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The map label for this gene is mprA [H]

Identifier: 41407014

GI number: 41407014

Start: 948401

End: 949087

Strand: Direct

Name: mprA [H]

Synonym: MAP0916

Alternate gene names: 41407014

Gene position: 948401-949087 (Clockwise)

Preceding gene: 41407013

Following gene: 41407015

Centisome position: 19.64

GC content: 68.27

Gene sequence:

>687_bases
GTGCGAATACTGGTCGTCGACGACGATCGCGCGGTGCGCGAGTCGTTACGCAGGTCGTTGTCCTTCAACGGCTACTCCGT
CGAGTTGGCCCATGACGGGGTCGAGGCTCTCGACATGATCGCGAGCGATCGCCCCGACGCGCTCGTCCTGGATGTGATGA
TGCCGCGACTGGATGGCCTCGAGGTGTGCCGTCAGCTGCGCAGCACCGGTGACGACCTGCCCATCCTGGTGCTGACGGCC
CGCGATTCGGTCTCCGAGCGGGTGGCCGGGCTGGACGCGGGCGCCGACGACTACCTGCCCAAGCCGTTCGCCCTGGAAGA
ACTGCTGGCCCGGATGCGGGCGCTGCTGCGCCGCACCAAGCCCGAGGACGACGCCGAATCCGTGGCGATGACGTTCTCCG
ATCTGACGCTGGACCCGGTGACCCGGGAGGTCACCCGCGGGCAGCGCCGGATCAGCCTGACGCGCACCGAGTTCGCACTG
CTGGAAATGCTGATCGCCAACCCGCGCCGGGTGCTCACCCGCAGCCGCATCCTCGAGGAGGTCTGGGGCTTCGACTTCCC
CACCTCGGGCAATGCGCTGGAGGTGTACGTCGGCTACCTGCGCCGCAAAACCGAAGCCGACGGCGAGCCGCGGTTGATCC
ACACTGTGCGCGGGGTGGGTTACGTGCTTCGGGAGACGCCGCCGTGA

Upstream 100 bases:

>100_bases
CCCGCTGCGCCCGGCTTTCGCCGCGCTGGCGACCGCCGCTGACCTTGATGGCGGCGCGCCTCTCAGGTCAGTCTCAGGCG
GTGGGACGAAACTAGGGGCC

Downstream 100 bases:

>100_bases
CGAGCCGCCCGCCGCGATGATCCGGTTGTACCGGCCCCAGCGCCCCCCGTTGCGCGCGCCCCTGCGCGCCACCCCCTCGC
TGTCGCTGCGATGGCGGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDDAESVAMTFSDLTLDPVTREVTRGQRRISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP

Sequences:

>Translated_228_residues
MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDDAESVAMTFSDLTLDPVTREVTRGQRRISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
>Mature_228_residues
MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTA
RDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDDAESVAMTFSDLTLDPVTREVTRGQRRISLTRTEFAL
LEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=44.1048034934498, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=41.7777777777778, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.9140271493213, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=40, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=36.9369369369369, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=38.5650224215247, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=35.8744394618834, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=35.5555555555556, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=39.7379912663755, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.0316742081448, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=28.6343612334802, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.004329004329, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=37.962962962963, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=161, Percent_Identity=33.5403726708075, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=40, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=135, Percent_Identity=35.5555555555556, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693157, Length=125, Percent_Identity=32.8, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788191, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25682; Mature: 25682

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHHCCCCHH
EVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTK
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PEDDAESVAMTFSDLTLDPVTREVTRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEE
CCCCHHHHHHHHHCCCCCHHHHHHHCCHHHEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGL
CEEEEECCCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHHCCCCHH
EVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTK
HHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
PEDDAESVAMTFSDLTLDPVTREVTRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEE
CCCCHHHHHHHHHCCCCCHHHHHHHCCHHHEEHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA