRRNDIHFDVDVTPWQMYGDAAGLSRAVLNLLDNA
CCCCHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHH
AKWSPPGGHVGVTMRQLDPSHVELVVSDHGPGIPPQERRLVFERFYRSTSARAMPGSGLG
HCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCH
LAIVKKVVLNHGGMLRVEDTVPGGQPPGTSFYVLLPGRSLPPAGHSTPAGESETDQAEAA
HHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHC
TDPAVPVAGDTANSRESANVISVDSQSARAR
CCCCCCCCCCCCCCCCCCCEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA