Click here to switch to the map view.

The map label for this gene is htrA [H]

Identifier: 41407016

GI number: 41407016

Start: 950755

End: 952221

Strand: Direct

Name: htrA [H]

Synonym: MAP0918

Alternate gene names: 41407016

Gene position: 950755-952221 (Clockwise)

Preceding gene: 41407015

Following gene: 41407017

Centisome position: 19.69

GC content: 71.92

Gene sequence:

>1467_bases
ATGACGAATGACCCGAGGTATTCGCCACCGCCGCAGCAGCAGCCGGGATACCCGCCCGCGCCGAATCAGACTGCGCCCGT
CCCGAGCCACGCGGGCTCCTCAGGCTATGCCCAGGGGCAGCAGCCCTACCAGCAGCAATTCGACTGGCGCTATCGGTCGC
AGCCCTCGCAAACCACCCAGTTCCGCTCGCCCTACGAGCCCTTCGGCAACGCCGGGCCGGGACGCGTCCCCGGCGGCACC
GGCACCGGTCCGCTGCCCGGCATGCATCCCGGGATGCCCGCCCCGCCGGAACCTCAAAAGCGTTCTCGCGCAGGTCTATT
GACGGTGGGAGCGGTGGCCATCGCGGTGGTGTCGGCCGGCATCGGCGGTGCCGCGGCAACGGCCGTCGAAATGGGCACCC
ACGCAACGGGCAGCGGCGGCGGGCGCATCGCCGGGGCGGCGCCCAGCGTCCCGGCGGCGAACATGCCGCCGGGCAGTGTC
GAGCAGGTGGCGGCCAAGGTGGTGCCCAGCGTGGTGATGCTGGAGACCGATCTGGGCCGTCAGTCCGAGGAGGGCTCCGG
CATCATCCTGTCGACCGACGGGCTGATCCTGACCAACAACCACGTCGTCGCGGCCGCGGCGGGACCGCCCAAGGGTCCCG
CGGCGCCCCCGGTGGTCCCGCTGCCGCCCGGCGGCCCGGGCGGTGGTCCCGGCGCCGGCACCCCGAAGACGACGGTCACC
TTCTCCGACGGCCGCACCGCGCCGTTCACGGTGGTCGGTGCCGACCCCACCAGCGATATCGCCGTCATCCGGGTGCAGGG
CATGTCCGGGCTCACCCCCATCTCGCTGGGGTCGTCGTCGGACCTGCGGGTCGGTCAGCCGGTGGTGGCGATCGGGTCGC
CGCTGGGTCTGTCCGGCACGGTGACCACCGGGATCGTCAGCGCCCTGAACCGGCCGGTGTCCACCACCGGTGAGTCCGGC
AACCAGAACACCGTGCTGGACGCTATCCAGACCGACGCCGCGATCAACCCCGGCAACTCCGGGGGAGCGTTGGTCAACAT
GAACGGCCAACTGGTGGGCGTGAACTCGGCCATCGCCACGCTGGGCGCCGACTCGCCGGACGCGCAGAGCGGCTCGATCG
GGCTGGGCTTCGCGATCCCGGTCGACCAGGCCAAGCGGATCGCCGACGAGCTGATCGCCACCGGCAAGGCGTCACATGCC
TCGCTGGGCGTGCAGGTGACCAACGACAAGGGCACCCCGGGCGCCAAGGTCGTCGACGTGGTGTCGGGCGGTGCGGCCGC
CAGCGCCGGCCTGCCCAAGAACGTGGTCGTCACCAAGGTCGACGACCGCCCGATCAACAGCGCCGACGCGTTGGTCGCCG
CCGTGCGGTCCAAGGCGCCGGGCGACAAGATCACGTTGACGTTCTCCGATCCCGCCGGCGGCGGCAGCCGGACTTTGCCG
GTCACCCTGGGAAAGGCGGACCAGTAG

Upstream 100 bases:

>100_bases
TCCGCGCGGGCAAGGTAGGTCTGCGGCTACTGTTAAACCCAGCCGAGCCGAGCCCACCGCGAGCCGAAACGCCGAGATAG
AGGAAGAGCGACTTAGCGAC

Downstream 100 bases:

>100_bases
TGAGAGTGGACGAACCCTCGGCGGCGGGATTGTCGGAGCTCGGATATACGGTTGCACCCATGGAAACGGGTGCGGAGTTG
GTAGTTGGCCGGGCACTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTNDPRYSPPPQQQPGYPPAPNQTAPVPSHAGSSGYAQGQQPYQQQFDWRYRSQPSQTTQFRSPYEPFGNAGPGRVPGGT
GTGPLPGMHPGMPAPPEPQKRSRAGLLTVGAVAIAVVSAGIGGAAATAVEMGTHATGSGGGRIAGAAPSVPAANMPPGSV
EQVAAKVVPSVVMLETDLGRQSEEGSGIILSTDGLILTNNHVVAAAAGPPKGPAAPPVVPLPPGGPGGGPGAGTPKTTVT
FSDGRTAPFTVVGADPTSDIAVIRVQGMSGLTPISLGSSSDLRVGQPVVAIGSPLGLSGTVTTGIVSALNRPVSTTGESG
NQNTVLDAIQTDAAINPGNSGGALVNMNGQLVGVNSAIATLGADSPDAQSGSIGLGFAIPVDQAKRIADELIATGKASHA
SLGVQVTNDKGTPGAKVVDVVSGGAAASAGLPKNVVVTKVDDRPINSADALVAAVRSKAPGDKITLTFSDPAGGGSRTLP
VTLGKADQ

Sequences:

>Translated_488_residues
MTNDPRYSPPPQQQPGYPPAPNQTAPVPSHAGSSGYAQGQQPYQQQFDWRYRSQPSQTTQFRSPYEPFGNAGPGRVPGGT
GTGPLPGMHPGMPAPPEPQKRSRAGLLTVGAVAIAVVSAGIGGAAATAVEMGTHATGSGGGRIAGAAPSVPAANMPPGSV
EQVAAKVVPSVVMLETDLGRQSEEGSGIILSTDGLILTNNHVVAAAAGPPKGPAAPPVVPLPPGGPGGGPGAGTPKTTVT
FSDGRTAPFTVVGADPTSDIAVIRVQGMSGLTPISLGSSSDLRVGQPVVAIGSPLGLSGTVTTGIVSALNRPVSTTGESG
NQNTVLDAIQTDAAINPGNSGGALVNMNGQLVGVNSAIATLGADSPDAQSGSIGLGFAIPVDQAKRIADELIATGKASHA
SLGVQVTNDKGTPGAKVVDVVSGGAAASAGLPKNVVVTKVDDRPINSADALVAAVRSKAPGDKITLTFSDPAGGGSRTLP
VTLGKADQ
>Mature_487_residues
TNDPRYSPPPQQQPGYPPAPNQTAPVPSHAGSSGYAQGQQPYQQQFDWRYRSQPSQTTQFRSPYEPFGNAGPGRVPGGTG
TGPLPGMHPGMPAPPEPQKRSRAGLLTVGAVAIAVVSAGIGGAAATAVEMGTHATGSGGGRIAGAAPSVPAANMPPGSVE
QVAAKVVPSVVMLETDLGRQSEEGSGIILSTDGLILTNNHVVAAAAGPPKGPAAPPVVPLPPGGPGGGPGAGTPKTTVTF
SDGRTAPFTVVGADPTSDIAVIRVQGMSGLTPISLGSSSDLRVGQPVVAIGSPLGLSGTVTTGIVSALNRPVSTTGESGN
QNTVLDAIQTDAAINPGNSGGALVNMNGQLVGVNSAIATLGADSPDAQSGSIGLGFAIPVDQAKRIADELIATGKASHAS
LGVQVTNDKGTPGAKVVDVVSGGAAASAGLPKNVVVTKVDDRPINSADALVAAVRSKAPGDKITLTFSDPAGGGSRTLPV
TLGKADQ

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=326, Percent_Identity=31.9018404907975, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4506141, Length=330, Percent_Identity=31.2121212121212, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI24308541, Length=326, Percent_Identity=32.2085889570552, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI7019477, Length=333, Percent_Identity=29.7297297297297, Blast_Score=113, Evalue=5e-25,
Organism=Escherichia coli, GI1786356, Length=294, Percent_Identity=39.4557823129252, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789629, Length=293, Percent_Identity=36.518771331058, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789630, Length=337, Percent_Identity=31.1572700296736, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646839, Length=363, Percent_Identity=31.9559228650138, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48027; Mature: 47896

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDPRYSPPPQQQPGYPPAPNQTAPVPSHAGSSGYAQGQQPYQQQFDWRYRSQPSQTTQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCHHH
FRSPYEPFGNAGPGRVPGGTGTGPLPGMHPGMPAPPEPQKRSRAGLLTVGAVAIAVVSAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHHHHHHHHHHCC
IGGAAATAVEMGTHATGSGGGRIAGAAPSVPAANMPPGSVEQVAAKVVPSVVMLETDLGR
CCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCC
QSEEGSGIILSTDGLILTNNHVVAAAAGPPKGPAAPPVVPLPPGGPGGGPGAGTPKTTVT
CCCCCCEEEEECCCEEEECCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEE
FSDGRTAPFTVVGADPTSDIAVIRVQGMSGLTPISLGSSSDLRVGQPVVAIGSPLGLSGT
ECCCCCCCEEEECCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCH
VTTGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALVNMNGQLVGVNSAIAT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCEEEECCHHHHH
LGADSPDAQSGSIGLGFAIPVDQAKRIADELIATGKASHASLGVQVTNDKGTPGAKVVDV
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEE
VSGGAAASAGLPKNVVVTKVDDRPINSADALVAAVRSKAPGDKITLTFSDPAGGGSRTLP
ECCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEE
VTLGKADQ
EECCCCCC
>Mature Secondary Structure 
TNDPRYSPPPQQQPGYPPAPNQTAPVPSHAGSSGYAQGQQPYQQQFDWRYRSQPSQTTQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHCCCCCCHHH
FRSPYEPFGNAGPGRVPGGTGTGPLPGMHPGMPAPPEPQKRSRAGLLTVGAVAIAVVSAG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEHHHHHHHHHHHCC
IGGAAATAVEMGTHATGSGGGRIAGAAPSVPAANMPPGSVEQVAAKVVPSVVMLETDLGR
CCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCC
QSEEGSGIILSTDGLILTNNHVVAAAAGPPKGPAAPPVVPLPPGGPGGGPGAGTPKTTVT
CCCCCCEEEEECCCEEEECCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEEE
FSDGRTAPFTVVGADPTSDIAVIRVQGMSGLTPISLGSSSDLRVGQPVVAIGSPLGLSGT
ECCCCCCCEEEECCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEECCCCCCCCH
VTTGIVSALNRPVSTTGESGNQNTVLDAIQTDAAINPGNSGGALVNMNGQLVGVNSAIAT
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCEEEECCHHHHH
LGADSPDAQSGSIGLGFAIPVDQAKRIADELIATGKASHASLGVQVTNDKGTPGAKVVDV
CCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEE
VSGGAAASAGLPKNVVVTKVDDRPINSADALVAAVRSKAPGDKITLTFSDPAGGGSRTLP
ECCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEE
VTLGKADQ
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]